Results 131 to 140 of about 159,275 (311)

Antimicrobial Stewardship in Pediatrics

Antibiotics
Since the discovery of antibiotics in the early 20th century, significant changes have occurred in their usage principles [...]
Radoslaw Jaworski, Katarzyna Dzierzanowska-Fangrat   +1 more
doaj   +1 more source

Heart failure in patients with a systemic right ventricle: A multicentre study with long‐term follow‐up

European Journal of Heart Failure, EarlyView.
Risk of heart failure hospitalization in patients with a systemic right ventricle. AF, atrial fibrillation; AtrSO, atrial switch operation; ccTGA, congenitally corrected transposition of the great arteries; D‐TGA, dextro‐transposition of the great arteries; ECG, electrocardiogram; HF, heart failure; HR, hazard ratio; NYHA, New York Heart Association ...
Mohammad Mostafa Ansari Ramandi, Werner Budts, Jolien W. Roos‐Hesselink, Willem A. Helbing, Anastasia D. Egorova, Berto J. Bouma, Anthonie Duijnhouwer, Roland van Kimmenade, Gertjan T. Sieswerda, Thelma C. Konings, Lodewijk J. Wagenaar, Joey F.A. Ubachs, Rolf M.F. Berger, Elke S. Hoendermis, Adriaan A. Voors, Joost P. van Melle   +15 more
wiley   +1 more source

Coordinated expression of BMP10/ALK1/endoglin—proteins that drive embryonic cardiac and vascular morphogenesis—in patients with heart failure: The EMPEROR Program

European Journal of Heart Failure, EarlyView.
Aims Bone morphogenetic protein 10 (BMP10), activin receptor‐like kinase 1 (ALK1) and endoglin form a single transforming growth factor‐β family signalling complex that is the principal driver of cardiac and vascular morphogenesis and maturation during hypoxic embryonic development. These proteins are down‐regulated with the onset of normoxia at birth,
Milton Packer, Javed Butler, João Pedro Ferreira, Tariq Jamal Siddiqi, James L. Januzzi Jr, Naveed Sattar, Sandra González Maldonado, Marina Panova‐Noeva, Jürgen H. Prochaska, Mikhail Sumin, Serge Masson, Stuart J. Pocock, Gerasimos Filippatos, Stefan D. Anker, Faiez Zannad   +14 more
wiley   +1 more source

The triple challenges associated with age-related comorbidities in Down syndrome [PDF]

, 2014
Background Major increases in the survival of people with Down syndrome during the last two generations have resulted in extended periods of adulthood requiring specialist care, which in turn necessitates greater understanding of the nature, timing and ...
Bittles, A.H., Dye, D.E., Glasson, E.J.
core   +1 more source

Severity of effect considerations regarding the use of mutation as a toxicological endpoint for risk assessment: A report from the 8th International Workshop on Genotoxicity Testing (IWGT)

Environmental and Molecular Mutagenesis, EarlyView.
Abstract Exposure levels without appreciable human health risk may be determined by dividing a point of departure on a dose–response curve (e.g., benchmark dose) by a composite adjustment factor (AF). An “effect severity” AF (ESAF) is employed in some regulatory contexts.
Barbara L. Parsons, Marc A. Beal, Kerry L. Dearfield, George R. Douglas, Min Gi, B. Bhaskar Gollapudi, Robert H. Heflich, Katsuyoshi Horibata, Michelle Kenyon, Alexandra S. Long, David P. Lovell, Anthony M. Lynch, Meagan B. Myers, Stefan Pfuhler, Alisa Vespa, Andreas Zeller, George E. Johnson, Paul A. White   +17 more
wiley   +1 more source

Critical Evaluation of Methods for the Identification of Aneugens

Environmental and Molecular Mutagenesis, EarlyView.
ABSTRACT The genotoxic potential of chemicals must be evaluated in regulatory safety assessment settings, including but not limited to, the development of new pharmaceuticals, industrial chemicals, food and cosmetic ingredients, and agrochemicals. Initial assessment of the chromosome‐damaging potential of chemicals is often conducted in mammalian cells
Xiaowen Sun, Stephen D. Dertinger, Azeddine Elhajouji, Daniel J. Roberts, Jan van Benthem, Maik Schuler, Shambhu Roy, Alexandra Taraboletti, Connie L. Chen   +8 more
wiley   +1 more source

A univentricular heart : tricuspid atresia [PDF]

, 2013
A two-year-three-month-old boy was diagnosed with tricuspid atresia. This condition requires three surgical interventions, of which he has already had two. He has now presented to hospital with shortness of breath.
Mifsud, Simon, Schembri, Emma
core  

Inherited metabolic epilepsies–established diseases, new approaches

Epilepsia Open, EarlyView.
Abstract Inherited metabolic epilepsies (IMEs) represent the inherited metabolic disorders (IMDs) in which epilepsy is a prevailing component, often determining other neurodevelopmental outcomes associated with the disorder. The different metabolic pathways affected by individual IMEs are the basis of their rarity and heterogeneity.
Itay Tokatly Latzer, Phillip L. Pearl
wiley   +1 more source

Prognostic Value of Speckle Tracking Echocardiography-Derived Strain in Unmasking Risk for Arrhythmias in Children with Myocarditis

Biomedicines
Background/Objectives: Risk assessment in pediatric myocarditis is challenging, particularly when left ventricular ejection fraction (LVEF) is preserved. This study aimed to evaluate LV myocardial deformation using speckle-tracking echocardiography (STE)-
Nele Rolfs, Cynthia Huber, Bernd Opgen-Rhein, Isabell Altmann, Felix Anderheiden, Tobias Hecht, Marcus Fischer, Gesa Wiegand, Katja Reineker, Inga Voges, Daniela Kiski, Wiebke Frede, Martin Boehne, Malika Khedim, Daniel Messroghli, Karin Klingel, Eicke Schwarzkopf, Thomas Pickardt, Stephan Schubert, Fatima I. Lunze, Franziska Seidel   +20 more
doaj   +1 more source

Genetic epilepsies with myoclonic seizures: Mechanisms and syndromes

Epilepsia Open, EarlyView.
Abstract Genetic epilepsy with myoclonic seizures encompasses a heterogeneous spectrum of conditions, ranging from benign and self‐limiting forms to severe, progressive disorders. While their causes are diverse, a significant proportion stems from genetic abnormalities.
Antonietta Coppola, Marica Rubino, Antonella Riva, Pasquale Striano   +3 more
wiley   +1 more source