Results 11 to 20 of about 4,409,619 (351)

MEF2C regulates outflow tract alignment and transcriptional control of Tdgf1 [PDF]

, 2016
Congenital heart defects are the most common birth defects in humans, and those that affect the proper alignment of the outflow tracts and septation of the ventricles are a highly significant cause of morbidity and mortality in infants.
Barnes, Ralston M., Black, Brian L., Harris, Ian S., Jaehnig, E., McCulley, David J., Norris, Russell A., Rojas González, Anabel, Sauls, Kimberly, Schachterle, William, Sinha, Tanvi   +9 more
core   +1 more source

Global birth prevalence of congenital heart defects 1970–2017: updated systematic review and meta-analysis of 260 studies

International Journal of Epidemiology, 2019
Background Globally, access to healthcare and diagnostic technologies are known to substantially impact the reported birth prevalence of congenital heart disease (CHD).
Yingjuan Liu, Sen Chen, L. Zühlke, G. Black, M. Choy, Ningxiu Li, B. Keavney   +6 more
semanticscholar   +1 more source

Multi-chamber cardioids unravel human heart development and cardiac defects

bioRxiv, 2022
The number one cause of human fetal death are defects in heart development. Because the human embryonic heart is inaccessible, and the impacts of mutations, drugs, and environmental factors on the specialized functions of different heart compartments are
Clara Schmidt, Alison Deyett, Tobias Ilmer, Aranxa Torres Caballero, Simon Haendeler, L. Pimpale, Michael A. Netzer, Lavinia Ceci Ginistrelli, Martina Cirigliano, Estela Juncosa Mancheno, Daniel Reumann, Katherina Tavernini, Steffen Hering, Pablo Hofbauer, Sasha Mendjan   +14 more
semanticscholar   +1 more source

Oxygen Availability in Respiratory Muscles During Exercise in Children Following Fontan Operation

Frontiers in Pediatrics, 2019
Introduction: As survival of previously considered as lethal congenital heart disease forms is the case in our days, issues regarding quality of life including sport and daily activities emerge.
Fabian Stöcker, Rhoia Neidenbach, Celina Fritz, Renate M. Oberhoffer, Peter Ewert, Alfred Hager, Nicole Nagdyman   +6 more
doaj   +1 more source

Cardiac Muscle Training—A New Way of Recognizing and Supporting Recovery for LVAD Patients in the Pediatric Population

Life, 2022
Patients with refractory heart failure due to chronic progressive cardiac myopathy (CM) may require mechanical circulatory support as a bridge to transplantation. A few patients can be weaned from support devices if recovery can be achieved.
Anca Racolta, Jae-Hyun Johannes Ahn, Marinos Kantzis, Hendrik Milting, Volker Lauenroth, Hermann Körperich, Eugen Sandica, Stephan Schubert, Kai Thorsten Laser   +8 more
doaj   +1 more source

Substantial radiation reduction in pediatric and adult congenital heart disease interventions with a novel X-ray imaging technology

International Journal of Cardiology: Heart & Vasculature, 2015
Background: Pediatric catheterization exposes patients to varying radiation doses. Concerns over the effects of X-ray radiation dose on the patient population have increased in recent years.
Nikolaus A. Haas, Christoph M. Happel, Maria Mauti, Cherif Sahyoun, Lea Z. Tebart, Deniz Kececioglu, Kai Thorsten Laser   +6 more
doaj   +1 more source

Exogenous WNT5A and WNT11 proteins rescue CITED2 dysfunction in mouse embryonic stem cells and zebrafish morphants [PDF]

, 2019
Mutations and inadequate methylation profiles of CITED2 are associated with human congenital heart disease (CHD). In mouse, Cited2 is necessary for embryogenesis, particularly for heart development, and its depletion in embryonic stem cells (ESC) impairs
AC Fahed, AC Michell, B Bamforth, B Li, B Xu, BG Bruneau, C-M Chen, CA Eisenberg, D Fraidenraich, D Sabour, ED Cohen, EY Chen, H Mori, H Thomas, I Pacheco-Leyva, J Bakkers, JA Bisson, JA Gaspar, JP Pinto, JPM Barbera, K Meganathan, KR Kranc, M Sahara, M Xu, MV Kuleshov, P Andre, P Choudhry, P Hu, Q Li, S Bhattacharya, S Liu, S Mazzotta, S Sperling, S Ueno, S Zaidi, S-W Cha, SD Bamforth, ST MacDonald, ST MacDonald, T Tan, V Kouskoff, V Wagh, VK Khodiyar, WJ Weninger, Y Liu, Z Yin   +45 more
core   +1 more source

Heart Defects in Connexin43-Deficient Mice [PDF]

Circulation Research, 1998
Abstract —Cardiac malformation in connexin43 (CX43)-disrupted mice is restricted to the junction between right ventricle and outflow tract, even though CX43 is also expressed abundantly elsewhere. We analyzed cardiac morphogenesis in immunohistochemically and hybridohistochemically stained and three-dimensionally reconstructed ...
Ya, J., Erdtsieck-Ernste, E. B., de Boer, P. A., van Kempen, M. J., Jongsma, H., Gros, D., Moorman, A. F., Lamers, W. H.   +7 more
openaire   +4 more sources

A Biobank for Long-term and Sustainable Research in the Field of Congenital Heart Disease in Germany

Genomics, Proteomics & Bioinformatics, 2016
Congenital heart disease (CHD) is the most frequent birth defect (0.8%–1% of all live births). Due to the advance in prenatal and postnatal early diagnosis and treatment, more than 90% of these patients survive into adulthood today. However, several mid-
Thomas Pickardt, Eva Niggemeyer, Ulrike M.M. Bauer, Hashim Abdul-Khaliq   +3 more
doaj   +1 more source

Gene-based genome-wide association studies and meta-analyses of conotruncal heart defects. [PDF]

, 2019
Conotruncal heart defects (CTDs) are among the most common and severe groups of congenital heart defects. Despite evidence of an inherited genetic contribution to CTDs, little is known about the specific genes that contribute to the development of CTDs ...
Agopian, AJ, Goldmuntz, Elizabeth, Hakonarson, Hakon, Mitchell, Laura E, Morrow, Bernice E, Pediatric Cardiac Genomics Consortium, Sewda, Anshuman, Taylor, Deanne   +7 more
core   +2 more sources