Results 101 to 110 of about 14,472,131 (409)

Monomorphic Ventricular Arrhythmias in Athletes. [PDF]

, 2019
Ventricular arrhythmias are challenging to manage in athletes with concern for an elevated risk of sudden cardiac death (SCD) during sports competition. Monomorphic ventricular arrhythmias (MMVA), while often benign in athletes with a structurally normal
Aboulhosn, Jamil A, Boyle, Noel G, Bradfield, Jason S, Dave, Ravi H, Horwich, Tamara B, Hsu, Jeffrey J, Nsair, Ali, Shannon, Kevin M, Shivkumar, Kalyanam   +8 more
core   +2 more sources

Structural biology of ferritin nanocages

FEBS Letters, EarlyView.
Ferritin is a conserved iron‐storage protein that sequesters iron as a ferric mineral core within a nanocage, protecting cells from oxidative damage and maintaining iron homeostasis. This review discusses ferritin biology, structure, and function, and highlights recent cryo‐EM studies revealing mechanisms of ferritinophagy, cellular iron uptake, and ...
Eloise Mastrangelo, Flavio Di Pisa
wiley   +1 more source

Magnetic resonance imaging of myocardial strain after acute ST-segment-elevation myocardial infarction: a systematic review [PDF]

, 2017
The purpose of this systematic review is to provide a clinically relevant, disease-based perspective on myocardial strain imaging in patients with acute myocardial infarction or stable ischemic heart disease.
Auger, Daniel A., Berry, Colin, Epstein, Frederick H., Mangion, Kenneth, McComb, Christie   +4 more
core   +1 more source

Investigating the cell of origin and novel molecular targets in Merkel cell carcinoma: a historic misnomer

Molecular Oncology, EarlyView.
This study indicates that Merkel cell carcinoma (MCC) does not originate from Merkel cells, and identifies gene, protein & cellular expression of immune‐linked and neuroendocrine markers in primary and metastatic Merkel cell carcinoma (MCC) tumor samples, linked to Merkel cell polyomavirus (MCPyV) status, with enrichment of B‐cell and other immune cell
Richie Jeremian, Sriraam Sivachandran, Melissa Galati, Brandon Ramchatesingh, Hibo Rijal, Johnny Hanna, Elena Netchiporouk, May Chergui, Margaret Redpath, Samy Abou Setah, Ivan V. Litvinov   +10 more
wiley   +1 more source

Defining circulating mononuclear cells in heart failure through single-cell RNA sequencing: new insights for an old disease [PDF]

, 2020
Cristina Panico, Marinos Kallikourdis, Gianluigi Condorelli   +2 more
openalex   +1 more source

2021 ESC/EACTS Guidelines for the management of valvular heart disease.

European Heart Journal, 2021
A. Vahanian, F. Beyersdorf, F. Praz, M. Milojevic, S. Baldus, J. Bauersachs, D. Capodanno, L. Conradi, M. de Bonis, R. de Paulis, V. Delgado, N. Freemantle, M. Gilard, K. Haugaa, A. Jeppsson, P. Jüni, L. Pierard, B. Prendergast, J. R. Sádaba, C. Tribouilloy, W. Wojakowski, Franz‐Josef Neumann, Pat A Myers, M. Abdelhamid, S. Achenbach, R. Asteggiano, F. Barili, M. Borger, T. Carrel, J. Collet, Dan Foldager, G. Habib, C. Hassager, A. Irs, B. Iung, M. Jahangiri, H. Katus, Konstantinos C. Koskinas, S. Massberg, Christian Mueller, J. Nielsen, P. Pibarot, A. Rakisheva, M. Roffi, A. Rubboli, E. Shlyakhto, M. Siepe, M. Sitges, L. Sondergaard, M. Sousa‐Uva, G. Tarantini, J. Zamorano   +51 more
semanticscholar   +1 more source

Predictors of response and rational combinations for the novel MCL‐1 inhibitor MIK665 in acute myeloid leukemia

Molecular Oncology, EarlyView.
This study characterizes the responses of primary acute myeloid leukemia (AML) patient samples to the MCL‐1 inhibitor MIK665. The results revealed that monocytic differentiation is associated with MIK665 sensitivity. Conversely, elevated ABCB1 expression is a potential biomarker of resistance to the treatment, which can be overcome by the combination ...
Joseph Saad, Rhiannon Newman, Elmira Khabusheva, Sofia Aakko, Eric Durand, Mahesh Tambe, Heikki Kuusanmäki, Alun Parsons, Juho J. Miettinen, Komal Kumar Javarappa, Ezgi June Olgac, Nemo Ikonen, Mika Kontro, Kimmo Porkka, Heiko Maacke, Janghee Woo, Ensar Halilovic, Caroline A. Heckman   +17 more
wiley   +1 more source

Triglyceride glucose index for predicting cardiovascular outcomes after percutaneous coronary intervention in patients with type 2 diabetes mellitus and acute coronary syndrome

Cardiovascular Diabetology, 2020
Background The triglyceride glucose (TyG) index, a simple surrogate estimate of insulin resistance, has been demonstrated to predict cardiovascular (CV) disease morbidity and mortality in the general population and many patient cohorts.
Xiaoteng Ma, Lisha Dong, Qiaoyu Shao, Yujing Cheng, Sai Lv, Yan Sun, Hua Shen, Zhijian Wang, Yujie Zhou, Xiaoli Liu   +9 more
doaj   +1 more source

Cholesterol and coronary heart disease: screening and treatment [PDF]

, 1998
Coronary heart disease (CHD) is a major cause of morbidity and mortality in the United Kingdom, accounting for just under one quarter of all deaths in 1995: 27% among men and 21% among women.1 Although many CHD deaths occur among elderly people, CHD ...
Ebrahim, S., Lampe, F., McCabe, C., Payne, N., Pickin, M., Sampson, F., Sheldon, T.A., Smith, G.D., Wannamthee, G., Ward, S.   +9 more
core   +2 more sources

Liquid biopsy epigenetics: establishing a molecular profile based on cell‐free DNA

Molecular Oncology, EarlyView.
Cell‐free DNA (cfDNA) fragments in plasma from cancer patients carry epigenetic signatures reflecting their cells of origin. These epigenetic features include DNA methylation, nucleosome modifications, and variations in fragmentation. This review describes the biological properties of each feature and explores optimal strategies for harnessing cfDNA ...
Christoffer Trier Maansson, Anders Lade Nielsen, Boe Sandahl Sorensen   +2 more
wiley   +1 more source