Results 41 to 50 of about 12,031,157 (316)

Disordered but rhythmic—the role of intrinsic protein disorder in eukaryotic circadian timing

FEBS Letters, EarlyView.
Unstructured domains known as intrinsically disordered regions (IDRs) are present in nearly every part of the eukaryotic core circadian oscillator. IDRs enable many diverse inter‐ and intramolecular interactions that support clock function. IDR conformations are highly tunable by post‐translational modifications and environmental conditions, which ...
Emery T. Usher, Jacqueline F. Pelham
wiley   +1 more source

Urine chloride trajectory and relationship with diuretic response in acute heart failure

ESC Heart Failure
Aims Sodium excretion is a well‐defined marker used to assess diuretic response in acute heart failure (AHF). Despite a strong pathophysiological background, the role of urine chloride excretion has not been described and established yet.
Mateusz Guzik, Robert Zymliński, Piotr Ponikowski, Jan Biegus   +3 more
doaj   +1 more source

Investigating the cell of origin and novel molecular targets in Merkel cell carcinoma: a historic misnomer

Molecular Oncology, EarlyView.
This study indicates that Merkel cell carcinoma (MCC) does not originate from Merkel cells, and identifies gene, protein & cellular expression of immune‐linked and neuroendocrine markers in primary and metastatic Merkel cell carcinoma (MCC) tumor samples, linked to Merkel cell polyomavirus (MCPyV) status, with enrichment of B‐cell and other immune cell
Richie Jeremian, Sriraam Sivachandran, Melissa Galati, Brandon Ramchatesingh, Hibo Rijal, Johnny Hanna, Elena Netchiporouk, May Chergui, Margaret Redpath, Samy Abou Setah, Ivan V. Litvinov   +10 more
wiley   +1 more source

Inflammatory responses and inflammation-associated diseases in organs

OncoTarget, 2015
Inflammation is a biological response of the immune system that can be triggered by a variety of factors, including pathogens, damaged cells and toxic compounds. These factors may induce acute and/or chronic inflammatory responses in the heart, pancreas,
Linlin Chen, H. Deng, H. Cui, J. Fang, Z. Zuo, J. Deng, Yinglun Li, Xun Wang, Ling Zhao   +8 more
semanticscholar   +1 more source

The ACCEPTance of automation: refining circulating tumor cells enumeration for improved metastatic colorectal cancer prognosis

Molecular Oncology, EarlyView.
This study highlights the potential of automated enumeration using the ACCEPT software to refine circulating tumor cell (CTC) detection in metastatic colorectal cancer (mCRC). The automated method demonstrates improved accuracy and reduced variability compared to the manual approach.
Michela De Meo, Marco Siringo, Alessandro Vici, Ann Zeuner, Orietta Gandini, Paola Gazzaniga, Chiara Nicolazzo   +6 more
wiley   +1 more source

Implications of prognostic nutritional index in predicting adverse outcomes of uncontrolled diabetic patients: a cohort study of the national health and nutrition examination survey from 2005 – 2018

Diabetology & Metabolic Syndrome
Background Diabetes mellitus (DM) is a metabolic disorder with increasing prevalence and poor control rates, leading to adverse events. Prognostic nutritional value (PNI) has been identified as a protective factor in DM, but its role in uncontrolled DM ...
Fei Liu, Zhili Jiang, Wei Luo, Yunxiao Yang, Shuai Guo, Jiayi Yi, Geng Shen, Wei Li, Lin Wang, Xiuhuan Chen, Zhaogong Zhi, Tian Liu, Xuedong Zhao, Chen Li, Hai Gao   +14 more
doaj   +1 more source

2013 ACC/AHA Guideline on the Assessment of Cardiovascular Risk: A Report of the American College of Cardiology/American Heart Association Task Force on Practice Guidelines

Circulation, 2014
Preamble and Transition to ACC/AHA Guidelines to Reduce Cardiovascular Risk S50 The goals of the American College of Cardiology (ACC) and the American Heart Association (AHA) are to prevent cardiovascular diseases (CVD); improve the management of people
D. Goff, D. Lloyd‐Jones, G. Bennett, S. Coady, R. D'Agostino, R. Gibbons, P. Greenland, D. Lackland, D. Levy, C. O’Donnell, Jennifer G. Robinson, J. Schwartz, Susan T. Shero, Sidney C. Smith, P. Sorlie, N. Stone, Peter W. F. Wilson, Harmon S. Jordan, Lev Nevo, Janusz Wnek, Jeffrey L. Anderson, L. Halperin, Nancy M. Albert, Biykem Bozkurt, R. Brindis, Lesley H. Curtis, D. Demets, J. Hochman, Richard J. Kovacs, E. M. Ohman, S. Pressler, Frank W. Sellke, Win-Kuang Shen   +32 more
semanticscholar   +1 more source

Periodontitis and cardiovascular diseases: Consensus report

Journal of Clinical Periodontology, 2020
Background In Europe cardiovascular disease (CVD) is responsible for 3.9 million deaths (45% of deaths), being ischaemic heart disease, stroke, hypertension (leading to heart failure) the major cause of these CVD related deaths.
M. Sanz, Álvaro Marco del Castillo, S. Jepsen, J. González-Juanatey, F. D’Aiuto, P. Bouchard, I. Chapple, T. Dietrich, I. Gotsman, F. Graziani, D. Herrera, B. Loos, P. Madianos, J. Michel, P. Perel, B. Pieske, L. Shapira, M. Shechter, M. Tonetti, C. Vlachopoulos, G. Wimmer   +20 more
semanticscholar   +1 more source

Predictors of response and rational combinations for the novel MCL‐1 inhibitor MIK665 in acute myeloid leukemia

Molecular Oncology, EarlyView.
This study characterizes the responses of primary acute myeloid leukemia (AML) patient samples to the MCL‐1 inhibitor MIK665. The results revealed that monocytic differentiation is associated with MIK665 sensitivity. Conversely, elevated ABCB1 expression is a potential biomarker of resistance to the treatment, which can be overcome by the combination ...
Joseph Saad, Rhiannon Newman, Elmira Khabusheva, Sofia Aakko, Eric Durand, Mahesh Tambe, Heikki Kuusanmäki, Alun Parsons, Juho J. Miettinen, Komal Kumar Javarappa, Ezgi June Olgac, Nemo Ikonen, Mika Kontro, Kimmo Porkka, Heiko Maacke, Janghee Woo, Ensar Halilovic, Caroline A. Heckman   +17 more
wiley   +1 more source

Comparing Performance of Data Mining Algorithms in Prediction Heart Diseases

, 2015
Heart diseases are among the nation’s leading couse of mortality and moribidity. Data mining teqniques can predict the likelihood of patients getting a heart disease.
Moloud Abdar, S. R. N. Kalhori, Tole Sutikno, Imam Much Ibnu Subroto, G. Arji   +4 more
semanticscholar   +1 more source