Results 51 to 60 of about 1,419,649 (316)

pH‐mediated activation of the lysosomal arginine sensor SLC38A9

FEBS Letters, EarlyView.
Cells monitor nutrient levels via the lysosomal transporter SLC38A9 to activate the mechanistic target of rapamycin complex 1 (mTORC1). This study reveals that SLC38A9 function is regulated by pH. We identified histidine 544 as a critical pH sensor that undergoes conformational changes to control amino acid efflux from lysosomes; therefore, it ...
Xuelang Mu, Ampon Sae Her, Tamir Gonen
wiley   +1 more source

Optimizing MitraClip Outcomes: The Case for Routine Iatrogenic ASD Closure

Clinical Medicine Insights: Cardiology
Introduction: Iatrogenic atrial septal defect (iASD) resulting from MitraClip procedures may cause volume overload and deterioration of right ventricular (RV) function.
Witold Streb, Roland Fiszer, Katarzyna Mitręga, Tomasz Podolecki, Tomasz Kurek, Monika Lazar, Wiktoria Kowalska, Anna Wizner, Anita Stanjek-Cichoracka, Zbigniew Kalarus   +9 more
doaj   +1 more source

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

Spot urine sodium as a marker of urine dilution and decongestive abilities in acute heart failure

Scientific Reports
The decongestion ability in response to diuretic treatment plays a crucial role in the treatment of acute heart failure. This effectiveness is evaluated through the assessment of sodium concentration and urine volume, which are also treatment goals ...
Mateusz Guzik, Gracjan Iwanek, Marat Fudim, Robert Zymliński, Dominik Marciniak, Piotr Ponikowski, Jan Biegus   +6 more
doaj   +1 more source

Rationale, design and conduct of a randomised controlled trial evaluating a primary care-based complex intervention to improve the quality of life of heart failure patients: HICMan (Heidelberg Integrated Case Management) : study protocol

, 2007
Background: Chronic congestive heart failure (CHF) is a complex disease with rising prevalence, compromised quality of life (QoL), unplanned hospital admissions, high mortality and therefore high burden of illness. The delivery of care for these patients
Herzog, Wolfgang, Szecsenyi Joachim, Gensichen, Jochen, Christiane Muth, Joachim Szecsenyi, Müller-Tasch, Thomas, Schellberg Dieter, Thomas Müller-Tasch, Schellberg, Dieter, Szecsenyi, Joachim, Herzog Wolfgang, Peters-Klimm Frank, Peters-Klimm, Frank, Dieter Schellberg, Frank Peters-Klimm, Jochen Gensichen, Wolfgang Herzog, Gensichen Jochen, Muth, Christiane, Muth Christiane, Müller-Tasch Thomas   +20 more
core   +1 more source

E2A selectively regulates TGF‐β–induced apoptosis in KRAS‐mutant non‐small cell lung cancer

Molecular Oncology, EarlyView.
Ability to induce apoptosis by TGF‐β is frequently lost in advanced lung adenocarcinoma despite intact TGF‐β signaling. We identify E2A as a mutant KRAS–dependent mediator of resistance to TGF‐β–induced apoptosis. TGF‐β induces E2A via SMAD3 in mutant KRAS cells, and E2A silencing restores apoptosis and enhances radiation response in cell lines ...
Sergei Chuikov, Shiva Krishna Katkam, Zhefan Wang, Venkateshwar G. Keshamouni   +3 more
wiley   +1 more source

On Fatty Diseases of the Heart [PDF]

Journal of the Royal Society of Medicine
n ...
openaire   +4 more sources

Human myocardial protein pattern reveals cardiac diseases [PDF]

, 2012
Proteomic profiles of myocardial tissue in two different etiologies of heart failure were investigated using high performance liquid chromatography (HPLC)/Fourier transform ion cyclotron resonance mass spectrometry (FT-ICR MS).
Bergquist, Maria, Baykut, Doan,, Bergquist, Maria,, Witt, Matthias,, Baykut, Doan, Mayer, Franz-Josef,, Bergquist, Jonas, Baykut, Gökhan, Mayer, Franz-Josef, Witt, Matthias, Baykut, Gökhan,, Bergquist, Jonas,   +11 more
core   +1 more source

Flow Enabled Target Capture Halbach‐based magnetic enrichment increases circulating tumor cell capture from blood in metastatic cancer patients

Molecular Oncology, EarlyView.
Pair‐wise comparison of the CellSearch and FETCH enrichment technologies for circulating tumor cells (CTCs) from metastatic breast, prostate, and small cell lung cancer patients shows an increased capture of CTCs using FETCH enrichment. The clinical implementation of circulating tumor cells (CTCs) as a predictive tool for therapy efficacy in the ...
Michiel Stevens, Anouk Mentink, Tom Niessink, Frank Coumans, Leonie Mekenkamp, Ruchi Bansal, Jeroen Hiltermann   +6 more
wiley   +1 more source

Spot urine sodium‐to‐creatinine ratio surpasses sodium in identifying poor diuretic response in acute heart failure

ESC Heart Failure
Aims We aim to identify the most accurate marker for early prediction of poor diuretic response in acute heart failure (AHF) patients with signs of congestion requiring intravenous diuretic treatment.
Gracjan Iwanek, Mateusz Guzik, Robert Zymliński, Marat Fudim, Piotr Ponikowski, Jan Biegus   +5 more
doaj   +1 more source