Results 101 to 110 of about 187,398 (301)

PET Imaging of Cardiac Inflammation in Viral Myocarditis Using a DPP4‐Targeted Probe

Advanced Science, EarlyView.
This study describes a DPP4‐targeted PET probe for imaging myocardial inflammation by selectively targeting activated immune cells. Derived from the clinically approved small‐molecule inhibitor linagliptin, the probe demonstrates favorable biodistribution with specific cardiac uptake in myocarditis.
Wanhao Gao, Wenzhu Hu, Du Tang, Xinxin Liu, Kun Yu, Lixia Feng, Minyu Liao, Wang Lin, Wenqiang Zhu, Sanjay Rajagopalan, Xiaoli Lan, Jixin Zhong, Dao Wen Wang, Dawei Jiang, Xiaoquan Rao   +14 more
wiley   +1 more source

Global Strain in Severe Aortic Valve Stenosis:Relation to Clinical Outcome after Aortic Valve Replacement [PDF]

, 2012
Background— Global longitudinal systolic strain (GLS) is often reduced in aortic stenosis despite normal ejection fraction. The importance of reduced preoperative GLS on long-term outcome after aortic valve replacement is unknown.
Dahl, Jordi S, Møller, Jacob Eifer, Pellikka, Patricia A, Poulsen, Mikael K, Rudbæk, Torsten R, Videbæk, Lars   +5 more
core   +1 more source

Methylglyoxal Accumulation is Associated with Brain Inflammation after Myocardial Infarction with Sex and Regional Differences

Advanced Science, EarlyView.
This study identifies that methylglyoxal may play an important role in heart‐brain interactions after myocardial infarction. Myocardial infarction leads to increased levels of methylglyoxal‐derived advanced glycation end‐products (MG‐H1) in the brain of mice, which is associated with loss of blood‐brain barrier integrity and neuroinflammation ...
Ramis Ileri, Xixi Guo, Erik J. Suuronen
wiley   +1 more source

Effects of vildagliptin on ventricular function in patients with type 2 diabetes mellitus and heart failure: a randomized placebo-controlled trial [PDF]

, 2017
Objectives: This study sought to examine the safety of the dipeptidyl peptidase-4 inhibitor, vildagliptin, in patients with heart failure and reduced ejection fraction.
Bolli, Geremia B., Kothny, Wolfgang, Kozlovski, Plamen, Krum, Henry, Lewsey, James D., Lukashevich, Valentina, McMurray, John J.V., Ponikowski, Piotr   +7 more
core   +2 more sources

Prevalence of stage B heart failure in patients undergoing echocardiography during regular clinical practice

Indian Heart Journal
Recognizing individuals with stage B heart failure (HF) is important to prevent or delay its progression to symptomatic HF. Unfortunately, no study at present describes the prevalence of stage B HF in Indian patients.
Rakesh Gupta, Tamoghna Das, Malvika K. Suchak, Smita Suraj Kudalkar, Prasenjit Pandey, Sameer Shrivastava, Manish Bansal, M.K. Das   +7 more
doaj   +1 more source

Engineering Approaches to Modify Immunomodulatory Functions of Mesenchymal Stromal Cells (MSCs): Tissue Regeneration and Clinical Application

Advanced Science, EarlyView.
Mesenchymal stromal cells (MSCs) show promise for treating immune‐related disorders through immunomodulation and tissue regeneration. This review gives a brief overview of current clinical approval of MSC therapies. It also discussed how bioengineering, including genetic modification, biomaterial delivery, extracellular vesicles, and iPSC‐derived MSCs,
Sichen Yang, Kejia Li, Ning Wang, Zhen Li, Zhiyong Zhang, Rocky S. Tuan, Yangzi Jiang   +6 more
wiley   +1 more source

Efficacy profile of ivabradine in patients with heart failure plus angina pectoris [PDF]

, 2016
Objectives: In the Systolic Heart Failure Treatment with the If Inhibitor Ivabradine Trial (SHIFT), slowing of the heart rate with ivabradine reduced cardiovascular death or heart failure hospitalizations among patients with systolic chronic heart ...
Borer, Jeffrey S., Böhm, Michael, Depre, Christophe, Dominjon, Fabienne, Ford, Ian, Komajda, Michel, Maya, Juan, Swedberg, Karl, Tavazzi, Luigi, Wu, Yuna   +9 more
core   +1 more source

Harnessing Phase Separation for the Development of High‐Performance Hydrogels

Advanced Science, EarlyView.
ABSTRACT Hydrogels are indispensable for the development of next‐generation bioelectronics, soft robotics, and biomedical devices, where their mechanical properties determine performance and reliability. Among strategies to enhance hydrogel mechanics, phase separation enables controlled heterogeneity resulting in gel networks that are reinforced by ...
Yue Shao, Yiming Ma, Baihao Shao, Molly M. Stevens   +3 more
wiley   +1 more source

Gender‐specific risks for incident cancer in patients with different heart failure phenotypes

ESC Heart Failure
Background There is conflicting evidence regarding whether heart failure (HF) increases the risk of developing cancer. Objective This study aimed to assess the association between HF and incident cancer, considering gender differences and HF phenotypes ...
Qin‐Fen Chen, Christos S. Katsouras, Chenyang Liu, Jingjing Shi, Xiaoqian Luan, Chao Ni, Hongxia Yao, Yingdan Lu, Wei‐Hong Lin, Xiao‐Dong Zhou   +9 more
doaj   +1 more source

Impact of Obstructive Sleep Apnea in Patients with Acute Heart Failure: A Nationwide Cohort Study

Hearts
Background/Objectives: Heart failure presents a significant public health challenge, affecting millions in the US, with projections of increasing prevalence and economic burdens. Obstructive sleep apnea (OSA) is highly prevalent among HF patients.
Abdulmajeed Alharbi, Nahush Bansal, Anas Alsughayer, Momin Shah, Waleed Alruwaili, Mohammed Mhanna, Halah Alfatlawi, Eun Seo Kwak, Ayman Salih, Mohanad Qwaider, Ragheb Assaly   +10 more
doaj   +1 more source