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Heart Failure With Reduced Ejection Fraction
JAMA, 2020Worldwide, the burden of heart failure has increased to an estimated 23 million people, and approximately 50% of cases are HF with reduced ejection fraction (HFrEF).Heart failure is a clinical syndrome characterized by dyspnea or exertional limitation due to impairment of ventricular filling or ejection of blood or both.
James L. Januzzi +2 more
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Heart Failure Without a Reduced Ejection Fraction
The American Journal of Managed Care, 2023Heart failure (HF) substantially impacts the health and financial security of an increasing proportion of the US population. It worsens debility and quality of life and may lead to hospitalization and death. HF is a clinical syndrome with diverse symptomatic presentations.
Sant, Kumar, Mitchell A, Psotka
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Heart failure with reduced ejection fraction
Nature Reviews Disease Primers, 2017Heart failure is a global public health problem that affects more than 26 million people worldwide. The global burden of heart failure is growing and is expected to increase substantially with the ageing of the population. Heart failure with reduced ejection fraction accounts for approximately 50% of all cases of heart failure in the United States and ...
James L. Januzzi +9 more
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blockers for heart failure with reduced ejection fraction [PDF]
BMJ, 2011 #### Case scenario A 74 year old man attends the surgery for review of his longstanding heart failure. He has an exercise tolerance of just a few yards, limited by breathlessness. His jugular venous pressure is not raised, he has no ankle oedema, and the lung bases are clear. There is no evidence of fluid overload.
James R. Waller, Derek G. Waller
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Vericiguat for the treatment of heart failure with reduced ejection fraction
Expert Review of Cardiovascular Therapy, 2023Despite significant therapeutic advancements in heart failure with reduced ejection fraction (HFrEF), the residual risk of all-cause mortality and hospitalizations remains high among patients with HFrEF. Vericiguat is a novel oral soluble guanylate cyclase (sGC) stimulator which was approved by the US Food and Drug administration (FDA) in January 2021 ...
Ahmed K. Siddiqi +5 more
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New pharmacotherapy for heart failure with reduced ejection fraction
Expert Review of Cardiovascular Therapy, 2020The European Society of Cardiology (ESC), Canadian Cardiovascular Society, and the American College of Cardiology Heart Failure (HF) guidelines all currently recommend the use of Angiotensin Converting Enzyme (ACE) inhibitors or Angiotensin Receptor Blockers (ARBs) and Beta Blockers (BB) in the treatment of HF with a reduced ejection fraction (HFrEF ...
Sara Sotirakos +3 more
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Hypertension in Patients with Heart Failure with Reduced Ejection Fraction
Current Cardiology Reports, 2016Hypertension (HTN) is a well-known health problem associated with considerable morbidity and mortality and it is an important risk factor for the development of heart failure (HF). These findings support the need for optimizing the antihypertensive strategies to prevent the progression to HF.
VOLPE, Massimo +2 more
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Heart Failure with Reduced Ejection Fraction
2019Heart failure with reduced ejection fraction (HF-REF) is a common problem worldwide and its prevalence rises with age. It is associated with substantial morbidity and mortality. Development of the condition is driven by a number of haemodynamic and neurohumoral pathophysiological processes which, in turn, lead to adverse remodelling of the myocardium ...
Pardeep S. Jhund, Alice M Jackson
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International Journal of Cardiology, 2011
[1] Cooper A, Calvert N, SKinner J, et al. Nice guideline: chest pain of recent onset: assessment of recent onset chest pain or discomfort of suspected cardiac origin; 2010. available at:http://www.nice.org.uk/nicemedia/live/12947/47931/47931.pdf. [2] Bourdillon PJ. NICE and chest pain diagnosis.
Daniela Miani +6 more
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[1] Cooper A, Calvert N, SKinner J, et al. Nice guideline: chest pain of recent onset: assessment of recent onset chest pain or discomfort of suspected cardiac origin; 2010. available at:http://www.nice.org.uk/nicemedia/live/12947/47931/47931.pdf. [2] Bourdillon PJ. NICE and chest pain diagnosis.
Daniela Miani +6 more
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Atrial arrhythmias in heart failure with a reduced ejection fraction
Current Opinion in Cardiology, 2020Purpose of review Atrial arrhythmias are common among individuals with heart failure with a reduced ejection fraction (HFrEF). This review describes management options for these arrhythmias and discusses emerging clinical data supporting catheter ablation.
Thomas A. Dewland, Babak Nazer
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