Results 181 to 190 of about 36,611 (218)

Polypharmacy in mice disrupts left ventricular function and structure and promotes proteome reorganisation in an age‐ and sex‐specific fashion

open access: yesBritish Journal of Pharmacology, Volume 182, Issue 19, Page 4625-4646, October 2025.
Background and Purpose Most older people use polypharmacy (≥5 medications), particularly those with cardiovascular disease. The effects of polypharmacy on the cardiovascular system are not well described. We examined the effect of a chronic polypharmacy regimen on left ventricular (LV) function, structure and proteome in young and old mice of both ...
Trang Tran   +9 more
wiley   +1 more source

Genetic findings of children with congenital heart diseases using chromosomal microarray and trio-based whole exome sequencing. [PDF]

open access: yesSci Rep
Guo R   +11 more
europepmc   +1 more source

Integration of ultrasound‐guided motion management into proton therapy treatment plans for ventricular tachycardia non‐invasive radio ablation

open access: yesJournal of Applied Clinical Medical Physics, Volume 26, Issue 9, September 2025.
Abstract Background Stereotactic arrhythmia radioablation (STAR) is an emerging, non‐invasive treatment for refractory ventricular arrhythmias. The technology requires target motion management. Purpose We studied the integration of a novel ultrasound probe and holder for heart motion management into proton‐beam STAR treatment plans.
Eleonora Rossi   +17 more
wiley   +1 more source

Gut Metabolite Indole‐3‐Propionic Acid Regulates Macrophage Autophagy Through PPT1 Inhibiting Aging‐Related Myocardial Fibrosis

open access: yesAdvanced Science, Volume 12, Issue 34, September 11, 2025.
IPA is an intestinal tryptophan metabolite whose effects decline with decreased heart function. Supplementing IPA can alleviate the aging‐related myocardial fibrosis through PPT1. PPT1 is a key protein localized to lysosomes, and IPA can restore macrophage autophagy function by regulating PPT1 expresssions, thereby reducing aging‐related myocardial ...
Jing Lu   +16 more
wiley   +1 more source

Phenotypic Characterization of Seven Pediatric Patients Diagnosed With KAT6B ‐Related Disorders: Case Series and Review of the Literature

open access: yesAmerican Journal of Medical Genetics Part A, Volume 197, Issue 9, September 2025.
ABSTRACT Genitopatellar syndrome (GPS) and Say‐Barber‐Biesecker‐Young‐Simpson Syndrome (SBBYSS) are clinically distinct neurodevelopmental disorders caused by monoallelic pathogenic variants in KAT6B. In some cases, GPS and SBBYSS features can overlap, determining an intermediate phenotype.
Vittorio Maglione   +12 more
wiley   +1 more source

Early Stent Frame Fracture of SAPIEN 3 Valve in the Pulmonary Position

open access: yesCatheterization and Cardiovascular Interventions, Volume 106, Issue 3, Page 1892-1893, September 1, 2025.
ABSTRACT A 15‐year‐old post‐REV patient underwent transcatheter pulmonary valve replacement with a 23 mm SAPIEN 3 for right ventricular outflow tract (RVOT) stenosis and severe regurgitation. At 9 months, recurrent stenosis revealed multiple frame fractures.
Raymond N. Haddad   +3 more
wiley   +1 more source

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