Results 41 to 50 of about 1,706,419 (254)

An epithelial GPR35 isoform supports tumor‐associated transcriptional and metabolic phenotypes

FEBS Letters, EarlyView.
GPR35 generates two functionally distinct isoforms with previously unresolved roles. GPR35‐short mediates immune‐cell chemotaxis, while GPR35‐long is enriched in colorectal cancer epithelium, where it supports increased metabolism, proliferation, and tumor‐associated transcriptional programs.
Jørgen D. Rønneberg, Martine Hjeltnes, Josephine Krieger, Joshua E. Elias, Maria Stensland, Kristian Holm, Xiaojun Jiang, Chuki Khangsar, Tuula A. Nyman, Arthur Kaser, Johannes R. Hov, Tom H. Karlsen, Nicole C. Kaneider, Frode L. Jahnsen, Georg Schneditz   +14 more
wiley   +1 more source

Skin Cancer Development in Solid Organ Transplant Recipients in Switzerland (Swiss Transplant Cohort Study). [PDF]

, 2020
IMPORTANCE Skin cancer, in particular squamous cell carcinoma, is the most frequent malignancy among solid organ transplant recipients with a higher incidence compared to the general population.
Hunger, R.E., Dickenmann, Michael, Nägeli, M., Harms, Mirjam, Arnold, Andreas W, Stenz, N.A., Arnold, A.W., Harms, M., Hofbauer, Günther F L, Laffitte, Emmanuel, Gaide, Olivier, Hofbauer, GFL, Laffitte, E., Gaide, O., Hunger, Robert E., Hofbauer, Günther F L; https://orcid.org/, Cozzio, Antonio, Nägeli, Mirjam, Stampf, S., Stampf, Susanne, Mühlstädt, Michael, Hunger, Robert E, Mühlstädt, M., Laffitte, Emmanuel Alexis, Stenz, Nadja Angela, the Swiss Transplant Cohort Study, Dickenmann, M., Cozzio, A.   +27 more
core   +2 more sources

Liver organoids: modelling complexity in homeostasis and disease

FEBS Letters, EarlyView.
Studying liver in vitro has been challenging because simple 2D cell cultures fail to capture liver's cellular and architectural complexity. To bridge this gap, scientists increasingly use organoids, 3D liver models which better mimic liver composition and function. This review examines recent advances in liver organoid complexity and realism, discusses
Anna M. Dowbaj, Meritxell Huch
wiley   +1 more source

Triple ECMO therapy and emergency PCI performed perioperatively during pediatric heart transplantation

IHJ Cardiovascular Case Reports, 2019
8 years boy, a case of dilated cardiomyopathy with severe biventricular dysfunction awaiting heart transplantation, sustained cardiac arrest. He was initiated on central ECMO, stabilised and then heart transplantation was performed. In the immediate post-
Babu Ezhumalai, Suresh Rao, Komarakshi Rajagopalan Balakrishnan   +2 more
doaj   +1 more source

Prevalence of pulmonary hypertension in patients with COVID‐19 related lung disease listed for lung transplantation: A UNOS registry analysis

Pulmonary Circulation, 2023
COVID‐19 related lung disease (CRLD) has emerged as an indication for lung transplantation (LT) in highly select patients. The prevalence and prognostic implication of coexisting pulmonary hypertension (PH) in patients with CRLD listed for LT is not ...
Christopher Thomas, Abhimanyu Chandel, Christopher S. King, Shambhu Aryal, A. Whitney Brown, Vikramjit Khangoora, Alan Nyquist, Anju Singhal, Onix Cantres Fonseca, Oksana Shlobin, Steven D. Nathan   +10 more
doaj   +1 more source

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

Anaesthetics considerations for organ retrieval in the voluntary assisted dying patient – case report

BMC Anesthesiology
Background Voluntary assisted dying (VAD) is now legalised in several countries. Organ donation after VAD provides unique moral and logistical challenges. This report highlights the role of the anaesthetist in such cases.
Adam B Levin, Yashutosh Joshi, Nikunj Vaidhya, Joanne Kantianis, Peter S Macdonald   +4 more
doaj   +1 more source

Oral milrinone for management of refractory right ventricular failure in patients with left ventricular assist devices

ESC Heart Failure, 2022
Aims We present a single‐centre retrospective experience using oral milrinone in patients with a left ventricular assist device (LVAD) and concurrent refractory right ventricular failure.
Waqas Akhtar, Charles Butcher, Andrew Morley‐Smith, Fernando Riesgo Gil, Owais Dar, Veronica Baston, John Dunning, Haifa Lyster   +7 more
doaj   +1 more source

PANoptosis in the pathogenesis of myelodysplastic syndromes

Molecular Oncology, EarlyView.
PANoptosis, a combination of three types of programmed cell death, is mediated by a large protein complex called a PANoptosome. In healthy bone marrow hematopoietic cells, PANoptosis is restricted by inhibitory signaling. In MDS, bone marrow cells become sensitive to the PANoptotic stimuli due to the aberrant inactivation of inhibitory signaling or ...
Rohit Thalla, Jyoti Lamichhane, Cameron Lewis, Peter Breslin, Jiwang Zhang   +4 more
wiley   +1 more source

Impact of SARS-CoV-2-Related Hygiene Measures on Community-Acquired Respiratory Virus Infections in Lung Transplant Recipients in Switzerland

, 2023
Background and Objectives: Community-acquired respiratory virus (CARV) infections pose a serious risk for lung transplant recipients (LTR) as they are prone to severe complications.
The Swiss Transplant Cohort Study, Paola Gasche-Soccal, Macé M. Schuurmans, Isabelle Baumann, René Hage, Baumann, I., The Swiss Transplant Cohort Study The Swiss Transplant Cohort Study, Aubert, J.D., John-David Aubert, Gasche-Soccal, P., Hage, R., Schuurmans, M.M.   +11 more
core   +1 more source