Results 131 to 140 of about 2,071,977 (304)

Isolated Cardiac Sarcoidosis in Heart Transplantation

, 2014
Background. Heart transplantation is the ultimate treatment for end-stage heart failure. Cardiac sarcoidosis has rarely been reported in heart transplantation worldwide. Their long-term prognosis after heart transplantation is unknown.
Chang, T. -I.;Chi, N. -H.;Chou, N. -K.;Tsao, C. -I.;Yu, H. -Y.;Chen, Y. -S.;Wang, S. -S., 紀乃新;虞希禹;陳益祥;周迺寬;王水深   +1 more
core   +1 more source

Proteogenomic Profiling of Idiopathic Pulmonary Arterial Hypertension Identifies Sex‐Differential Proteins and Candidate Therapeutic Targets

Advanced Science, EarlyView.
An integrated proteogenomic analysis of 44,137 predominantly European‐ancestry UK Biobank participants aged 40–69 years identifies 12 robust proteins associated with idiopathic pulmonary arterial hypertension. These proteins define a high‐mortality molecular endotype, support early detection and mortality prediction, reveal sex‐differential proteomic ...
Xinjie Lin, Yangchang Zhang, Yang Pu, Duanke Liu, Tao Lei, Kai Ma, Qiyu He, Zheng Dou, Yuze Liu, Dengyuan Liu, Yinge He, Yanshang Wang, Xiaojiao Zheng, Yanbing Ma, Jianrong Zhou, Weiding Zhai, Binbin Su, Li Chen, Shoujun Li   +18 more
wiley   +1 more source

Bridging to heart transplantation from the biventricular pulsatile berlin heart EXCOR assist device support in a patient with advanced end-organ failure

, 2015
Long-term mechanical circulatory support is a life-saving technology while briding to heart transplantation. It increases the quality of life and preserves end-organ function for patients with advanced heart failure.
Demirozu Z.T., Kucukaksu D.S.
core  

Collagen‐Binding IL‐15 Immunocytokine Armed Oncolytic Adenovirus Establishes a Self‐Reinforcing Immunostimulatory Milieu to Potentiate Antitumor Immunity

Advanced Science, EarlyView.
Repurposing the dense tumor stroma from a physical barrier into an anchoring scaffold, an engineered oncolytic adenovirus encoding IL15C‐CBD overcomes the immunosuppressive microenvironment in triple‐negative breast cancer. Intratumoral viral replication secretes this collagen‐anchored immunocytokine, forming a localized cytokine depot.
Yaqi Yang, Xiaoxiao Liu, Junqiang Ding, Jinliang Xu, Jianhua Zhang, Hanchang Zhang, Rong Yang, Sha Li, Lu Zheng, Runping Su, Yue Zhao, Jianxiao Wu, Hao Li, Changyou Zhan, Xihui Gao   +14 more
wiley   +1 more source

An Extracellular Pore‑Targeting Peptide Defines a Designable Allosteric Site in TRPV2

Advanced Science, EarlyView.
Structure‐guided peptide engineering yields Depiv2, a highly potent and subtype‐selective TRPV2 inhibitor that binds to the extracellular pore and remodels it into a closed, non‐conductive state. Depiv2 suppresses pathological cardiac hypertrophy, establishing the TRPV2 outer pore as a designable interface for selective peptide modulation.
Aiqin Zhu, Hongkun Wang, Jiawei Wang, Xiaolu Liu, Aerziguli Aierken, Lizhen Xu, Ping Liang, Fan Yang   +7 more
wiley   +1 more source

Summary of the International Society for Heart and Lung Transplantation (ISHLT) Consensus Conference on Graft Dysfunction within the First 72 hours after Heart Transplantation : A 10-year Update

Primary graft dysfunction (PGD), defined as ventricular dysfunction occurring within 24 hours after heart transplantation (HTx) in the absence of identifiable secondary causes, remains a major contributor to early post-transplant mortality. Over the past
Hsich, Eileen, Zuckermann, Andreas, Consensus Conference participants, Kobashigawa, Jon, Chang, Patricia P, Manla, Yosef, Kittleson, Michelle, Potena, Luciano, Berman, Marius, Esmailian, Fardad, MacDonald, Peter S, Trahanas, John, Leprince, Pascal, Nilsson, Johan, Ardehali, Abbas, Shah, Ashish, Martin-Suarez, Sofia, Segovia-Cubero, Javier, Khush, Kiran, Moayedi, Yasbanoo, Farr, Maryjane, Hall, Shelley, Hsich, Eileen,, Chang, Patricia P,, Kittleson, Michelle,, Berman, Marius,, MacDonald, Peter S,, Farr, Maryjane,, Martin-Suarez, Sofia,, Leprince, Pascal,, Potena, Luciano,, Trahanas, John,, Hall, Shelley,, Khush, Kiran,, Moayedi, Yasbanoo,, Shah, Ashish,, Manla, Yosef,, Segovia-Cubero, Javier,, Nilsson, Johan,, Kobashigawa, Jon,, Zuckermann, Andreas,, Ardehali, Abbas,, Lund University., Esmailian, Fardad,   +43 more
core   +1 more source

Smart Bioinks for 4D Bioprinting: Requirements, Design, and Applications

Advanced Science, EarlyView.
Smart bioinks empower 4D‐bioprinted constructs to dynamically adapt and remodel in response to stimuli, effectively biomimicking native tissues. Artificial Intelligence (AI) and Machine Learning (ML) play a guiding role in their rational design by optimizing relevant properties.
Shangsi Chen, Jiahui Lai, Qiongjiao Zeng, Liangbin Zhou, Boguang Yang, Bin Zhang, Min Wang, Jiajing Zhou, Kieran Lau, Khoon S. Lim, Zhong Alan Li, Rocky S. Tuan   +11 more
wiley   +1 more source

Dual Repression by IPA1 Fine‐Tunes OsbZIP79‐Mediated Salt Tolerance in Rice

Advanced Science, EarlyView.
Dual repression by IPA1 fine‐tunes OsbZIP79‐mediated salt tolerance in rice: direct transcriptional inhibition under normal conditions and salt‐induced degradation under stress. This dual mechanism activates OsbZIP79 to regulate Na+/K+ homeostasis and redox balance via downstream genes, enabling optimal salt stress response.
Hui Wang, Bo Liu, Can Hu, Chenfan Zheng, Yuting Wei, Xier Xu, Wei Yang, Yu Fang, Guangle Shen, Pedro García‐Caparros, Conghe Zhang, Qingyao Shu, Meng Jiang   +12 more
wiley   +1 more source

The utility of a pleural carcinomatosis score for assessing resectability

Pleura and Peritoneum
Malignant pleural effusion is a common evolution of various cancers and is associated with poor prognosis and quality of life. Currently, the surgical approach is mainly palliative, involving videothoracoscopic talc pleurodesis or the insertion of ...
Drevet Gabrielle, Belaroussi Yaniss, Soldea Valentin, Kovacs Erik, Grima Renaud, Maury Jean-Michel, Tronc François   +6 more
doaj   +1 more source

A Gut‐Brain Axis Underlying Succinate‐Associated Compulsive‐Like Behavior

Advanced Science, EarlyView.
Gut‐derived succinate is associated with an excitatory‐inhibitory imbalance in dmPFC glutamatergic neurons, involving microglial SUCNR1 activation and vagal afferent signaling via upregulated gut 5‐HT4 receptors along the DVC‐CeA‐dmPFC circuit, changes that are linked to excessive compulsive‐like behavior.
Yi Li, Ying‐Dan Zhang, Wei Wang, Xin‐Yi Wu, Di Li, Xin Gong, Fei Tian, Meng‐Yu Dai, Jian Gao, Zi‐Feng Zheng, Zi‐Yang Bi, Dong‐Dong Shi, Zhen Wang   +12 more
wiley   +1 more source