Results 91 to 100 of about 1,690,662 (299)

Biological tissue mechanics with fibres modelled as one dimensional Cosserat continua: applications to cardiac tissue in healthy and diseased states [PDF]

, 2014
Includes bibliographical references.Classically, the elastic behaviour of cardiac tissue mechanics is modelled using anisotropic strain energy functions capturing the averaged behaviour of its fibrous microstructure.
Sack, Kevin
core   +1 more source

Peculiarities of macro- and cytometric assessment of morphological structures of the domestic pig heart

Regulatory Mechanisms in Biosystems
The cardiovascular system, which includes the heart, is one of the essential systems of the human and animal body. With its participation, the blood supply of the organs takes place; it promotes the outflow of lymph from the organs and its transport into
L. P. Horalskyi, M. R. Ragulya, N. L. Kolesnik, I. M. Sokulskyi, B. V. Gutyj   +4 more
doaj   +1 more source

Therapeutic efficacy of TBC3711 in monocrotaline-induced pulmonary hypertension [PDF]

, 2011
Background: Endothelin-1 signalling plays an important role in pathogenesis of pulmonary hypertension. Although different endothelin-A receptor antagonists are developed, a novel therapeutic option to cure the disease is still needed.
Norbert Weissmann, Sydykov, Akylbek, Brandes, Ralf, Schermuly, Ralph T., Hossein A Ghofrani, Janssen, Wiebke, Seeger Werner, Ralf P Brandes, Neil Davie, Dahal, Bhola K., Davie, Neil, Janssen Wiebke, Davie Neil, Ghofrani Hossein A, Seeger, Werner, Cornitescu, Teodora, Brandes Ralf P, Cornitescu Teodora, Kosanovic, Djuro, Kojonazarov, Baktybek, Werner Seeger, Friedrich Grimminger, Ghofrani, Hossein Ardeschir, Grimminger, Friedrich, Dahal Bhola K, Djuro Kosanovic, Baktybek Kojonazarov, Teodora Cornitescu, Schermuly Ralph T, Sydykov Akylbek, Wiebke Janssen, Grimminger Friedrich, Akylbek Sydykov, Kojonazarov Baktybek, Weissmann Norbert, Himal Luitel, Luitel Himal, Ralph T Schermuly, Luitel, Himal, Weißmann, Norbert, Bhola K Dahal, Kosanovic Djuro   +41 more
core   +2 more sources

Intelligent Micro/Nanorobots for Targeted Interventional Therapy: From Bench to Clinic

Advanced Robotics Research, EarlyView.
Zirui Zhang et al. reviewed the application and challenges of mobile nanomachines in interventional therapy. By converting exogenous energy, including chemical, magnetic, optical, and ultrasonic sources, into mechanical forces, micro/nanorobots (MNRs) enable precise actuation at unprecedented scales. Evolving far beyond traditional drug delivery, these
Zirui Zhang, Yu Dong, Yongsheng Du, Rui Gao, Lin Zhang, Fei Tong   +5 more
wiley   +1 more source

Isolated double chambered right ventricle as a rare cause of sudden death in infancy

Egyptian Journal of Forensic Sciences, 2016
Isolated double-chambered right ventricle (DCRV) is a rare form of congenital heart disorder in which the right ventricle is divided into a high-pressure inlet portion and a low-pressure outlet portion by an anomalous muscle bundle. Rarely, autopsy cases
W. Thaljawi, M. Belhadj, Y. Chkirben, S. Bouslema, M. Jedidi, T. Masmoudi, M.K Souguir, M.T. Yaâcoubi, M. Ben Dhiab   +8 more
doaj   +1 more source

Innate Immunocompetent hiPSC‐Derived Neurospheroids Capture Early CNS Responses to rAAV

Advanced Science, EarlyView.
Knowledge of human CNS immune responses to AAV‐based gene therapies remains limited due to the lack of immune‐competent human models. Here, a hiPSC‐derived 3D neuroimmune platform integrating neurospheroids and microglia is established using stirred‐tank bioreactors.
Catarina M. Gomes, Gabriela Silva, Mafalda Aleixo, Marta Gomes, Daniel Simão, Stephan J. Holtkamp, Diana D. Lobo, Pradeep Harish, Rosalind Jenkins, Lekh N. Dahal, Rui J. Nobre, Luís de Pereira de Almeida, Mark Trautwein, Paula M. Alves, Catarina Brito   +14 more
wiley   +1 more source

Engineering Approaches to Modify Immunomodulatory Functions of Mesenchymal Stromal Cells (MSCs): Tissue Regeneration and Clinical Application

Advanced Science, EarlyView.
Mesenchymal stromal cells (MSCs) show promise for treating immune‐related disorders through immunomodulation and tissue regeneration. This review gives a brief overview of current clinical approval of MSC therapies. It also discussed how bioengineering, including genetic modification, biomaterial delivery, extracellular vesicles, and iPSC‐derived MSCs,
Sichen Yang, Kejia Li, Ning Wang, Zhen Li, Zhiyong Zhang, Rocky S. Tuan, Yangzi Jiang   +6 more
wiley   +1 more source

Dynamics of systolic functional indexes of the heart and systolic interventricular interaction in patients with chronic heart failure of ischemic genesis depending on functional class

Patologìâ, 2012
The peculiarities of changes of systolic functional indexes of the right heart chambers and interventricular interaction depending on functional class of heart failure of ischemic genesis in 111 patients with chronic heart failure of I-IV functional ...
V.V. Syvolap, N.V. Tumanskaya
doaj   +1 more source

Cyclic Mechanical Loading of Cardiomyocytes via Pressure‐Driven Non‐Planar Membrane Deformation in a Bioreactor System

Advanced Science, EarlyView.
In this research article, Mansoor and coworkers present a novel device that applies controlled mechanical stimuli to cardiomyocytes using pressure‐driven membrane deformation. By exposing cells to physiologically and pathologically relevant loading conditions, the platform reproduces distinct structural, functional and molecular responses associated ...
Haris Mansoor, Gabrielle Juul, Jil Patel, Heran Pradhan, Gram Hepner, Jackson Jewell, Mark Bardin, Ryan Slusser, Abigail Glezer, Leda Klouda, Melikhan Tanyeri, Anita Saraf   +11 more
wiley   +1 more source

Establishing a mouse model of lung metastases using ultrasound-guided right heart ventricle injection. [PDF]

STAR Protoc, 2023
Labora A, Creech A, Lee H, Tabornal E, Radu C, Donahue T.   +5 more
europepmc   +1 more source