Results 1 to 10 of about 2,245,341 (387)

Proteomic and metabolomic analyses of the human adult myocardium reveal ventricle-specific regulation in end-stage cardiomyopathies [PDF]

Communications Biology
The left and right ventricles of the human heart are functionally and developmentally distinct such that genetic or acquired insults can cause dysfunction in one or both ventricles resulting in heart failure.
Benjamin Hunter, Mengbo Li, Benjamin L. Parker, Yen Chin Koay, Dylan J. Harney, Evangeline Pearson, Jacob Cao, Gavin T. Chen, Oneka Guneratne, Gordon K. Smyth, Mark Larance, John F. O’Sullivan, Sean Lal   +12 more
doaj   +4 more sources

Acclimation of Hairless Spontaneously Hypertensive Rat to Ambient Temperature Attenuates Hypertension-Induced Pro-Arrhythmic Downregulation of Cx43 in the Left Heart Ventricle of Males [PDF]

Biomolecules
Objectives: Due to poor treatment adherence and lifestyle-based interventions, chronic hypertension is a dominant risk factor predisposing individuals to heart failure and malignant arrhythmias.
Katarina Andelova, Matus Sykora, Veronika Farkasova, Tatiana Stankovicova, Barbara Szeiffova Bacova, Vladimir Knezl, Tamara Egan Benova, Michal Pravenec, Narcis Tribulova   +8 more
doaj   +2 more sources

The effect of sodium, calcium and metabolic inhibitors on calcium efflux from goldfish heart ventricles.

Journal of Physiology, 1978
1. 45Ca efflux and tissue Ca content were examined in goldfish ventricles under conditions known to affect cellular Ca movements. 2. EGTA or Ca‐EGTA was added to the washout solutions in sufficient concentration (10 mM) to avoid retardation of the ...
P Busselen, Emmy Van Kerkhove
openalex   +2 more sources

Parameter variations in personalized electrophysiological models of human heart ventricles. [PDF]

PLoS ONE, 2021
The objectives of this study were to evaluate the accuracy of personalized numerical simulations of the electrical activity in human ventricles by comparing simulated electrocardiograms (ECGs) with real patients' ECGs and analyzing the sensitivity of the
Konstantin Ushenin, Vitaly Kalinin, Sukaynat Gitinova, Oleg Sopov, Olga Solovyova   +4 more
doaj   +2 more sources

Numerical simulation of electrocardiograms for full cardiac cycles in healthy and pathological conditions [PDF]

arXiv, 2015
This work is dedicated to the simulation of full cycles of the electrical activity of the heart and the corresponding body surface potential. The model is based on a realistic torso and heart anatomy, including ventricles and atria. One of the specificities of our approach is to model the atria as a surface, which is the kind of data typically provided
Bayés de Luna, Bayés de Luna, Beinart, Bishop, Boulakia, Boulakia, Boulakia, Bourgault, Bueno-Orovio, Buist, Chapelle, Chapelle, Chatterjee, Cohen, Collin, Corrado, Courtemanche, Deng, Ennis, Geuzaine, Harrild, Ho, Ho, Hoekema, Hudsmith, Huiskamp, Huiskamp, Hurtadoa, Jiamsripong, Jiang, Johnson, Keller, Krishnamoorthi, Krueger, Krueger, Lines, Liu, Malmivuo, Martin, Martini, Matsuo, McGuire, Mitchell, Nash, Netter, Nielsen, Ormiston, Potse, Potse, Pullan, Rosner, Sachse, Sovilj, Streeter, Sundnes, Sundnes, Trudel, Wang, Wartak, Wei, Yan, Zwink   +61 more
arxiv   +7 more sources

The absence of dystrophin brain isoform expression in healthy human heart ventricles explains the pathogenesis of 5' X-linked dilated cardiomyopathy

BMC Medical Genetics, 2012
Background In X-linked dilated cardiomyopathy due to dystrophin mutations which abolish the expression of the M isoform (5'-XLDC), the skeletal muscle is spared through the up-regulation of the Brain (B) isoform, a compensatory mechanism that does not ...
Neri Marcella, Valli Emanuele, Alfano Giovanna, Bovolenta Matteo, Spitali Pietro, Rapezzi Claudio, Muntoni Francesco, Banfi Sandro, Perini Giovanni, Gualandi Francesca, Ferlini Alessandra   +10 more
doaj   +2 more sources

Electrolyte Content of Rat Heart Atria and Ventricles [PDF]

Circulation Research, 1960
Extracellular tissue spaces are compared using inulin, sucrose, chloride and sodium in hearts perfused with Ringer-Locke solution by Langendorff's method. Also chloride and sodium spaces are given for unperfused, fresh hearts.
J. A. Barclay, E. J. Hamley, HELGA HOUGHTON   +2 more
openalex   +2 more sources

Diastolic shape of the right ventricle of the heart [PDF]

The Anatomical Record, 1998
Knowledge of right ventricular (RV) shape is important to the understanding of RV mechanical function and for the improvement of clinically important RV volume estimation techniques. Refinements to the simplest conceptions of RV shape are presented statistically here, based on a quantitative analysis of three-dimensional magnetic resonance (MR) images ...
Peter J. Yim, Belinda Ha, José I. Ferreiro, G. William Henry, Craig Branch, Timothy A. Johnson, Carol L. Lucas   +6 more
openalex   +4 more sources

Heart Failure and Ventricular Dysfunction in Patients With Single or Systemic Right Ventricles [PDF]

Circulation, 2002
Background—Previous studies suggested a high incidence of congestive heart failure in patients with single and/or systemic right ventricles. The corresponding risk in an adult population is unknown.
Sanaz Piran, Gruschen Veldtman, Samuel C. Siu, Gary D. Webb, Peter P. Liu   +4 more
openalex   +2 more sources

A tissue-engineered scale model of the heart ventricle [PDF]

Nature Biomedical Engineering, 2018
Laboratory studies of the heart use cell and tissue cultures to dissect heart function yet rely on animal models to measure pressure and volume dynamics. Here, we report tissue-engineered scale models of the human left ventricle, made of nanofibrous scaffolds that promote native-like anisotropic myocardial tissue genesis and chamber-level contractile ...
L. Macqueen, L. Macqueen, S. Sheehy, S. Sheehy, Christophe O. Chantre, Christophe O. Chantre, J. Zimmerman, J. Zimmerman, F. Pasqualini, F. Pasqualini, Xujie Liu, Josue A. Goss, Josue A. Goss, Patrick H. Campbell, Patrick H. Campbell, Grant M. Gonzalez, Grant M. Gonzalez, Sung-Jin Park, Sung-Jin Park, A. Capulli, A. Capulli, John P Ferrier, John P Ferrier, T. F. Kosar, L. Mahadevan, William T. Pu, W. Pu, K. Parker, K. Parker   +28 more
semanticscholar   +4 more sources