Results 41 to 50 of about 2,557,215 (346)

Use of the Left Ventricular Internal Dimension at End-Diastole and the E-Point Septal Separation Ratio in the Prediction of the Left Ventricular Systolic Function in Patients with Midrange and Reduced Ejection Fractions: A Pilot Study

Journal of Tehran University Heart Center, 2019
Background: The aim of this study was to investigate the ability of a new index, namely the left ventricular internal dimension at end-diastole/mitral valve E-point septal separation (LVIDd/EPSS), to predict the left ventricular (LV) systolic function ...
Kahraman Cosansu, Harun Kilic, Ayca Turer Cabbar, Erdinc Hatipsoylu, Bilgehan Karadag, Ramazan Akdemir   +5 more
doaj   +1 more source

Functional modulation of the transient outward current Ito by KCNE beta-subunits and regional distribution in human non-failing and failing hearts

, 2006
Objectives: The function of Kv4.3 (KCND3) channels, which underlie the transient outward current I,, in human heart, can be modulated by several accessory subunits such as KChIP2 and KCNE1-KCNE5.
Cotella, D., Varró, András, Ravens, U., Wettwer, E., Radicke, S., Banse, U., Jost, Norbert, Graf, E., Tseng, G.   +8 more
core   +1 more source

White Matter Hyperintensity Burden and Short‐Interval Change Associated With Sleep Apnoea in the UK Biobank

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Background and Purpose White matter hyperintensities (WMH) are a core neuroimaging marker of cerebral small vessel disease (CSVD). Sleep apnoea (SA) is a recognized vascular risk factor, but its associations with regional WMH burden, short‐interval WMH change and cognitive performance in population‐based cohorts remain incompletely defined. We
Peng Cheng, Diego Z. Carvalho, Shahid Karim, Anwar Chahal, Virend K. Somers   +4 more
wiley   +1 more source

Cells of the adult human heart [PDF]

, 2020
Cardiovascular disease is the leading cause of death worldwide. Advanced insights into disease mechanisms and therapeutic strategies require deeper understanding of the healthy heart’s molecular processes.
DeLaughter, Daniel M, Krishnaa T. Mahbubani, Zhang, Hongbo, Viveiros, Anissa, Bayraktar, O., Bayraktar, O.A., Lindberg, E.L., Tuck, Liz, Tuck, L., Zhang, H., Michael Lee, Lindberg, Eric L, Sara Samari, Lee, M.l, Zhang, Hao, Noseda, Michela, Samari, Sara, Mahbubani, K.T., Eirini S. Fasouli, Joshua M. Gorham, Kourosh Saeb-Parsy, Seidman, Christine E, Heinig, M., Nadelmann, Emily R, Roberts, K., Lee, Michael, Masatoshi Kanda, Anissa Viveiros, Saeb-Parsy, K., Litviňuková, M., Samari, S., Teichmann, Sarah A, Heinig, Matthias, Mahbubani, Krishnaa T, Reichart, D., Daniel Reichart, Bayraktar, Omer Ali, Hubner, Norbert, Omer Ali Bayraktar, Krzysztof Polanski, J. G. Seidman, Kenny Roberts, Hubner, N., Eric L. Lindberg, Hao Zhang, Seidman, JG, McDonough, B., Catherine L. Worth, Joseph J. Boyle, Viveiros, A., Gorham, Joshua M, Emily R. Nadelmann, Boyle, Joseph J, Seidman, C.E., Wakimoto, H., Hiroko Wakimoto, Seidman, J.G., Hongbo Zhang, Patone, G., Maatz, Henrike, Roberts, Kenny, Maatz, H., Polanski, Krzysztof, Lee, M., Christine E. Seidman, Michela Noseda, Noseda, M., Gorham, J.M., Monika Litviňuková, Sarah A. Teichmann, Giannino Patone, Patone, Giannino, DeLaughter, D.M., Matthias Heinig, Boyle, J.J., Teichmann, S.A., Worth, Catherine L, Kanda, Masatoshi, Polanski, K., Norbert Hubner, Fasouli, Eirini S, Daniel M. DeLaughter, Reichart, Daniel, Talavera-López, C., Worth, C.L., Carlos Talavera-López, McDonough, Barbara, Henrike Maatz, Wakimoto, Hiroko, Litvinukova, Monika, Saeb-Parsy, Kourosh, Liz Tuck, Barbara McDonough, Talavera-Lopez, Carlos, Kanda, M., Fasouli, E.S., Oudit, Gavin Y, Nadelmann, E.R., Gavin Y. Oudit, Oudit, G.Y.   +99 more
core   +1 more source

Early Clinical, Imaging, and Pathological Characteristics of SRPK3/TTN‐Digenic Myopathy

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective SRPK3/TTN‐digenic myopathy was recently established as a skeletal muscle myopathy caused by digenic inheritance. This study characterizes the early clinical presentation of SRPK3/TTN‐digenic myopathy in one previously reported and seven newly identified pediatric patients.
Rotem Orbach, Sandra Donkervoort, Carola Hedberg‐Oldfors, Giovanni Baranello, Dimah Saade, Precilla D'Souza, Ruchee Patel, Eva Michael, A. Reghan Foley, Diana Bharucha‐Goebel, S. Jin Haugland, Meghan McAnally, Omer Abdul Hamid, Katherine Chao, Ellen F. Macnamara, Alan H. Beggs, Anna Sarkozy, Juliane Mueller, Steven A. Moore, Richard S. Finkel, Cynthia J. Tifft, Francesco Muntoni, Anders Oldfors, Carsten G. Bönnemann   +23 more
wiley   +1 more source

White Matter Microstructural Abnormalities in Neonatal Onset Genetic Epilepsy

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Recent evidence indicates that epilepsy is associated with abnormal white matter. If seizures alter white matter, then the impact upon network function, epileptogenesis, and cognition could be pronounced in neonates undergoing rapid developmental myelination. Neonates with epilepsy due to nonstructural genetic causes provide a unique
Amanda G. Sandoval Karamian, Tianjia Zhu, Hao Huang, Shavonne L. Massey, Mark P. Fitzgerald, Darshana Parikh, Arastoo Vossough, Ingo Helbig, Nicholas S. Abend   +8 more
wiley   +1 more source

Ventricle-specific epicardial pressures as a means to optimize direct cardiac compression for circulatory support: A pilot study.

PLoS ONE, 2019
Direct cardiac compression (DCC) holds enormous potential as a safe and effective means to treat heart failure patients who require long-term, or even permanent, biventricular support.
Jooli Han, Matthew Kubala, Edgar Aranda-Michel, Dennis R Trumble   +3 more
doaj   +1 more source

6-Nitrodopamine Is the Most Potent Endogenous Positive Inotropic Agent in the Isolated Rat Heart

Life, 2023
Background: 6-nitrodopamine released from rat isolated atria exerts positive chronotropic action, being more potent than noradrenaline, adrenaline, and dopamine.
José Britto-Júnior, Lincoln Rangel Medeiros-Teixeira, Antonio Tiago Lima, Letícia Costa Dassow, Rodrigo Álvaro Brandão Lopes-Martins, Rafael Campos, Manoel Odorico Moraes, Maria Elisabete A. Moraes, Edson Antunes, Gilberto De Nucci   +9 more
doaj   +1 more source

Isolated Biventricular Noncompaction in an adult with severe pulmonary hypertension : an association reviewed. [PDF]

, 2012
Biventricular noncompaction is a recently recognized rare form of cardiomyopathy. It is characterized by altered structure of myocardial wall as a result of intrauterine arrest of compaction of the myocardial fibers in absence of coexisting congenital
Awasthy, Neeraj, Tomar, Munesh, Radhakrishnan, Sitaraman   +2 more
core  

Temporal Trends and Short‐ and Long‐Term Mortality of People With Acute Myocardial Infarction and Rheumatoid Arthritis: A Nationwide Cohort Study

Arthritis Care &Research, EarlyView.
Objective We investigated whether a diagnosis of rheumatoid arthritis (RA) affects the quality of inpatient acute myocardial infarction (AMI) care and long‐term mortality post‐AMI. Methods We analyzed data from 784,091 adults, 6,047 with a diagnosis of RA, from England and Wales hospitalized with AMI between 2005 and 2019 from the Myocardial Ischaemia ...
Megan Butler, Nicholas Weight, Muhammad Rashid, Rodrigo Bagur, Purvi Parwani, Samantha Hider, Edward Roddy, Robert Butler, Mamas A. Mamas   +8 more
wiley   +1 more source