Results 11 to 20 of about 60,448 (331)

The significance of heartburn [PDF]

QJM, 2000
Heartburn is a common symptom which 10% of the general population experience on a weekly basis.1,,2 Along with other symptoms of dyspepsia, it accounts for 1 in 20 GP consultations, with prescriptions for proton‐pump inhibitors consuming more than 6% of the primary‐care drugs budget.3,,4 Recent studies into the long‐term effects of reflux symptoms have
Brian T. Johnston
openaire   +4 more sources

Hiatus hernia and heartburn [PDF]

Gut, 1969
The symptoms in a group of 80 patients with a pure sliding hiatus hernia were investigated using the pyloric regulation test (Capper, Airth, and Kilby, 1966). It was found that there was a high correlation between the symptoms of heartburn and the reflux of duodenal barium into the stomach.
M. J. Gibson, W.M. Capper, E. W. Gillison, I. Bradford, G. R. Airth   +4 more
openaire   +4 more sources

Effects of Tegoprazan Versus Esomeprazole on Nighttime Heartburn and Sleep Quality in Gastroesophageal Reflux Disease: A Multicenter Double-blind Randomized Controlled Trial

Journal of Neurogastroenterology and Motility, 2022
Background/Aims Patients with gastroesophageal reflux disease (GERD) frequently experience nighttime heartburn and sleep disturbance. Tegoprazan is a new potassium-competitive acid blocker that can rapidly block acid secretion.
J. Kim, S. Seo, S. Kang, Sang Kil Lee, A. R. Kim, Hyun Wook Park, Bongtae Kim, G. Song   +7 more
semanticscholar   +1 more source

True heartburn. [PDF]

BMJ, 1967
A D Roy
openaire   +4 more sources

Heartburn Sensation in Non-Erosive Reflux Disease: Pattern of Superficial Sensory Nerves Expressing TRPV1 and Epithelial Cells Expressing ASIC3 Receptors.

American Journal of Physiology - Gastrointestinal and Liver Physiology, 2021
The underlying causes of heartburn, characteristic symptom of gastro-esophageal reflux disease(GERD), remain incompletely understood. Superficial afferent innervation of the esophageal mucosa in nonerosive reflux disease(NERD) may drive nociceptive ...
A. Ustaoglu, Akinari Sawada, Chung Lee, W. Lei, Chien‐Lin Chen, R. Hackett, D. Sifrim, M. Peiris, P. Woodland   +8 more
semanticscholar   +1 more source

Sleep disruption due to nocturnal heartburn: a review of the evidence and clinical implications

Exploration of Medicine, 2023
Nocturnal heartburn (NHB) is a symptom that affects up to 25% of the general population and has been shown to cause sleep disruption that adversely affects quality of life and psychomotor performance.
David A. Johnson, Amisha M. Parikh-Das, Evren Atillasoy, Hayk Davtyan, Leslie Shur, Andrea S. Blevins-Primeau, Nathaniel F. Watson   +6 more
doaj   +1 more source

Phenotypes of gastroesophageal reflux disease: classification, pathogenesis and diagnostic criteria: A review

Consilium Medicum, 2022
The literature review focuses on the current understanding of visceral hypersensitivity mechanisms in the esophagus. Mechanisms of peripheral and central sensitization and their relation to heartburn symptoms are covered in detail.
Igor V. Maev, Elena V. Barkalova, Mariia A. Ovsepian, Dmitry N. Andreev   +3 more
doaj   +1 more source

Heartburn in children and adolescents in the presence of functional dyspepsia and/or irritable bowel syndrome correlates with the presence of sleep disturbances, anxiety, and depression

Medicine, 2021
The aim of this study was to assess the relationship of heartburn in pediatric patients with functional dyspepsia (FD) and irritable bowel syndrome (IBS) with gastrointestinal symptoms, sleep disturbances, and psychologic distress.
J. Colombo, Amanda D. Deacy, J. Schurman, C. Friesen   +3 more
semanticscholar   +1 more source

First‐Line Osimertinib in Patients with EGFR‐Mutant Advanced Non‐Small Cell Lung Cancer: Outcome and Safety in the Real World: FLOWER Study

The Oncologist, EarlyView., 2021
Abstract Lessons Learned Osimertinib has confirmed effectiveness in this real‐world population of patients with EGFR‐mutant advanced non‐small cell lung cancer. Thromboembolic events occur more frequently than previously reported, suggesting a thrombotic diathesis that requires further investigation. Patients with at least three metastatic sites, brain
Martina Lorenzi, Alessandra Ferro, Fabiana Cecere, Daniela Scattolin, Alessandro Del Conte, Alessandro Follador, Sara Pilotto, Valentina Polo, Mariacarmela Santarpia, Rita Chiari, Alberto Pavan, Alessandro Dal Maso, Valentina Da Ros, Giada Targato, Sabrina Vari, Stefano Indraccolo, Fiorella Calabrese, Stefano Frega, Laura Bonanno, Pier Franco Conte, Valentina Guarneri, Giulia Pasello   +21 more
wiley   +1 more source

The importance of functional diagnostics in determining the cause of antisecretary therapy inefficiency in a patient with heartburn: clinical observation

Медицинский совет, 2021
One of the main symptoms of gastroesophageal reflux disease is heartburn, for the relief of which proton pump inhibitors are traditionally prescribed. However, there are frequent cases of heartburn, refractory to antisecretory therapy, when there is no ...
E. V. Barkalova, D. N. Andreev, M. A. Ovsepian   +2 more
doaj   +1 more source