An epithelial GPR35 isoform supports tumor‐associated transcriptional and metabolic phenotypes
GPR35 generates two functionally distinct isoforms with previously unresolved roles. GPR35‐short mediates immune‐cell chemotaxis, while GPR35‐long is enriched in colorectal cancer epithelium, where it supports increased metabolism, proliferation, and tumor‐associated transcriptional programs.
Jørgen D. Rønneberg +14 more
wiley +1 more source
Emerging experimental and computational methods for studying redox‐regulated structural transitions
Redox reactions can reshape proteins and alter how they behave in cells, with important consequences for health and disease. This review explores emerging experimental and computational approaches for discovering these redox‐sensitive protein switches, revealing their structural effects, and predicting their behavior, opening new opportunities to ...
Tasneem Rass +2 more
wiley +1 more source
Translophagy—A potential link between autophagy impairment and translational errors
Neurodegenerative diseases are characterised by the accumulation of abnormal proteins and protein aggregates, but their origin often remains unknown. We propose that selective autophagy removes damaged protein‐making machinery, preventing errors during protein synthesis.
Mykola V. Korolchuk +11 more
wiley +1 more source
The laminar and turbulent regimes of a boundary layer on a flat plate are often represented with separate correlations under the assumption of a distinct “transition Reynolds number.” Average heat coefficients are then calculated by integrating across ...
Lienhard, John H, Lienhard, John H.
core +1 more source
Refrigerant forced-convection condensation inside horizontal tubes [PDF]
High vapor velocity condensation inside a tube was studied theoretically. The heat transfer coefficients were calculated by the momentum and heat transfer analogy.
Bae, S. +8 more
core +1 more source
Encapsulins are protein nanocompartments that play an important role in iron storage. In the Myxococcus xanthus encapsulin system, two cargo proteins called EncB and EncC contribute to iron mineralization. Here, we show that EncB and EncC generate iron‐containing minerals with distinct chemical compositions, suggesting that the composition of stored ...
Harry B. McDowell +2 more
wiley +1 more source
Tables for solution of the heat-conduction equation with a time-dependent heating rate [PDF]
Tables are presented for the solution of the transient onedimensional heat flow in a solid body of constant material properties with the heating rate at one boundary dependent on time. These tables allow convenient and rapid estimation of the temperature
Bergles A. E.
core
The design of mini/micro heat exchangers: A world of opportunities and constraints [PDF]
Micro heat exchangers and heat sinks broadened their use in many technological fields during the last two decades. The reduction of the dimensions of the channels allows to obtain ultra-compact heat exchangers characterized by higher surface-to-volume ...
Gian Luca Morini +5 more
core +1 more source
The Shewanella oneidensis Fic enzyme SoFic targets the switch‐I region of EF‐Tu for AMPylation
Fic enzymes mediate diverse post‐translational modifications across all domains of life, including AMPylation. Prokaryotic EF‐Tu can be AMPylated and deAMPylated by the conserved Fic enzyme SoFic. Structural and biochemical approaches were used to characterize the effect of AMPylation on EF‐Tu, SoFic's enzymatic activities, and the enzyme‐target ...
Svenja Runge +6 more
wiley +1 more source
Investigation of heat transfer augmentation through use of internally finned and roughened tubes : final summary report [PDF]
This report summarizes a three-year program concerned with obtaining basic design information for tubes having a random roughness on the inside wall (RID) and tubing having continuous internal fins (Forge Fin).
Brown, G. S. +4 more
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