Results 71 to 80 of about 3,013,413 (256)

High-Temperature Heat Pumps : Task 1 – Technologies. Annex 58 about High-Temperature Heat Pump

open access: yes, 2023
Industries are using a considerable share of their final energy consumption on process heating, which is often based on fossil fuels and accordingly accounting for a large share of their greenhouse gas emissions.
Zühlsdorf, Benjamin
core   +2 more sources

A novel quinazolinone insulin receptor inhibitor and its synergy with an EGFR inhibitor in glucose‐driven glioblastoma

open access: yesMolecular Oncology, EarlyView.
The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka   +9 more
wiley   +1 more source

A Robust Neural Network Algorithm For Automotive Air Conditioning Fault Detection

open access: yesInternational Journal of Automotive Engineering, 2020
Accurate and incipient fault detection of air conditioning systems is highly demanded in a car to prevent energy waste and high maintenance cost. However, most fault detection techniques require experiences of drivers which are usually unavailable.
Dinh Anh Tuan Tran   +2 more
doaj   +1 more source

Oncogenic DMTF1β promotes cancer cell motility by regulating autophagy through ULK1 stabilization

open access: yesMolecular Oncology, EarlyView.
In the current study, we demonstrate that the oncogene DMTF1β regulates ULK1 stability by reducing its proteasomal degradation in cancer cells. This stabilization enables ULK1 to induce autophagy, which in turn facilitates cancer cell migration. Consequently, reduced DMTF1β levels lead to decreased autophagy and impaired cancer cell migration.
Jun Xu   +13 more
wiley   +1 more source

Sorption and desorption isotherms of celery roots [PDF]

open access: yesBIO Web of Conferences
An experimental study for determining the wet basis equilibrium moisture content in celery root (Apium graveolens) was conducted. Empirical equations describing the isotherms of sorption and desorption of the product at a temperature of 20°C were ...
Georgieva Mariya   +3 more
doaj   +1 more source

PAK1 activation drives divergent resistance mechanisms to aromatase inhibition and tamoxifen in a luminal: A breast cancer model

open access: yesMolecular Oncology, EarlyView.
Breast cancer remains a major cause of cancer death in women, frequently developing endocrine therapy resistance. This study demonstrates that upregulated p21‐activated kinase 1 (PAK1) activity drives resistance to tamoxifen and long‐term estrogen deprivation in ER+ breast cancer models.
Luisa Schwarzmüller   +10 more
wiley   +1 more source

Noise reduction in heat pumps

open access: yes, 2001
If not designed and installed properly in a suitable location, heat pumps can produce noise at nuisance levels for adjacent residents. Various (national and international) systems and guidelines used for measuring, predicting and regulating noise levels ...
Eggenschwiler, Kurt (author)   +1 more
core   +1 more source

Inhibition of cyclin‐dependent kinases 12/13 using CT7439 as a treatment for colorectal cancer with CDK12 upregulation

open access: yesMolecular Oncology, EarlyView.
The proposed mechanism of action for the CDK12/13 inhibitor and cyclin K degrader, CT7439. CDK12/13 inhibition interrupts transcription elongation, leading to increased DNA damage that results in cell death. This agent is a potentially novel treatment option for patients with colorectal cancer. Created in BioRender. Cyclin‐dependent kinase (CDK) 12 and
Wylie K. Watlington   +10 more
wiley   +1 more source

Epigenetic silencing of the liver‐specific lncRNA LUNAR promotes liver cancer progression via NOTCH activation

open access: yesMolecular Oncology, EarlyView.
LUNAR is a liver‐specific long noncoding RNA (lncRNA) that is highly expressed in normal liver but becomes epigenetically silenced in hepatocellular carcinoma through promoter hypermethylation. Loss of LUNAR is associated with NOTCH activation, epithelial–mesenchymal transition, and metastasis, whereas restoring LUNAR restrains metastatic progression ...
Se Ha Jang   +9 more
wiley   +1 more source

Parallel Triangular Channel System for Latent Heat Thermal Energy Storages

open access: yes, 2018
A computational investigation on thermal energy storage system using Phase Change Material (PCM) is accomplished. The system is a honeycomb structure made of parallel triangular channels and half of them are filled with PCM and the others are passed ...
A. ANDREOZZI   +7 more
core   +1 more source

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