Results 31 to 40 of about 126,161 (267)

Numerical investigation on flow and heat transfer characteristics of supercritical methane–ethane mixture in a straight channel

Science and Technology for Energy Transition, 2022
Printed Circuit Heat Exchanger (PCHE) is considered as a promising heat exchanger for offshore Liquefied Natural Gas (LNG) production due to its compactness and high efficiency.
Wang Yue, Li Yue, Chen Jie, Li Qian, Cai Weihua   +4 more
doaj   +1 more source

An epithelial GPR35 isoform supports tumor‐associated transcriptional and metabolic phenotypes

FEBS Letters, EarlyView.
GPR35 generates two functionally distinct isoforms with previously unresolved roles. GPR35‐short mediates immune‐cell chemotaxis, while GPR35‐long is enriched in colorectal cancer epithelium, where it supports increased metabolism, proliferation, and tumor‐associated transcriptional programs.
Jørgen D. Rønneberg, Martine Hjeltnes, Josephine Krieger, Joshua E. Elias, Maria Stensland, Kristian Holm, Xiaojun Jiang, Chuki Khangsar, Tuula A. Nyman, Arthur Kaser, Johannes R. Hov, Tom H. Karlsen, Nicole C. Kaneider, Frode L. Jahnsen, Georg Schneditz   +14 more
wiley   +1 more source

Study on Boiling Heat Transfer Characteristics of R290 in Horizontal Micro-tubes

Zhileng xuebao, 2020
In this study the boiling heat transfer characteristics of R290 in a 1, 2, and 4 mm horizontal micro-tube were investigated experimentally. The effects of mass flow rate [50-600 kg/(m2?s)], quality (0-1), and heat flux (5-20 kW/m2) on the boiling heat ...
Wang Haoyu, Liu Jianhua, Zhang Liang, Yu Xiaoxiao   +3 more
doaj  

Engineered extracellular vesicles enriched with the miR‐214/199a cluster enhance the efficacy of chemotherapy in ovarian cancer

Molecular Oncology, EarlyView.
Loss of the miR‐214/199a cluster is associated with recurrence in ovarian cancer. Engineered small extracellular vesicles (m214‐sEVs) elevate miR‐214‐3p/miR‐199a‐5p in tumor cells, suppress β‐catenin, TLR4, and YKT6 signaling, reprogram tumor‐derived sEV cargo, reduce chemoresistance and migration, and enhance carboplatin efficacy and survival in ...
Weida Wang, Ayesha Alvero, Yi Qin, Mingjin Wang, Alexandra Fox, Yanfeng Li, Michael Millman, Amy Kemper, Gil Mor, Xian Shuang Liu, Michael Chopp, Zheng Gang Zhang, Yi Zhang   +12 more
wiley   +1 more source

IMPDH inhibition enhances cytarabine efficacy in SAMHD1‐expressing leukaemia cells via guanine nucleotide depletion

Molecular Oncology, EarlyView.
Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla, Christopher Dirks, Caroline Eiden, Sonja K. Fesenmayer, Femke M. Hormann, Yolande Klootsema, Ingrid Lilienthal, Si Min Zhang, Nikolas Herold, Sean G. Rudd   +9 more
wiley   +1 more source

Activation Energy Impact on Flow of AA7072-AA7075/Water-Based Hybrid Nanofluid through a Cone, Wedge and Plate

Micromachines, 2022
The present research investigates the effect of a heat source/sink on nanofluid flow through a cone, wedge, and plate when using a suspension of aluminium alloys (AA7072 and AA7075) as nanoparticles in base fluid water.
Maaliger B. Rekha, Ioannis E. Sarris, Javali K. Madhukesh, Kondethimmanahalli R. Raghunatha, Ballajja C. Prasannakumara   +4 more
doaj   +1 more source

A novel quinazolinone insulin receptor inhibitor and its synergy with an EGFR inhibitor in glucose‐driven glioblastoma

Molecular Oncology, EarlyView.
The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka, Wioleta Cieślik, Wojciech Płaziński, Katarzyna Stępnik, Anna Boguszewska‐Czubara, Elżbieta Kot, Robert Musioł, Mateusz Jasica, Anna Mrozek‐Wilczkiewicz, Katarzyna Malarz   +9 more
wiley   +1 more source

Design and Experimental Study on CO2 Water-cooled Tube-in-tube Gas Cooler

Zhileng xuebao, 2016
A water-cooled tube-in-tube gas cooler was designed in this paper, and experimental researches on it were conducted. A triple tube is equipped in the gas cooler with CO2 in the inner tubes and water between inner and outer tubes.
L, Jing, Ma Yiping, Cao Ke, Shi Dongdong, Gao Qiang, Hu Tete   +6 more
doaj  

Oncogenic DMTF1β promotes cancer cell motility by regulating autophagy through ULK1 stabilization

Molecular Oncology, EarlyView.
In the current study, we demonstrate that the oncogene DMTF1β regulates ULK1 stability by reducing its proteasomal degradation in cancer cells. This stabilization enables ULK1 to induce autophagy, which in turn facilitates cancer cell migration. Consequently, reduced DMTF1β levels lead to decreased autophagy and impaired cancer cell migration.
Jun Xu, Nicolas J. Niklaus, Anna M. Schläfli, Igor Tokarchuk, Magali Humbert, Federico La Manna, Bich Vu, David Maul, Ramin Radpour, Marianna Kruithof‐de Julio, Inti Zlobec, Jörn Dengjel, Bruce E. Torbett, Mario P. Tschan   +13 more
wiley   +1 more source

low Boiling Heat Transfer Characteristics of R290 in 5mm Small-diameter Tubes

Zhileng xuebao, 2019
The characteristics of heat transfer for R290 flow boiling in 5 mm small diameter tubes were investigated experimentally with a focus on the effects of heat flux, mass flow rate, and saturation temperature on the surface coefficient of boiling heat ...
He Kuan, Liu Jianhua, Yu Xiaoxiao
doaj