Results 91 to 100 of about 1,047,921 (298)

Large‐scale bidirectional arrayed genetic screens identify OXR1 and EMC4 as modifiers of αSynuclein aggregation

open access: yesFEBS Open Bio, EarlyView.
Activation of the mitochondrial protein OXR1 increases pSyn129 αSynuclein aggregation by lowering ATP levels and altering mitochondrial membrane potential, particularly in response to MSA‐derived fibrils. In contrast, ablation of the ER protein EMC4 enhances autophagic flux and lysosomal clearance, broadly reducing α‐synuclein aggregates.
Sandesh Neupane   +11 more
wiley   +1 more source

Mass spectrometry based identification of AMP‐O‐Tris generated by Thermococcus onnurineus Cas10

open access: yesFEBS Open Bio, EarlyView.
Isolated Thermococcus onnurineus Cas10 generates the noncanonical ATP‐derived product AMP‐O‐Tris while in Tris‐containing buffer as identified via mass spectrometry, revealing relaxed nucleophile selectivity under isolated conditions. These findings suggest that multiprotein Csm complex assembly restricts Cas10 reactivity toward canonical cyclic ...
Su‐Jin Lee   +6 more
wiley   +1 more source

Pharmacological inhibition of the PERK pathway modulates hepatocellular carcinoma growth and immune signaling

open access: yesFEBS Open Bio, EarlyView.
Pharmacological inhibition of PERK in a DEN‐induced mouse model of liver cancer does not reduce tumor burden but alters cellular stress signaling. Despite blocking PERK activity, downstream stress responses, including CHOP expression, remain active, suggesting compensatory mechanisms within the unfolded protein response that may influence tumor ...
Ada Lerma‐Clavero   +5 more
wiley   +1 more source

A Study of Evaporation Heat Transfer Coefficient Correlations at Low Heat and Mass Fluxes for Pure Refrigerants and Refrigerant Mixtures [PDF]

open access: yes, 1993
An average R12 refrigerant correlation has been developed for the mass flux range of 25-100 kg/m2-s and the heat flux range of 2-10 kW/m2. Refrigerant mixtures of 80% R22/lO% R141b and 65% R22/35% R123 have also been tested over asjrniJar range of ...
Newell, T.A.   +2 more
core  

Cyclic azapeptide CD36 ligand attenuates cardiac injury and reduces long‐chain fatty acid accumulation after myocardial ischemia–reperfusion in mice

open access: yesFEBS Open Bio, EarlyView.
In a murine model of myocardial ischemia and reperfusion (MI/R), the CD36 azapeptide ligand MPE‐298 reduces cardiac injury and transiently lowers left ventricular long‐chain fatty acids (LCFAs) accumulation 3 h after reperfusion, accompanied by a decrease of oxidative stress and inflammation‐associated genes' expression in the heart and adipose tissue.
Jade Gauvin   +12 more
wiley   +1 more source

NASTRAN solutions of problems described by simultaneous parabolic differential equations [PDF]

open access: yes, 1975
NASTRAN solution techniques are shown for a numerical analysis of a class of coupled vector flow processes described by simultaneous parabolic differential equations.
Mason, J. B., Walston, W. H., Jr.
core   +1 more source

Feasibility and Tolerability of Performing Portable MRI for Neurological Disorders in an Outpatient Neurology Clinic: A Prospective Cohort

open access: yesAnnals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Background Accessing brain magnetic resonance imaging (MRI) can be challenging, especially for underserved patients, which may lead to disparities in neurological diagnosis. Method This mixed‐methods study enrolled adults with one of four neurological disorders: mild cognitive impairment or dementia of the Alzheimer type, multiple sclerosis ...
Maya L. Mastick   +19 more
wiley   +1 more source

ANALYSIS OF POTENTIAL DIRECTIONS OF INDUSTRIAL PROCESSING OF FERROUS METALS CHIPS IN THE REPUBLIC OF BELARUS

open access: yesЛитьë и металлургия, 2006
The forecast of formation of the ferrous metals chips in the Republic of Belarus is carried out.
V. I. Timoshpolski   +3 more
doaj  

WORKING PROCESS OF INTERNAL COMBUSTION ENGINE RUNNING ON ENRICHED HYDROGEN GASOLINE-AIR MIXTURE

open access: yesВесці Нацыянальнай акадэміі навук Беларусі: Серыя фізіка-тэхнічных навук, 2018
The effect of hydrogen additives on the working process of a piston-type gasoline engine is studied. The indicator diagram has been built, and the operation of the piston engine on gasoline-air mixtures enriched with hydrogen in the amount of 0…20 % of ...
M. S. Assad   +2 more
doaj   +1 more source

Analogy Between Mass and Heat Transfer with Turbulent Flow [PDF]

open access: yes
An analysis of combined heat and mass transfer from a flat plate has been made in terms of Prandtl t s simplified physical concept of the turbulent boundary layer.
Callaghan, Edmund E.
core   +1 more source

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