Results 61 to 70 of about 471,509 (261)

combined heating systems of premises for breeding of young pigs and poultry [PDF]

open access: yesFME Transactions, 2018
The use of traditional air heating systems in conjunction with supply ventilation for breeding of young animals in industrial conditions is not sufficiently effective.
Spodyniuk Nadiia   +2 more
doaj  

Oncogenic DMTF1β promotes cancer cell motility by regulating autophagy through ULK1 stabilization

open access: yesMolecular Oncology, EarlyView.
In the current study, we demonstrate that the oncogene DMTF1β regulates ULK1 stability by reducing its proteasomal degradation in cancer cells. This stabilization enables ULK1 to induce autophagy, which in turn facilitates cancer cell migration. Consequently, reduced DMTF1β levels lead to decreased autophagy and impaired cancer cell migration.
Jun Xu   +13 more
wiley   +1 more source

Liquid biopsy‐based diagnostic evaluation of hypermethylated CpG sites for ovarian cancer diagnosis

open access: yesMolecular Oncology, EarlyView.
This schematic outlines the workflow from biomarker identification to duplex MethyLight assay validation for epithelial ovarian cancer diagnosis using cfDNA‐based liquid biopsy. Initial screening of hypermethylated CpG candidates (cg02957270, cg10061138 cg00480298, COL2A1) was performed in tissue using ARMS‐PCR, COBRA, qPCR and image analysis. Selected
Deepa Bisht   +3 more
wiley   +1 more source

IMPROVEMENT OF ENGINE INDICATORS BY SUPPLYING LIQUID FUEL INTO THE INLET MANIFOLD [PDF]

open access: yesAvtomobilʹnyj Transport (Harʹkov), 2017
The results of the computational study of realizing the process of filling the four-stroke piston internal combustion engine 4 GCh 7.5/7.35 by feeding different types of fuel into the intake pipe in the liquid form are given.
F. Abramchuk, A. Kuzmenko, M. Boychuk
doaj  

Inhibition of cyclin‐dependent kinases 12/13 using CT7439 as a treatment for colorectal cancer with CDK12 upregulation

open access: yesMolecular Oncology, EarlyView.
The proposed mechanism of action for the CDK12/13 inhibitor and cyclin K degrader, CT7439. CDK12/13 inhibition interrupts transcription elongation, leading to increased DNA damage that results in cell death. This agent is a potentially novel treatment option for patients with colorectal cancer. Created in BioRender. Cyclin‐dependent kinase (CDK) 12 and
Wylie K. Watlington   +10 more
wiley   +1 more source

Influence of the Hot-Top Thermal Regime on the Severity and Extent of Macrosegregation in Large-Size Steel Ingots

open access: yesJournal of Manufacturing and Materials Processing
The influence of hot-top designs with different heat capacities on the distribution of positive and negative macrosegregation was investigated on a 12 metric tonne (MT) cast ingot made using Cr-Mo low-alloy steel.
Neda Ghodrati   +3 more
doaj   +1 more source

Thermodynamic Properties of κ-(BEDT-TTF)2X Salts: Electron Correlations and Superconductivity

open access: yesCrystals, 2012
Heat capacity measurements of κ-(BEDT-TTF)2X (BEDT-TTF: Bis(ethylendithio) tetrathiafulvalene, X: counteranions) which are classified as two-dimensional (2D) dimer-Mott system are reported.
Yasuhiro Nakazawa, Satoshi Yamashita
doaj   +1 more source

ZW4864‐mediated inhibition of the β‐catenin/BCL9/BCL9L complex reveals therapeutic potential in bladder cancer

open access: yesMolecular Oncology, EarlyView.
BCL9 and BCL9L drive bladder cancer progression by enhancing β‐catenin signaling, promoting proliferation, migration, invasion, and organoid growth. Genetic depletion of BCL9(L) suppresses malignant phenotypes, while pharmacological disruption of the β‐catenin/BCL9(L) complex with ZW4864 inhibits canonical Wnt signaling and tumor‐associated cellular ...
Roland Kotolloshi   +11 more
wiley   +1 more source

Thermodynamics of anisotropic triangular magnets with ferro- and antiferromagnetic exchange

open access: yesNew Journal of Physics, 2015
We investigate thermodynamic properties like specific heat c _V and susceptibility χ in anisotropic J _1 – J _2 triangular quantum spin systems ( $S=1/2$ ).
Burkhard Schmidt, Peter Thalmeier
doaj   +1 more source

A light‐triggered Time‐Resolved X‐ray Solution Scattering (TR‐XSS) workflow with application to protein conformational dynamics

open access: yesFEBS Open Bio, EarlyView.
Time‐resolved X‐ray solution scattering captures how proteins change shape in real time under near‐native conditions. This article presents a practical workflow for light‐triggered TR‐XSS experiments, from data collection to structural refinement. Using a calcium‐transporting membrane protein as an example, the approach can be broadly applied to study ...
Fatemeh Sabzian‐Molaei   +3 more
wiley   +1 more source

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