Results 81 to 90 of about 1,658,583 (289)

E2A selectively regulates TGF‐β–induced apoptosis in KRAS‐mutant non‐small cell lung cancer

Molecular Oncology, EarlyView.
Ability to induce apoptosis by TGF‐β is frequently lost in advanced lung adenocarcinoma despite intact TGF‐β signaling. We identify E2A as a mutant KRAS–dependent mediator of resistance to TGF‐β–induced apoptosis. TGF‐β induces E2A via SMAD3 in mutant KRAS cells, and E2A silencing restores apoptosis and enhances radiation response in cell lines ...
Sergei Chuikov, Shiva Krishna Katkam, Zhefan Wang, Venkateshwar G. Keshamouni   +3 more
wiley   +1 more source

Complex itinerant ferromagnetism in noncentrosymmetric Cr11Ge19

, 2012
The noncentrosymmetric ferromagnet Cr11Ge19 has been investigated by electrical transport, AC and DC magnetization, heat capacity, x-ray diffraction, resonant ultrasound spectroscopy, and first principles electronic structure calculations.
A. N. Bogdanov, A. N. Bogdanov, B. C. Sales, D. Mandrus, D. S. Parker, E. Schreiber, J.-Q. Yan, M. A. McGuire, M. Koehler, N. J. Ghimire, P. Blaha, P. Mohn, R. M. Latture, V. Keppens   +13 more
core   +1 more source

Proteasome inhibitor, ixazomib prevents topoisomerase‐I degradation and reverses irinotecan resistance in colorectal cancer

Molecular Oncology, EarlyView.
Ixazomib inhibits proteasome‐mediated degradation of topoisomerase I induced by irinotecan, thereby restoring drug sensitivity and promoting tumor cell death in colorectal cancer. Irinotecan, a topoisomerase I (topoI) inhibitor, is widely used for colorectal cancer, but resistance remains a major clinical challenge.
Yuho Ebata, Koji Ando, Hirofumi Hasuda, Koshi Mimori, Elizabeth C. Unan, Siddhartha Pulukuri, Aahana Tiku, Allison Berger, Eiji Oki, Ajit Bharti, Tomoharu Yoshizumi   +10 more
wiley   +1 more source

IMPROVEMENT OF ENGINE INDICATORS BY SUPPLYING LIQUID FUEL INTO THE INLET MANIFOLD [PDF]

Avtomobilʹnyj Transport (Harʹkov), 2017
The results of the computational study of realizing the process of filling the four-stroke piston internal combustion engine 4 GCh 7.5/7.35 by feeding different types of fuel into the intake pipe in the liquid form are given.
F. Abramchuk, A. Kuzmenko, M. Boychuk
doaj  

Heat-capacity anomalies at $T_{sc}$ and $T^{*}$ in the ferromagnetic superconductor UGe$_2$

, 2004
The heat-capacity and magnetization measurements under high pressure have been carried out in a ferromagnetic superconductor UGe$_2$. Both measurements were done using a same pressure cell in order to obtain both data for one pressure.
A. Huxley, A.B. Shick, A.D. Huxley, C. Pfleiderer, D. Fay, G. Motoyama, G. Oomi, H. Yamagami, I.A. Fomin, K. Amaya, K. Ishida, K. Machida, K.G. Sandeman, M. Sigrist, M. Tachiki, N. Tateiwa, N. Tateiwa, N. Tateiwa, R. Roussev, R. Settai, R. Settai, S. Nishizaki, S. Schmitt-Rink, S. Watanabe, S.S. Saxena, T. C. Kobayashi, T. Terashima, T. Terashima, T.R. Kirkpatrick, Y. Haga, Y. Haga, Y. Ushida, Y. Ōnuki, Y. Ōnuki, Z.Q. Mao   +34 more
core   +1 more source

Down‐regulation of Shh in the hair follicles of mice during chemotherapy‐induced hair loss is mediated by the JAK/STAT1 signaling pathway

FEBS Open Bio, EarlyView.
We found that during chemotherapy‐induced alopecia (CIA), Sonic hedgehog (Shh) expression significantly decreased in hair follicle Shh+ cells, whereas the Janus‐activated kinase/signal transducer and activator of transcription 1 (JAK/STAT1) signaling pathway was markedly activated.
Ruifang Fan, Jingling Huang, Xiang Lin, Tingjiao Lan, Yuli Tang, Ling Sun, Guixuan Zhou   +6 more
wiley   +1 more source

Influence of the Hot-Top Thermal Regime on the Severity and Extent of Macrosegregation in Large-Size Steel Ingots

Journal of Manufacturing and Materials Processing
The influence of hot-top designs with different heat capacities on the distribution of positive and negative macrosegregation was investigated on a 12 metric tonne (MT) cast ingot made using Cr-Mo low-alloy steel.
Neda Ghodrati, Henri Champliaud, Jean-Benoit Morin, Mohammad Jahazi   +3 more
doaj   +1 more source

Thermodynamic Properties of κ-(BEDT-TTF)2X Salts: Electron Correlations and Superconductivity

Crystals, 2012
Heat capacity measurements of κ-(BEDT-TTF)2X (BEDT-TTF: Bis(ethylendithio) tetrathiafulvalene, X: counteranions) which are classified as two-dimensional (2D) dimer-Mott system are reported.
Yasuhiro Nakazawa, Satoshi Yamashita
doaj   +1 more source

Heat capacity of square-well fluids of variable width

, 2003
We have obtained by Monte Carlo NVT simulations the constant-volume excess heat capacity of square-well fluids for several temperatures, densities and potential widths.
A. SANTOS, Barker J. A., J. LARGO, J. R. SOLANA, L. ACEDO   +4 more
core   +1 more source

FGFR Like1 drives esophageal cancer progression via EMT, PI3K/Akt, and notch signalling: insights from clinical data and next‐generation sequencing analysis

FEBS Open Bio, EarlyView.
Clinical analysis reveals significant dysregulation of FGFRL1 in esophageal cancer (EC) patients. RNAi‐coupled next‐generation sequencing (NGS) and in vitro study reveal FGFRL1‐mediated EC progression via EMT, PI3K/Akt, and Notch pathways. Functional assays confirm its role in tumor growth, migration, and invasion.
Aprajita Srivastava, Anoop Saraya, Deepak Gunjan, Rinu Sharma   +3 more
wiley   +1 more source