Results 71 to 80 of about 4,466,317 (351)

Large‐scale bidirectional arrayed genetic screens identify OXR1 and EMC4 as modifiers of αSynuclein aggregation

FEBS Open Bio, EarlyView.
Activation of the mitochondrial protein OXR1 increases pSyn129 αSynuclein aggregation by lowering ATP levels and altering mitochondrial membrane potential, particularly in response to MSA‐derived fibrils. In contrast, ablation of the ER protein EMC4 enhances autophagic flux and lysosomal clearance, broadly reducing α‐synuclein aggregates.
Sandesh Neupane, Lea Nikolić, Lorenzo Maraio, Thomas Goiran, Nathan Karpilovsky, Stefano Sellitto, Vangelis Bouris, Jiang‐An Yin, Ronald Melki, Edward A Fon, Adriano Aguzzi, Elena De Cecco   +11 more
wiley   +1 more source

Application of Second Law Analysis in Heat Exchanger Systems

Entropy, 2019
In recent decades, the second law of thermodynamics has been commonly applied in analyzing heat exchangers. Many researchers believe that the minimization of entropy generation or exergy losses can be considered as an objective function in designing heat
Seyed Ali Ashrafizadeh
doaj   +1 more source

An Evaluation of Heat Exchangers Using System Information and PEC [PDF]

, 2000
This report describes analyses aimed at integrating component optimization and system design by developing heat-exchanger performance evaluation criteria (PEC) that account for the system-level performance impacts of heat exchanger design. It builds on
Bullard, C.W., Jacobi, A.M., Pira, J.V.
core  

Identifying transcription factors controlling the basal expression of human MRP4 highlights a substantial role for Sp1

FEBS Open Bio, EarlyView.
The MRP4 transporter exports several drugs and signaling molecules. Here, we identified key promoter elements regulating basal MRP4 expression. Using reporter assays, we defined a conserved region with essential Sp1 and contributory Ets sites, which controlled basal MRP4 expression.
Debora Singer, Angelique Kragl, Katrin Ziems, Juliane Glaubitz, Sophie Grammbauer, Susanne Hildebrandt, Mladen V. Tzvetkov, Gabriele Jedlitschky   +7 more
wiley   +1 more source

MODELING OF HEAT EXCHANGE IN A CONDENSATION HEAT EXCHANGER

Thermophysics and Thermal Power Engineering
The scientific approach in the study is based on computational modeling of heat transfer processes in conditions of two-phase interaction of heat carriers. The study involves the use of a combination of analytical and numerical methods: computational relations for the Nusselt, Prandtl, Reynolds criteria, as well as iterative procedures using the ...
A.V. Nedilko, Ye.V. Novakivskyi
openaire   +1 more source

Mechanochemical Synthesis and Characterization of Nanostructured ErB4 and NdB4 Rare‐Earth Tetraborides

Advanced Engineering Materials, Volume 27, Issue 6, March 2025.
ErB4 and NdB4 nanostructured powders are produced by mechanochemical synthesis. 5 h mechanical alloying and 4 M HCl acid leaching are used in the production. ErB4 and NdB4 powders exhibit maximum magnetization of 0.4726 emu g−1 accompanied with an antiferromagnetic‐to‐paramagnetic phase transition at about TN = 18 K and 0.132 emu g−1 with a maximum at ...
Burçak Boztemur, Faruk Kaya, Bora Derin, Mustafa Lütfi Öveçoğlu, Ju Li, Duygu Ağaoğulları   +5 more
wiley   +1 more source

Solar-energy conversion system provides electrical power and thermal control for life-support systems [PDF]

, 1974
System utilizes Freon cycle and includes boiler turbogenerator with heat exchanger, regenerator and thermal-control heat exchangers, low-pressure and boiler-feed pumps, and condenser. Exchanger may be of interest to engineers and scientists investigating
Davis, B. K.
core   +1 more source

Harnessing Fungal Biowelding for Constructing Mycelium‐Engineered Materials

Advanced Engineering Materials, EarlyView.
Mycelium‐bound composites (MBCs) offer low‐carbon alternatives for construction, yet interfacial bonding remains a critical challenge. This review examines fungal biowelding as a biocompatible adhesive, elucidating mycelium‐mediated interfacial mechanisms and their role in material assembly. Strategies to optimize biowelding are discussed, highlighting
Xue Brenda Bai, Xinrui Sarah Niu, Zhao Qin   +2 more
wiley   +1 more source

Research Progress in Supercritical CO2 Microchannel Heat Exchangers

Zhileng xuebao, 2023
In the context of the "3060 carbon peaking and carbon neutrality goals", promoting energy-efficient transportation and rational utilization is one of the important paths to achieve carbon neutrality, where heat exchangers are known to play a crucial role.
Huang Junjie, Han Zengxiao, Guo Jiangfeng, Huai Xiulan   +3 more
doaj  

Innovative Processing of Compacted Waste Aluminum Alloy Powders via Controlled Remelting and Solidification

Advanced Engineering Materials, EarlyView.
This study demonstrates an efficient recycling route for out‐of‐spec AlSi10Mg atomized powders through compaction and arc remelting followed by suction casting. By correlating compaction load, cooling rate, and resulting microstructure, we show that intermediate pressures (50–80 kN) and rapid cooling refine dendrites, reduce porosity, and enhance ...
Mila Christy de Oliveira, Marcella Gaute Cavalcante Xavier, Abdoul‐Aziz Bogno, Piter Gargarella, José Eduardo Spinelli   +4 more
wiley   +1 more source