Results 51 to 60 of about 34,284 (244)

Tumor‐Derived LAMB3 Drives Immunosuppressive LRRC15+ Fibroblast Formation During Pancreatic Ductal Adenocarcinoma Development

Advanced Science, EarlyView.
A single‐cell atlas of pancreatic ductal adenocarcinoma development reveals progressive ductal‐fibroblast‐immune crosstalk. Tumor‐derived LAMB3 drives the formation of immunosuppressive LRRC15+ fibroblasts through the ITGB1/FAK/MAPK/FOSL2 signaling. Glycolytic reprogramming upregulates LAMB3 and correlates with LRRC15+ fibroblast enrichment.
Xuqing Shi, Hangqi Liu, Jianru Sun, Xiaoding Liu, Xinping Jv, Longyun Chen, Yuhan Zhang, Hui Zhang, Xudong Xing, Ruiyu Li, Xinyi Ke, Jun Wang, Xianglin Yin, Bohan Liu, Qixian Liu, Yuan Wang, Junliang Lu, Shiyi Liu, Junyi Pang, Yumeng Cai, Menghua Dai, Fan Bai, Huanwen Wu, Zhiyong Liang   +23 more
wiley   +1 more source

Mitigating Cancer Therapy–Related Cognitive Impairment by Targeted Activation of Undruggable Phosphatase

Advanced Science, EarlyView.
An RVG‑engineered exosomal saRNA delivery system (RVG‑EVs‑saPtpro) effectively targets and activates hippocampal PTPRO, functioning as a “molecular brake” to alleviate cancer therapy‑related cognitive impairment (CTRCI) by enhancing neuronal survival, neurogenesis, and synaptic plasticity.
Zhimeng Yao, Yuhua Meng, Huanyi Li, Yinhui Jiang, Xiaona Lin, Mengyuan Hu, Qing Liu, Xiaofu Qiu, Hongzheng Ren, Yunlong Pan, Bin Pan, Zexiong Guo, Shuyao Zhang, Dianzheng Zhang, Li Yang, Shegan Gao, Weijing Deng, Jianfan Chen, Hao Zhang   +18 more
wiley   +1 more source

Single‐Cell Dissection of Therapy‐Induced Remodeling Uncovers a Fibroblast‐Driven Immunosuppressive Niche and Targetable Vulnerabilities in Lethal Prostate Cancer

Advanced Science, EarlyView.
Single‐cell longitudinal profiling reveals that androgen‐deprivation therapy induces a DPT+ fibroblast‐complement axis that suppresses macrophage inflammation and drives CD8+ T cell exhaustion in prostate cancer. Concurrently, resistant epithelial subpopulations persist and engage TSPAN1‐ and NRXN1‐mediated programs promoting CRPC and neuroendocrine ...
Yang Chen, Dandan Dong, Jinling Liao, Naikai Liao, Mengqi Liu, Qin Zhang, Siting Chen, Qi Liu, Ying Lu, Tianyu Li, Chunlin Zou, Qiong Song, Qiuyan Wang, Jian Liang, Qiji Xie, Chengyang Li, Mengyun Wang, Jiwen Cheng, Zengnan Mo, Gong‐Hong Wei   +19 more
wiley   +1 more source

Recent Advances in Laser‐Induced Graphene‐Based Gas Sensors: From Sensing Mechanisms to Biomedical Applications

Advanced Science, EarlyView.
Laser‐induced graphene (LIG) provides a scalable, laser‐direct‐written route to porous graphene architecture with tunable chemistry and defect density. Through heterojunction engineering, catalytic functionalization, and intrinsic self‐heating, LIG achieves highly sensitive and selective detection of NOX, NH3, H2, and humidity, supporting next ...
Md Abu Sayeed Biswas, Ankan Dutta, Shuvendu Das, Abu Musa Abdullah, Wanqing Zhang, Fatema Tuz Zohra, Huanyu Cheng   +6 more
wiley   +1 more source

Ultrasensitive biosensing meta-garment via wetting gradient effect for heat-exhaustion warning

npj Flexible Electronics
Heat exhaustion is a prevalent heat-related illness among firefighters, posing a severe threat to life without timely intervention. However, current firefighter garments are limited by their singular functionality and cannot collect or analyze body fluid
Ming Li, Ganghua Li, Zengqing Li, Yalin Tang, Ruidong Xu, Tong Xu, Yiwen Wang, Yuanyuan Liu, Lijun Qu, Binghao Wang, Yingkui Yang, Mingwei Tian   +11 more
doaj   +1 more source

Theoretical prediction of decomposition temperature of typical heat-resistant explosives

Chemical Physics Impact, 2020
With the approaching exhaustion of shallow-ground gas and oil, heat-resistant explosives are in highly demand in oil/gas ultra-deep and ocean well development.
Chuan Guo Chai, Kaiyuan Tan, Guijuan Fan, Yong Han, Jingming Li, Ming Li, Xinping Long, Bisheng Tan, Hui Huang   +8 more
doaj   +1 more source

An Integrated NLP‐ML Framework for Property Prediction and Design of Steels

Advanced Science, EarlyView.
This study presents a data‐driven framework that uses language‐processing techniques to interpret steel processing descriptions and machine‐learning models to predict mechanical properties. By organising complex process histories into meaningful groups and enabling rapid property forecasts, the work supports faster, more informed steel design through ...
Kiran Devraju, Adithya Umanath Rai, Jose Thomson, Marzie Ghorbani, Shujing Zhao, Nick Birbilis   +5 more
wiley   +1 more source

Study of Epidemiological Determinants of Patients Presented with “Heat Wave Related Illness” Admitted in Tertiary Care Center

National Journal of Community Medicine, 2019
Context: Heat related illnesses (HRI) though preventable are in- creasing worldwide. People living in developing countries like In- dia are at greater risk.
Dhara Bhavesh Roy, Harsh V Khatri, Ami P Parikh   +2 more
doaj  

Epidemiological characteristics of heat-related illness: a nationwide study in Taiwan

BMC Public Health
Background Heat-related illness (HRI) is expected to occur more frequently and become a prominent issue worldwide in the context of global warming and climate change.
Wan-Yin Kuo, Chien-Cheng Huang, Chi-An Chen, Chung-Han Ho, Chien-Chin Hsu, Hung-Jung Lin, Shih-Bin Su, Jhi-Joung Wang, How-Ran Guo   +8 more
doaj   +1 more source

Evidence-Based Guidelines Regarding Heat-Related Illness among Faculty of Physical Education Students [PDF]

Egyptian Journal of Health Care
             Background: Heat-related illnesses (HRI) are serious issues resulting from increase body temperature, it can be caused by either environmental conditions or exertion, including minor conditions such as heat cramps, heat exhaustion, and heat ...
Alaa Mohammed Elsayed, Ebtesam Abaas Hassan, Mona Abobakr Abd Ellatif   +2 more
doaj   +1 more source