Results 71 to 80 of about 503,620 (268)

Engineering IL‐4 resistant proinflammatory human myeloid cells for cancer immunotherapy

Molecular Oncology, EarlyView.
We developed a scalable workflow to generate proinflammatory human myeloid cells. CRISPR/Cas9‐edited CD34+ hematopoietic stem and progenitor cells were expanded and differentiated with M‐CSF. Deletion of STAT6 or STAT6/NFKB1 enhanced macrophage proinflammatory gene expression and cytokine secretion in the presence of IL‐4 while maintaining antibody ...
Theresa Barberi, Alan D. Friedman
wiley   +1 more source

Temporal trends and disparities in heat-related cardiovascular mortality in the United States (1999–2024): a CDC WONDER analysis

Frontiers in Cardiovascular Medicine
Rising global temperatures and increasing frequency of extreme heat events have raised growing concerns regarding heat-related cardiovascular mortality.
Hassaan Abid, Gaaitri Lohano, Muhammad Vazaym, Muhammad Jawad, Rimsha Adnan, Muhammad Mohid Haroon   +5 more
doaj   +1 more source

Single‐molecule DNA flow‐stretch assays for high‐throughput DNA–protein interaction studies

FEBS Open Bio, EarlyView.
We describe an optimised single‐molecule DNA flow‐stretch assay that visualises DNA–protein interactions in real time. Linear DNA fragments are tethered to a surface and stretched by buffer flow for fluorescence imaging. Using λ and φX174 DNA, this protocol enhances reproducibility and accessibility, providing a versatile approach for studying diverse ...
Ayush Kumar Ganguli, Mohammad Nour Alsamsam, Ugnė Bagdonaitė, Van Truc Vu, Chun‐Jen Huang, Polina Kuzhir, Mindaugas Zaremba, Aurimas Kopūstas, Marijonas Tutkus   +8 more
wiley   +1 more source

Cyclic variations in incubation conditions induce adaptive responses to later heat exposure in chickens: a review

Animal, 2015
Selection programs have enabled broiler chickens to gain muscle mass without similar enlargement of the cardiovascular and respiratory systems that are essential for thermoregulatory efficiency.
T. Loyau, L. Bedrani, C. Berri, S. Métayer-Coustard, C. Praud, V. Coustham, S. Mignon-Grasteau, M.J. Duclos, S. Tesseraud, N. Rideau, C. Hennequet-Antier, N. Everaert, S. Yahav, A. Collin   +13 more
doaj   +1 more source

Aquaporin‐3 and aquaporin‐5 impact the development of pancreatic ductal adenocarcinoma spheroids

FEBS Open Bio, EarlyView.
Schematic representation of the role of aquaporin‐3 (AQP3) and aquaporin‐5 (AQP5) in pancreatic ductal adenocarcinoma (PDAC). Both proteins are upregulated in PDAC and are associated with tumor progression and metastatic potential. Silencing AQP3 or AQP5 in PDAC spheroids results in decreased diameter, area, and overall growth, underscoring their key ...
Catarina Pimpão, Diogo M. Engrácia, Graça Soveral, Filipa Mendes   +3 more
wiley   +1 more source

Effects of prenatal PM2.5 and heat exposure on offspring body weight gain and thyroid hormone levels in rats

环境与职业医学
BackgroundThe escalating challenges of fine particulate matter (PM2.5) pollution and global warming pose significant threats to human health. Previous studies have demonstrated that prenatal exposure to PM2.5 and heat is associated with restricted fetal ...
Huijun LI, Huailin WANG, Wulayin Maimaitiminjiang, Yuyuan BU, Qiong WANG   +4 more
doaj   +1 more source

Molecular characterization of covRS mutations in M1UK Streptococcus pyogenes

FEBS Open Bio, EarlyView.
Group A Streptococcus (GAS) acquires covRS mutations driving a hypervirulent bacterial state, frequently associated with invasive disease‐like necrotizing fasciitis. We demonstrate that the newly emerged M1UK GAS lineage can also acquire these mutations.
Jarrad Pritchard, Emma‐Jayne Proctor, Jiawa Wang, Nikolas P. Johnston, Andrew Hayes, Georgia McCorkell, Haibo Yu, Jai Tree, Mark R. Davies, Mark J. Walker, Ronald Sluyter, Stephan Brouwer, Martina L. Sanderson‐Smith   +12 more
wiley   +1 more source

Moving toward a more human-oriented analysis of urban heat: examining differences of heat exposure intensity at busy commuting locations

Environmental Research: Health
Examining urban thermal environments has become a critical area of research spanning epidemiology, urban planning, and ecology. While traditional metrics like air temperature ( T _air ) and satellite-derived surface temperature dominate urban heat ...
Peter C Ibsen, Melissa R Mchale, Priyanka Desouza, Logan Steinharter, Carl Green Jr, Jay E Diffendorfer, Travis Warziniack   +6 more
doaj   +1 more source

Effect of terahertz irradiation on DNA damage repair in living cells

FEBS Open Bio, EarlyView.
We investigated the effect of terahertz (THz) wave irradiation on DNA double‐strand break (DSB) repair in living cells. We found that THz irradiation enhanced DSB repair at specific frequencies, whereas heat treatment inhibited it, indicating that this effect is nonthermal and frequency‐specific.
Yuya Ueno, Shota Yamazaki, Hiromichi Hoshina, Masahiko Harata   +3 more
wiley   +1 more source

Heat metrics and thresholds reshape population exposure and inequality signals

Environmental Research Letters
Extreme heat is intensifying worldwide, yet estimates of heat hazard and exposure inequality depend on both the heat metric and how extreme days are defined.
Liutao Chen, TC Chakraborty, Joan A Casey, Ching-Hsuan Huang, Tzu-Hsin Karen Chen   +4 more
doaj   +1 more source