Results 51 to 60 of about 503,620 (268)
LifeClimate-related hazards are associated with adverse mental and physical health outcomes, but exposure-specific human findings are often discussed together with general stress mechanisms without clearly distinguishing their evidentiary strength.
Giuseppe Marano +9 more
doaj +1 more source
Heat exposure induces tissue stress in heat-intolerant, but not heat-tolerant, mice
Stress, 2012 We investigated the association of systemic and local tissue stress responses with heat-tolerant (TOL) levels in mice. Thirty-eight mice were assigned into control and three heat exposure groups-TOL, moderately tolerant, and intolerant (INT), based on their overall thermal responses.
Aminul, Islam +5 more
openaire +2 more sources
Molecular Oncology, EarlyView.Breast cancer remains a major cause of cancer death in women, frequently developing endocrine therapy resistance. This study demonstrates that upregulated p21‐activated kinase 1 (PAK1) activity drives resistance to tamoxifen and long‐term estrogen deprivation in ER+ breast cancer models.
Luisa Schwarzmüller +10 more
wiley +1 more source
Materials Research, 2010 This paper deals with the post fire behavior of hybrid nanocomposites under dynamic loadings. A series of tests were performed to investigate how nanoparticles (i.e.
Antonio Ferreira Ávila +6 more
doaj +1 more source
The Effects of Heat Exposure on Human Mortality Throughout the United States
GeoHealth, 2020 Exposure to high ambient temperatures is an important cause of avoidable, premature death that may become more prevalent under climate change. Though extensive epidemiological data are available in the United States, they are largely limited to select ...
Drew Shindell +5 more
doaj +1 more source
Molecular Oncology, EarlyView.LUNAR is a liver‐specific long noncoding RNA (lncRNA) that is highly expressed in normal liver but becomes epigenetically silenced in hepatocellular carcinoma through promoter hypermethylation. Loss of LUNAR is associated with NOTCH activation, epithelial–mesenchymal transition, and metastasis, whereas restoring LUNAR restrains metastatic progression ...
Se Ha Jang +9 more
wiley +1 more source
Extreme heat and the risk of fatal industrial accidents: nationwide evidence from China
Environmental Research CommunicationsExtreme heat poses a growing threat to occupational safety under accelerating climate change, yet evidence of its effects on severe and fatal industrial accidents remains limited.
Husel Husile
doaj +1 more source
Wellcome Open ResearchBackground Extreme heat exposure — defined as sustained ambient temperatures exceeding local thresholds — has been associated with several adverse pregnancy outcomes, including preterm birth, stillbirth, gestational diabetes and small for gestational age.
Jane E Hirst +43 more
doaj +1 more source
PANoptosis in the pathogenesis of myelodysplastic syndromes
Molecular Oncology, EarlyView.PANoptosis, a combination of three types of programmed cell death, is mediated by a large protein complex called a PANoptosome. In healthy bone marrow hematopoietic cells, PANoptosis is restricted by inhibitory signaling. In MDS, bone marrow cells become sensitive to the PANoptotic stimuli due to the aberrant inactivation of inhibitory signaling or ...
Rohit Thalla +4 more
wiley +1 more source
The VHL tumor suppressor at the crossroad of protein folding, aggregation, and cancer
Molecular Oncology, EarlyView.Mutations, environmental stress, and chaperone dysfunction can destabilize pVHL, promoting its conversion from the native folded state into amyloid‐like assemblies. This transition may contribute to protein storage, cell dormancy, survival, and drug resistance.
Lara Abad +2 more
wiley +1 more source