Results 41 to 50 of about 11,917 (168)
FEBS Letters, EarlyView.The mycobacterial CIII‐CIV respiratory supercomplex is an obligate assembly, encompassing several subunits of unknown functions. We have characterized the intracellular subunit AscF, and show that it is unlikely to be a sensor for metals or nucleotides, but is required for growth on nonfermentable energy sources, and likely works as an adapter for ...
Eni Rile +8 more
wiley +1 more source
An epithelial GPR35 isoform supports tumor‐associated transcriptional and metabolic phenotypes
FEBS Letters, EarlyView.GPR35 generates two functionally distinct isoforms with previously unresolved roles. GPR35‐short mediates immune‐cell chemotaxis, while GPR35‐long is enriched in colorectal cancer epithelium, where it supports increased metabolism, proliferation, and tumor‐associated transcriptional programs.
Jørgen D. Rønneberg +14 more
wiley +1 more source
Molecular Oncology, EarlyView.Loss of the miR‐214/199a cluster is associated with recurrence in ovarian cancer. Engineered small extracellular vesicles (m214‐sEVs) elevate miR‐214‐3p/miR‐199a‐5p in tumor cells, suppress β‐catenin, TLR4, and YKT6 signaling, reprogram tumor‐derived sEV cargo, reduce chemoresistance and migration, and enhance carboplatin efficacy and survival in ...
Weida Wang +12 more
wiley +1 more source
Journal of Ophthalmology, 2019 Background: Assessment of heat exchange processes in the human body is based on temperature and heat flux measurements. Today, there is no instrument for measuring the heat flux density from the eye.
L.I. Anatychuk +5 more
doaj +1 more source
Molecular Oncology, EarlyView.Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla +9 more
wiley +1 more source
Model Investigation of Subcooled Flow Boiling in Narrow Rectangular Channel Using CFD Method
Yuanzineng kexue jishu, 2022 The plate-type fuel assembly with the advantages of high specific power of active zone and compact structure has been widely adopted in many research reactors and material irradiation test reactors.
LIU Kai;LI Linfeng;WANG Mingjun;ZHANG Jing;TIAN Wenxi;QIU Suizheng;SU Guanghui
doaj
An estimate of the surface heat fluxes transfer of the Persian Gulf with the overlying atmosphere
Journal of Radiation Research and Applied Sciences, 2015 The ocean heat exchange process is a key mechanism in climate variations over a broad time – scale. In this study, the long–term mean surface heat fluxes over the Persian Gulf have been estimated by the empirical relations using data derived from ...
A. Rezaei-Latifi, F. Hosseinibalam
doaj +1 more source
Molecular Oncology, EarlyView.RNA profiling of circulating extracellular vesicles (EVs) from blood samples of men undergoing prostate biopsy identifies transcripts associated with clinically significant prostate cancer. Integrative analysis with public tumor datasets links EV‐derived gene signatures to tumor stage and progression‐free survival, highlighting CASP3, XRCC2, and RIT1 ...
Stefan Werner +14 more
wiley +1 more source
Wall heat flux measurements in a GO2/GH2 heat-sink combustion chamber
Journal of Thermal Science and Technology, 2018 In order to understand heat transfer mechanisms in the combustion chamber with multi-elements injector and provide benchmark data of wall heat fluxes for the CFD code validation, experiments were carried out in a GH2/GO2 heat-sink combustion chamber.
Taiping WANG +3 more
doaj +1 more source
Molecular Oncology, EarlyView.Combining osimertinib with the STING agonist ADU‐S100 activates innate and adaptive immunity to overcome the non‐inflamed microenvironment of Egfr‐mutant lung cancer. This combination increases NK and CD8+ T‐cell infiltration, associated with activation of the STING‐IRF3 pathway and local immunogenic cell death.
Jun Nishimura +19 more
wiley +1 more source