Results 61 to 70 of about 11,917 (168)
Molecular Oncology, EarlyView.The proposed mechanism of action for the CDK12/13 inhibitor and cyclin K degrader, CT7439. CDK12/13 inhibition interrupts transcription elongation, leading to increased DNA damage that results in cell death. This agent is a potentially novel treatment option for patients with colorectal cancer. Created in BioRender. Cyclin‐dependent kinase (CDK) 12 and
Wylie K. Watlington +10 more
wiley +1 more source
Molecular Oncology, EarlyView.BCL9 and BCL9L drive bladder cancer progression by enhancing β‐catenin signaling, promoting proliferation, migration, invasion, and organoid growth. Genetic depletion of BCL9(L) suppresses malignant phenotypes, while pharmacological disruption of the β‐catenin/BCL9(L) complex with ZW4864 inhibits canonical Wnt signaling and tumor‐associated cellular ...
Roland Kotolloshi +11 more
wiley +1 more source
Application of the Critical Heat Flux Look-Up Table to Large Diameter Tubes
Science and Technology of Nuclear Installations, 2013 The critical heat flux look-up table was applied to a large diameter tube, namely 67 mm inside diameter tube, to predict the occurrence of the phenomenon for both vertical and horizontal uniformly heated tubes. Water was considered as coolant.
M. El Nakla +5 more
doaj +1 more source
Molecular Oncology, EarlyView.LUNAR is a liver‐specific long noncoding RNA (lncRNA) that is highly expressed in normal liver but becomes epigenetically silenced in hepatocellular carcinoma through promoter hypermethylation. Loss of LUNAR is associated with NOTCH activation, epithelial–mesenchymal transition, and metastasis, whereas restoring LUNAR restrains metastatic progression ...
Se Ha Jang +9 more
wiley +1 more source
Heat Flux at the Surface of Metal Foil Heater under Evaporating Sessile Droplets
International Journal of Aerospace Engineering, 2015 Evaporating water drops on a horizontal heated substrate were investigated experimentally. The heater was made of a constantan foil with the thickness of 25 μm and size of 42 × 35 mm2.
Igor Marchuk +3 more
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Molecular Oncology, EarlyView.Interferon type 1 (IFN‐1) production and signaling is associated with the acquisition of therapy resistance, following chronic DNA damage, via Interferon‐related DNA damage resistance signature (IRDS) gene expression. An alternative, DNA damage‐independent role of sustained IFN‐1 mediated resistance was identified and characterized by the emergence of ...
Ashlyn Conant +11 more
wiley +1 more source
Frontiers in Marine ScienceThe observational data of the air-sea interface and upper ocean elements from a buoy array deployed in the northern South China Sea from June to November 2014 is analyzed.
Zixi Wu, Han Zhang, Han Zhang, Han Zhang
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CEACAM1 participation in breast cancer progression
Molecular Oncology, EarlyView.In invasive breast cancer (BC), CEACAM1 shifts from an apical to a uniform membranous/cytoplasmic pattern, or is lost, as tumors dedifferentiate, inversely tracking the Ki‐67 proliferative index. In MCF‐7 cells, only CEACAM1‐4L suppresses proliferation, repressing cell cycle and growth factor genes.
Mykola Lyndin +3 more
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Zhileng xuebao, 2016 Experiments are performed in rectangular micro-channels (dH =0.293 mm) under the condition of different mass flux and heat flux to evaluate the flow boiling heat transfer characteristics with deionized water and anhydrous ethanol.
Chen Yumin, Liu Dongyao
doaj
FEBS Open Bio, EarlyView.Time‐resolved X‐ray solution scattering captures how proteins change shape in real time under near‐native conditions. This article presents a practical workflow for light‐triggered TR‐XSS experiments, from data collection to structural refinement. Using a calcium‐transporting membrane protein as an example, the approach can be broadly applied to study ...
Fatemeh Sabzian‐Molaei +3 more
wiley +1 more source