Results 61 to 70 of about 182,887 (314)

Mixed‐class J‐domain protein scaffolds promote expanded aggregate handling and multivalent Hsp70 engagement during functional disaggregase assembly

FEBS Letters, EarlyView.
Protein aggregates threaten proteostasis and cell health. In human cells, Hsp70–J‐domain protein‐based disaggregases remove aggregates, but how they assemble remains unclear. Our biochemical findings show that DNAJA2‐ and DNAJB1‐containing disaggregase scaffolds enhance luciferase aggregate targeting, and that Hsp70 recruitment by both J‐domain ...
Anna Szlachcic, Nadinath B. Nillegoda
wiley   +1 more source

An estimate of the surface heat fluxes transfer of the Persian Gulf with the overlying atmosphere

Journal of Radiation Research and Applied Sciences, 2015
The ocean heat exchange process is a key mechanism in climate variations over a broad time – scale. In this study, the long–term mean surface heat fluxes over the Persian Gulf have been estimated by the empirical relations using data derived from ...
A. Rezaei-Latifi, F. Hosseinibalam
doaj   +1 more source

TRAIL‐PEG‐Apt‐PLGA nanosystem as an aptamer‐targeted drug delivery system potential for triple‐negative breast cancer therapy using in vivo mouse model

Molecular Oncology, EarlyView.
Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat, Aslihan Kucuk, Omer Erdogan, Samed Ozer, Bensu Kozan, Tugba Cuceli, Erkan Gumus, Evrim Cevik, Ozge Cevik   +8 more
wiley   +1 more source

Engineered extracellular vesicles enriched with the miR‐214/199a cluster enhance the efficacy of chemotherapy in ovarian cancer

Molecular Oncology, EarlyView.
Loss of the miR‐214/199a cluster is associated with recurrence in ovarian cancer. Engineered small extracellular vesicles (m214‐sEVs) elevate miR‐214‐3p/miR‐199a‐5p in tumor cells, suppress β‐catenin, TLR4, and YKT6 signaling, reprogram tumor‐derived sEV cargo, reduce chemoresistance and migration, and enhance carboplatin efficacy and survival in ...
Weida Wang, Ayesha Alvero, Yi Qin, Mingjin Wang, Alexandra Fox, Yanfeng Li, Michael Millman, Amy Kemper, Gil Mor, Xian Shuang Liu, Michael Chopp, Zheng Gang Zhang, Yi Zhang   +12 more
wiley   +1 more source

Compound effect of EHD and surface roughness in pool boiling and CHF with R-123

, 2011
This article is a post-print version of the fianl published article which may be accessed at the link below.Saturated pool boiling of R-123 at 1 bar, including the critical heat flux (CHF), was enhanced by modifying the surface characteristics and ...
T.G. Karayiannis, Kenning, D.B.R., D.B.R. Kenning, Ahmad, S.W., Luke, A, Luke, A., Karayiannis, TG, Kenning, DBR, S.W. Ahmad, Ahmad, SW, Karayiannis, T.G., A. Luke   +11 more
core   +1 more source

Fast-Response transient heat flux measurements in a plasma wind tunnel

, 2021
A fast response heat transfer gauge has been developed to measure the radial distribution and the fluctuations of heat flux in a supersonic arcjet plasma wind tunnel.
Loehle, Stefan, Hufgard, Fabian, Buttsworth, David, Birch, Byrenn   +3 more
core   +1 more source

IMPDH inhibition enhances cytarabine efficacy in SAMHD1‐expressing leukaemia cells via guanine nucleotide depletion

Molecular Oncology, EarlyView.
Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla, Christopher Dirks, Caroline Eiden, Sonja K. Fesenmayer, Femke M. Hormann, Yolande Klootsema, Ingrid Lilienthal, Si Min Zhang, Nikolas Herold, Sean G. Rudd   +9 more
wiley   +1 more source

Flow patterns and heat transfer for flow boiling in small to micro diameter tubes

, 2008
An overview of the recent developments in the study of flow patterns and boiling heat transfer in small to micro diameter tubes is presented. The latest results of a long-term study of flow boiling of R134a in five vertical stainless steel tubes of ...
Karayiannis, TG, Shiferaw, D, Kenning, DBR, Wadekar, VV   +3 more
core  

Model Investigation of Subcooled Flow Boiling in Narrow Rectangular Channel Using CFD Method

Yuanzineng kexue jishu, 2022
The plate-type fuel assembly with the advantages of high specific power of active zone and compact structure has been widely adopted in many research reactors and material irradiation test reactors.
LIU Kai;LI Linfeng;WANG Mingjun;ZHANG Jing;TIAN Wenxi;QIU Suizheng;SU Guanghui
doaj  

Comparison of the high temperature heat flux sensor to traditional heat flux gages under high heat flux conditions. [PDF]

, 2013
Four types of heat flux gages (Gardon, Schmidt-Boelter, Directional Flame Temperature, and High Temperature Heat Flux Sensor) were assessed and compared under flux conditions ranging between 100-1000 kW/m2, such as those seen in hydrocarbon fire or propellant fire conditions.
Blanchat, Thomas K., Hanks, Charles R.
openaire   +1 more source