Results 71 to 80 of about 182,887 (314)
E2A selectively regulates TGF‐β–induced apoptosis in KRAS‐mutant non‐small cell lung cancer
Molecular Oncology, EarlyView.Ability to induce apoptosis by TGF‐β is frequently lost in advanced lung adenocarcinoma despite intact TGF‐β signaling. We identify E2A as a mutant KRAS–dependent mediator of resistance to TGF‐β–induced apoptosis. TGF‐β induces E2A via SMAD3 in mutant KRAS cells, and E2A silencing restores apoptosis and enhances radiation response in cell lines ...
Sergei Chuikov +3 more
wiley +1 more source
Geochemistry, Geophysics, GeosystemsUnderstanding surface heat flux is essential for evaluating geothermal system dynamics and resource potential, particularly in tectonically active but non‐volcanic regions. This study presents the first integrated assessment of surface heat flux in three
Yingchun Wang +4 more
doaj +1 more source
Molecular Oncology, EarlyView.EXOSC10, an essential nuclear RNA exosome‐associated 3′‐5′ exoribonuclease, is inhibited by the anticancer drug 5‐fluorouracil (5‐FU), and EXOSC10 depletion increases 5‐FU sensitivity. The colon‐cancer variant EXOSC10S402T, located in a proteolysis motif, is stable and nuclear but nonfunctional in vivo.
Radhika Sain +10 more
wiley +1 more source
, 2010 A combination of lithography-based microfabrication and micro end milling is used to manufacture thin-film resistance temperature detector (RTD) heat flux sensors on bulk copper substrates.
Jasperson, Benjamin A. +3 more
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An analytical investigation of the physical dimensions of natural convection flow on a vertical heated plate [PDF]
, 2010 Analytical results of the boundary layer of natural convection air flow on a vertical heated plate are presented for both isothermal and constant heat flux plates.
Alzwayi, A.S., Paul, M.C.
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Transient response of an erodable heat flux gauge using finite element analysis
, 2002 The transient response of an erodable ribbon element heat flux gauge has been assessed using a two-dimensional finite element (FE) analysis. Such transient heat flux gauges have previously been used for measurements in internal combustion (IC) engines ...
Buttsworth, David R., D R Buttsworth
core +1 more source
Wall heat flux measurements in a GO2/GH2 heat-sink combustion chamber
Journal of Thermal Science and Technology, 2018 In order to understand heat transfer mechanisms in the combustion chamber with multi-elements injector and provide benchmark data of wall heat fluxes for the CFD code validation, experiments were carried out in a GH2/GO2 heat-sink combustion chamber.
Taiping WANG +3 more
doaj +1 more source
Molecular Oncology, EarlyView.RNA profiling of circulating extracellular vesicles (EVs) from blood samples of men undergoing prostate biopsy identifies transcripts associated with clinically significant prostate cancer. Integrative analysis with public tumor datasets links EV‐derived gene signatures to tumor stage and progression‐free survival, highlighting CASP3, XRCC2, and RIT1 ...
Stefan Werner +14 more
wiley +1 more source
Molecular Oncology, EarlyView.Here, we demonstrate that HS1BP3 interacts with Cortactin through a proline‐rich region (PRR3.1) and show that this interaction, and HS1BP3 itself, promote cancer cell proliferation and invasion. Inhibition of this interaction leads to build‐up of TKS5 in multivesicular endosomes and altered secretion of CD63 and CD9, providing an explanation for the ...
Arja Arnesen Løchen +9 more
wiley +1 more source
R134a flow boiling heat transfer in small diameter tubes
, 2007 Copyright @ 2007 RT Edwards Inc.Boiling heat transfer in small diameter tubes has been experimentally investigated using R134a as the working fluid. The heat transfer periments were conducted with two stainless steel tubes of internal diameter 4.26 mm ...
Huo, Y, Karayiannis, TG, Tian, S
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