Results 71 to 80 of about 5,240,245 (344)

Interaction of HS1BP3 with cortactin modulates TKS5 localisation, cell secretion and cancer malignancy

Molecular Oncology, EarlyView.
Here, we demonstrate that HS1BP3 interacts with Cortactin through a proline‐rich region (PRR3.1) and show that this interaction, and HS1BP3 itself, promote cancer cell proliferation and invasion. Inhibition of this interaction leads to build‐up of TKS5 in multivesicular endosomes and altered secretion of CD63 and CD9, providing an explanation for the ...
Arja Arnesen Løchen, Kristiane Søreng, Chiara Veroni, Laura Trachsel‐Moncho, Nagham Asp, Robin Gaupset, Lars Gustav Lyckander, Helene Knævelsrud, Lars Eftang, Anne Simonsen   +9 more
wiley   +1 more source

Longitudinal genome‐wide aneuploidy measurements in circulating cell‐free DNA to predict lack of benefit from pembrolizumab in patients with metastatic urothelial cancer

Molecular Oncology, EarlyView.
Many patients with urothelial cancer do not benefit from treatment with pembrolizumab, while at risk of severe side effects. Changes in the levels of circulating tumor DNA early during treatment, measured by a simple and affordable assay that can be easily implemented in the clinic, can be used as a prognostic tool to identify these patients.
Youssra Salhi, Stavros Makrodimitris, Sandra van Wilpe, Iris te Paske, Vanja de Weerd, Corine M. Beaufort, Hans M. Westgeest, Jens Voortman, Maureen J. B. Aarts, Maud Rijnders, Astrid A. M. van der Veldt, Ronald de Wit, Niven Mehra, Saskia M. Wilting, Debbie G. J. Robbrecht   +14 more
wiley   +1 more source

Flat-Plate Solar Collectors for Water Heating with Improved Heat Transfer for Application in Climatic Conditions of the Mediterranean Region [PDF]

, 2009
The aim of this research project is to improve the thermal performance of passive flat plate solar collectors using a novel cost effective enhanced heat transfer technique.
IORDANOU, GRIGORIOS
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A Multiple Response Prediction Model for Dissimilar AA-5083 and AA-6061 Friction Stir Welding Using a Combination of AMIS and Machine Learning

Computation, 2023
This study presents a methodology that combines artificial multiple intelligence systems (AMISs) and machine learning to forecast the ultimate tensile strength (UTS), maximum hardness (MH), and heat input (HI) of AA-5083 and AA-6061 friction stir welding.
Rungwasun Kraiklang, Chakat Chueadee, Ganokgarn Jirasirilerd, Worapot Sirirak, Sarayut Gonwirat   +4 more
doaj   +1 more source

MITF maintains genome stability in nonmelanocyte lineages

Molecular Oncology, EarlyView.
MITF is essential for melanocyte survival and acts as an oncogene in 10%–20% of melanomas. We show that MITF depletion causes genome instability in nonmelanocytic cells, leading to LATS2‐mediated P53 activation, cell cycle arrest, and apoptosis. This study highlights the role of MITF as a genome maintenance factor beyond the melanocyte lineage. Created
Drifa H. Gudmundsdottir, Adrián López García de Lomana, Thejus B. Venkatesh, Kritika Kirty, Snaevar Sigurdsson, Linda Vidarsdottir, Ramile Dilshat, Erla Sveinbjornsdottir, Snaedis Ragnarsdottir, Daniel H Magnusson, Maria R. Bustos, Eirikur Steingrimsson, Thorkell Gudjonsson, Stefan Sigurdsson   +13 more
wiley   +1 more source

Optimal Heat Input for Estimating Luikov's Parameters in a Heat and Mass Transfer Problem

, 2011
International audienceIn this article, the problem of computing an optimal heat input in Luikov's heat and mass transfer problem is detailed and analyzed.
Mohammed Boussaid, Tahar Loulou, Boussaid, M., Loulou, Tahar, Boussaid, Mohammed, Bensefia, Abdelmalek, Bensefia, A., Loulou, T., Abdelmalek Bensefia   +8 more
core   +1 more source

Effects of Heat Input and Backing Gas on Bead Geometry and Weld Heat Tint in Sanitary Tube Welding

Thermo
Heat input always plays a crucial role in enhancing penetration depth within the heat-affected zone (HAZ) of the orbital TIG welding process. The heat tint, in addition, caused by heat input, is a decisive factor for the quality of sanitary tube welds ...
Ngoc-Thien Tran, Van-Thuc Nguyen, Thanh Trung Do, Van-Sung Nguyen   +3 more
doaj   +1 more source

Effect of Heat Input on the Microstructural, Mechanical, and Corrosion Properties of Dissimilar Weldment of Conventional Austenitic Stainless Steel and Low-Nickel Stainless Steel

Metallography Microstructure and Analysis, 2020
In the present investigation, an attempt has been made to investigate the replacement compatibility of conventional austenitic stainless steel (316L) with low-Ni austenitic stainless steel (201) by employing their dissimilar welding using gas tungsten ...
Vipin Tandon, Manish A. Thombre, A. Patil, R. V. Taiwade, H. Vashishtha   +4 more
semanticscholar   +1 more source

Tumor B‐cell infiltration in platinum‐treated advanced muscle‐invasive urothelial carcinoma

Molecular Oncology, EarlyView.
Bladder tumors with higher pretreatment memory B‐cell infiltration were linked to longer survival after cisplatin chemotherapy, but not carboplatin. These tumors also showed more organized immune structures (tertiary lymphoid structures) and a shared pro‐inflammatory B‐cell‐rich community, suggesting that memory B cells may help identify patients most ...
Konrad Stawiski, Júlia Perera‐Bel, Alejo Rodriguez‐Vida, Nuria Juanpere, Jihyun Lee, Daniel E. Michaud, Jennifer L. Guerriero, Kent W. Mouw, Aristotelis Bamias, Filipe L. F. Carvalho, Joaquim Bellmunt   +10 more
wiley   +1 more source

Annular flow enhanced two-phase evaporative heat exchanger for space-based systems [PDF]

, 1991
The development of multi-kilowatt space-based systems requires the transport of waste heat loads over long distances in micro-gravity conditions. In this context two-phase heat transport systems are attractive enabling a high rate of heat transport ...
Nikanpour, D.
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