Results 31 to 40 of about 134,496 (302)

A novel quinazolinone insulin receptor inhibitor and its synergy with an EGFR inhibitor in glucose‐driven glioblastoma

open access: yesMolecular Oncology, EarlyView.
The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka   +9 more
wiley   +1 more source

Energy Supply System for Industrial Poultry Houses [PDF]

open access: yesProblems of the Regional Energetics, 2016
The gas engine driven carbon dioxide heat pump designed for providing the heat, cold and electricity for industrial poultry house is proposed. The scheme differs from the known by using recuperative heat exchanger installed between the exhaust air duct ...
Sit M.L.   +3 more
doaj  

Oncogenic DMTF1β promotes cancer cell motility by regulating autophagy through ULK1 stabilization

open access: yesMolecular Oncology, EarlyView.
In the current study, we demonstrate that the oncogene DMTF1β regulates ULK1 stability by reducing its proteasomal degradation in cancer cells. This stabilization enables ULK1 to induce autophagy, which in turn facilitates cancer cell migration. Consequently, reduced DMTF1β levels lead to decreased autophagy and impaired cancer cell migration.
Jun Xu   +13 more
wiley   +1 more source

Performance analysis of a secondary heat recovery solar-assisted heat pump drying system for mango

open access: yesEnergy Exploration & Exploitation, 2019
An experimental investigation of solar-assisted heat pumpa drying mango has been conducted. A new solar-assisted heat pump drying system with a secondary heat recovery was setup, which can operate independently in solar drying mode and heat pump drying ...
Yunfeng Wang   +6 more
doaj   +1 more source

Raman‐based label‐free microscopic analysis of the pancreas in living zebrafish larvae

open access: yesFEBS Open Bio, EarlyView.
Forward stimulated Raman scattering (F‐SRS) and epi coherent anti‐Stokes Raman scattering (E‐CARS) allow label‐free discrimination of distinct subcellular structures in the pancreas of living zebrafish larvae. Given the straightforward applicability, we anticipate broad implementation of Raman microscopy in other organs and across various biomedical ...
Noura Faraj   +3 more
wiley   +1 more source

Predicting in situ heat pump performance: An investigation into a single ground-source heat pump system in the context of 10 similar systems [PDF]

open access: yes, 2012
Ten similar ground-source heat pump systems installed in small rural social housing bungalows in the UK have been monitored in detail over a period of more than one year.
Lilley, D   +3 more
core   +1 more source

A light‐triggered Time‐Resolved X‐ray Solution Scattering (TR‐XSS) workflow with application to protein conformational dynamics

open access: yesFEBS Open Bio, EarlyView.
Time‐resolved X‐ray solution scattering captures how proteins change shape in real time under near‐native conditions. This article presents a practical workflow for light‐triggered TR‐XSS experiments, from data collection to structural refinement. Using a calcium‐transporting membrane protein as an example, the approach can be broadly applied to study ...
Fatemeh Sabzian‐Molaei   +3 more
wiley   +1 more source

Research on Heat Pump Seasonal Performance Factor

open access: yesZhileng xuebao, 2016
Heat pump is a machine for renewable energy recovery. Several units of renewable energy can be obtained with the consumption of one unit of electric or mechanical energy.
Ma Yitai, Dai Baomin
doaj   +2 more sources

On the Design and Response of Domestic Ground-Source Heat Pumps in the UK

open access: yes, 2014
The design and response of ground source heat pumps coupled to vertical closed loop arrays in UK domestic applications are investigated in this article.
Underwood, Chris, Chris Underwood
core   +1 more source

Single‐molecule DNA flow‐stretch assays for high‐throughput DNA–protein interaction studies

open access: yesFEBS Open Bio, EarlyView.
We describe an optimised single‐molecule DNA flow‐stretch assay that visualises DNA–protein interactions in real time. Linear DNA fragments are tethered to a surface and stretched by buffer flow for fluorescence imaging. Using λ and φX174 DNA, this protocol enhances reproducibility and accessibility, providing a versatile approach for studying diverse ...
Ayush Kumar Ganguli   +8 more
wiley   +1 more source

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