Results 91 to 100 of about 11,123,934 (324)

Nucleoside‐Modified mRNA Encoding Alpha‐Galactosidase A Ameliorates Fabry Disease Phenotypes in Human IPSC‐Derived Cardiomyocytes

Advanced Science, EarlyView.
Human iPSC‐derived Fabry cardiomyocytes exhibited broad transcriptional dysregulation, apoptosis, mitochondrial dysfunction, impaired reactive oxygen species handling, altered contractility, and abnormal calcium transient decay, potentially mediated by phospholamban hyperphosphorylation.
Malte Juchem, Lea Oehlsen, Sedef Ersoy, Jia Li Ye, Natalie Weber, Elisa Mohr, Wilson Agyapong, Junqing Liu, Maximilian Fuchs, Ke Xiao, Christopher Jahn, Reto Eggenschwiler, Tobias Cantz, Julia Beimdiek, Falk F. R. Buettner, Theresia Kraft, Jan Hegermann, Ivonne J. Knorr, Lisa Ernst, Linda Feldbrügge, Resa Puffert, Kevin Schmidt, Christian Bär, Jeannine Hoepfner, Thomas Thum   +24 more
wiley   +1 more source

Risk perceptions of heat-related illnesses, assessing vulnerability, and adaptive capacity of brickkiln workers in a rural Puducherry: A cross-sectional study

Indian Journal of Community and Family Medicine
Introduction: One of the physical risks that may lead to health issues at work is heat; brickkiln workers are often exposed to conditions that increase their risk of developing heat-related illnesses (HRIs).
Iswarya Ramakrishnan, Rajini Senthil, S. Pravinraj, Premnath Dhasaram, Monisha Venkatesan, T. Manjubairavi, Sheeba Ravi   +6 more
doaj   +1 more source

Evaluation of a Novel Syndromic Surveillance Query for Heat-Related Illness Using Hospital Data From Maricopa County, Arizona, 2015

, 2017
Objectives: We evaluated a novel syndromic surveillance query, developed by the Council of State and Territorial Epidemiologists (CSTE) Heat Syndrome Workgroup, for identifying heat-related illness cases in near real time, using emergency department and ...
Jessica R. White, Vjollca Berisha, Kathryn Lane, Carol R. Braun, Henri Ménager, Aaron Gettel   +5 more
core   +1 more source

Heat related illness in palm oil mill workers under heat stress [PDF]

, 2014
Background: Occupational heat stress is a one of the major issues in tropical countries such as Malaysia which affects workers' health and performance.
Mohd Tamrin, Shamsul Bahri, Mohammad Yusof, Nur Athirah Diyana, Karuppiah, Karmegam   +2 more
core   +1 more source

Relationships between maximum temperature and heat-related illness across North Carolina, USA [PDF]

, 2016
Heat kills more people than any other weather-related event in the USA, resulting in hundreds of fatalities each year. In North Carolina, heat-related illness accounts for over 2,000 yearly emergency department admissions.
Sugg, Margaret M., Fuhrmann, Christopher M., Konrad, Charles E.   +2 more
core   +1 more source

Disease‐Stage Synchronized Nanozyme Therapy for Polymicrobial Sepsis through Adaptive Catalytic and Immune Reprogramming

Advanced Science, EarlyView.
A disease‐stage synchronized nanozyme platform is developed to treat polymicrobial sepsis by adapting its functions to changing infection environments. The system eliminates multidrug‐resistant bacteria during early infection while reducing inflammation and restoring immune balance during recovery, providing an integrated strategy for infection control
Anlai Zou, Xiaoxue Zhu, Runhan Zhu, Chengchu Xue, Qinyu Zhang, Mengke Li, Ting Yu, Yuzhen Gao, Zhi Ruan, Ying Fu, Yunlei Xianyu, Jun Zhang   +11 more
wiley   +1 more source

Workers’ perceptions of climate change related extreme heat exposure in South Australia: a cross-sectional survey

BMC Public Health, 2016
Background Occupational exposure to extreme heat without sufficient protection may not only increase the risk of heat-related illnesses and injuries but also compromise economic productivity.
Jianjun Xiang, Alana Hansen, Dino Pisaniello, Peng Bi   +3 more
doaj   +1 more source

Heat-Related Illness versus All Hospitalizations Rates, Summer 2001–2010.

, 2016
The dotted line represents the rate of all hospitalizations during the study time period which remained approximately level over time. The solid line represents heat-related illness hospitalizations which although varied by year have steadily increased ...
Peter J. Marcotullio (2216752), Jean A. Grassman (2216758), Michael T. Schmeltz (2216761), Stephanie Woolhandler (2216764), Grace Sembajwe (2216755), David U. Himmelstein (392244)   +5 more
core   +1 more source

Macrophage RSAD2 Couples mtDNA Synthesis With a Self‐Amplifying Inflammatory Circuit to Orchestrate Tissue Repair

Advanced Science, EarlyView.
Macrophage RSAD2 dually regulates CMPK2—the rate‐limiting enzyme for mitochondrial DNA synthesis—by suppressing its ubiquitination and promoting its phosphorylation via Csnk2a2 recruitment. This amplifies mtDNA production, which simultaneously activates a cGAS‐STING‐IRF3‐RSAD2 feedforward loop and the NLRP3 inflammasome, driving a self‐sustaining ...
Haomiao Yuan, Shukui Du, Chunfei Li, Xinjie Li, Shuyang Mu, Anran Qu, Hengxu Yan, Chongchong Xu, Jinnong Yang, Jingkai Sun, Yijun Wang, Jiayang Xiao, Fuyuan Zhang, Linlin Wang, Tiegang Li, Rui Zhao, Dawei Guan   +16 more
wiley   +1 more source

Heat stress Regulations and standards: The key to preventing heat-related illness

طب کار, 2017
Introduction: One ways to prevent heat stress illness and protect workers is regional and national legislation and international standards about heat stress.
Mehdi Asghari, Parvin Nassiri, Mohammadreza Monazzam, Farideh Golbabaei, Marzieh Abbasinia, Masoumeh Chavoshi   +5 more
doaj