Results 101 to 110 of about 844,270 (306)

PARP inhibitors elicit distinct transcriptional programs in homologous recombination competent castration‐resistant prostate cancer

Molecular Oncology, EarlyView.
PARP inhibitors are used to treat a small subset of prostate cancer patients. These studies reveal that PARP1 activity and expression are different between European American and African American prostate cancer tissue samples. Additionally, different PARP inhibitors cause unique and overlapping transcriptional changes, notably, p53 pathway upregulation.
Moriah L. Cunningham, Jasibel Vasquez‐Gonzalez, Samantha M. Barnada, Salome Tchotorlishvili, Latese Jones, Ryan Maguire, Genevieve Lewis, Kinza Rizwan, Jenny Deng, Salma Koachar, Drithi Patel, Hailey Shankle, Tessa Mulders, Namra Ajmal, Charalambos Solomides, Emad S. Alnemri, Teresa F. Alnemri, Ayesha A. Shafi, Leonard G. Gomella, Wm Kevin Kelly, Steven B. McMahon, Matthew J. Schiewer   +21 more
wiley   +1 more source

Absorbed Heat-flux Method for Ground Simulation of On-orbit Thermal Environment of Satellite [PDF]

Journal of Astronomy and Space Sciences, 1999
An absorbed heat-flux method for ground simulation of on-orbit thermal environment of satellite is addressed in this paper. For satellite ground test, high vacuum and extremely low temperature of deep space are achieved by space simulation chamber, while
Jeong-Soo Kim, Young-Keun Chang
doaj  

Heat transfer and pressure drop in blade cooling channels with turbulence promoters [PDF]

Repeated rib roughness elements have been used in advanced turbine cooling designs to enhance the internal heat transfer. Often the ribs are perpendicular to the main flow direction so that they have an angle-of-attack of 90 deg.
Han, J. C., Lei, C. K., Park, J. S.
core   +1 more source

Time and temperature requirements for heat inactivation of pathogens to be applied to swine transport trailers [PDF]

, 2021
Jill van Kessel, Stacy Strom, Hans Deason, Elaine Van Moorlehem, Nathalie G. Bérubé, Shirley Hauta, C. Kekulu Fernando, Janet M. Hill, Terrance A. Fonstad, Volker Gerdts   +9 more
openalex   +1 more source

Adenosine‐to‐inosine editing of miR‐200b‐3p is associated with the progression of high‐grade serous ovarian cancer

Molecular Oncology, EarlyView.
A‐to‐I editing of miRNAs, particularly miR‐200b‐3p, contributes to HGSOC progression by enhancing cancer cell proliferation, migration and 3D growth. The edited form is linked to poorer patient survival and the identification of novel molecular targets.
Magdalena Niemira, Anna Skwarska, Karolina Chwialkowska, Agnieszka Ostrowska, Gabriela Sokolowska, Anna Zeller, Anna Erol, Andrzej Eljaszewicz, Bartosz Hanczaruk, Anna Michalska‐Falkowska, Agnieszka Tarasik, Joanna Reszec‐Gielazyn, Pawel Knapp, Marcin Moniuszko, Adam Kretowski   +14 more
wiley   +1 more source

Thermal Requirements and Heat Use Efficiency of Pea Cultivars under Varying Environments [PDF]

, 2019
Savita Devi, Mohan Singh, R. K. Aggarwal
openalex   +1 more source

Multi‐omic profiling of squamous cell lung cancer identifies metabolites and related genes associated with squamous cell carcinoma

Molecular Oncology, EarlyView.
Using multi‐omic characterization, we aimed to identify key regulators specific to squamous cell lung carcinoma (SqCC). SqCC‐specific differentially expressed genes were integrated with metabolics data. High expression of the creatine transporter SLC6A8, along with elevated creatine levels, appeared to be a distinct metabolic feature of SqCC.
Johan Staaf, Daniel Ehinger, Hans Brunnström, Mats Jönsson, Frida Rosengren, Marija Kotevska, Anna Karlsson, Mattias Aine, Christian Frezza, Maria Planck, Elsa Arbajian   +10 more
wiley   +1 more source

Unified Gas-kinetic Wave-Particle Methods II: Multiscale Simulation on Unstructured Mesh

, 2019
In this paper, we present a unified gas-kinetic wave-particle (UGKWP) method on unstructured mesh for multiscale simulation of continuum and rarefied flow.
Aristov V. V., Bird G. A., Gallis M., Shen C., Wadsworth D., Xu K.   +5 more
core   +1 more source

Differential MyD88/IRAK4 requirements for cross‐priming and tumor rejection induced by heat shock protein 70‐model antigen fusion protein [PDF]

, 2012
Shusaku Mizukami, Chiaki Kajiwara, Masato Tanaka, Tsuneyasu Kaisho, Heiichiro Udono   +4 more
openalex   +1 more source

Predictors of response and rational combinations for the novel MCL‐1 inhibitor MIK665 in acute myeloid leukemia

Molecular Oncology, EarlyView.
This study characterizes the responses of primary acute myeloid leukemia (AML) patient samples to the MCL‐1 inhibitor MIK665. The results revealed that monocytic differentiation is associated with MIK665 sensitivity. Conversely, elevated ABCB1 expression is a potential biomarker of resistance to the treatment, which can be overcome by the combination ...
Joseph Saad, Rhiannon Newman, Elmira Khabusheva, Sofia Aakko, Eric Durand, Mahesh Tambe, Heikki Kuusanmäki, Alun Parsons, Juho J. Miettinen, Komal Kumar Javarappa, Ezgi June Olgac, Nemo Ikonen, Mika Kontro, Kimmo Porkka, Heiko Maacke, Janghee Woo, Ensar Halilovic, Caroline A. Heckman   +17 more
wiley   +1 more source