Results 61 to 70 of about 173,029 (259)

Performance Analysis and Working Fluid Selection of a Supercritical Organic Rankine Cycle for Low Grade Waste Heat Recovery

Energies, 2012
The performance analysis of a supercritical organic Rankine cycle system driven by exhaust heat using 18 organic working fluids is presented. Several parameters, such as the net power output, exergy efficiency, expander size parameter (<em>SP< ...
Yourong Li, Shuangying Wu, Xiaoxiao Xu, Chao He, Chao Liu, Hong Gao   +5 more
doaj   +1 more source

Mixed‐class J‐domain protein scaffolds promote expanded aggregate handling and multivalent Hsp70 engagement during functional disaggregase assembly

FEBS Letters, EarlyView.
Protein aggregates threaten proteostasis and cell health. In human cells, Hsp70–J‐domain protein‐based disaggregases remove aggregates, but how they assemble remains unclear. Our biochemical findings show that DNAJA2‐ and DNAJB1‐containing disaggregase scaffolds enhance luciferase aggregate targeting, and that Hsp70 recruitment by both J‐domain ...
Anna Szlachcic, Nadinath B. Nillegoda
wiley   +1 more source

TRAIL‐PEG‐Apt‐PLGA nanosystem as an aptamer‐targeted drug delivery system potential for triple‐negative breast cancer therapy using in vivo mouse model

Molecular Oncology, EarlyView.
Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat, Aslihan Kucuk, Omer Erdogan, Samed Ozer, Bensu Kozan, Tugba Cuceli, Erkan Gumus, Evrim Cevik, Ozge Cevik   +8 more
wiley   +1 more source

Testing Greenhouse Heat Requirement Calculation Model “ISIGER-SERA” in Cukurova Conditions

, 2018
Serada ısı gereksinimi, seranın tipine, donanımına, sera kurulacak yerin iklimine ve bitkilerin arzu ettiği sıcaklığa bağlıdır ve DIN EN 13032 (Eskiden DIN 4701) standartlarında belirtilen esaslara göre hesaplanmaktadır.
Sait Üstün, Ali ÇAYLI, A Nafi Baytorun, A. Nafi BAYTORUN, Baytorun, A. Nafi, Ali Çaylı, Ustun, Sait, Akyuz, Adil, Adil Akyüz, Cayli, Ali   +9 more
core   +1 more source

The relationship between absolute evaporative requirement for heat balance (Ė_req) and measures of the sweating response.

, 2022
The relationship between absolute evaporative requirement for heat balance (Ėreq) and measures of the sweating response.
Mark Waldron (9660368), Shane M. Heffernan (14204776), Melitta A. McNarry (3180384), Liam P. Kilduff (12066120), Jennifer S. Peel (14204773), Venturino R. Nevola (14204779)   +5 more
core   +1 more source

Engineered extracellular vesicles enriched with the miR‐214/199a cluster enhance the efficacy of chemotherapy in ovarian cancer

Molecular Oncology, EarlyView.
Loss of the miR‐214/199a cluster is associated with recurrence in ovarian cancer. Engineered small extracellular vesicles (m214‐sEVs) elevate miR‐214‐3p/miR‐199a‐5p in tumor cells, suppress β‐catenin, TLR4, and YKT6 signaling, reprogram tumor‐derived sEV cargo, reduce chemoresistance and migration, and enhance carboplatin efficacy and survival in ...
Weida Wang, Ayesha Alvero, Yi Qin, Mingjin Wang, Alexandra Fox, Yanfeng Li, Michael Millman, Amy Kemper, Gil Mor, Xian Shuang Liu, Michael Chopp, Zheng Gang Zhang, Yi Zhang   +12 more
wiley   +1 more source

Technology assessment: technology viable to keep "take-home" food warm for 30 minutes

, 2003
Plan BVarious technologies are reviewed for appropriateness of packaging technology to retain heat within a take-home package. Technologies explored include insulation materials, Phase Change Materials (PCM), induction heating, non-chemical heat sources,
Anderson, Neal
core  

A framework for adaptation of Australian households to heat waves [PDF]

, 2013
Climate change is leading to an increased frequency and severity of heat waves. Spells of several consecutive days of unusually high temperatures have led to increased mortality rates for the more vulnerable in the community. The problem is compounded by
John Boland, Stephen Pullen, Wasim Saman
core  

IMPDH inhibition enhances cytarabine efficacy in SAMHD1‐expressing leukaemia cells via guanine nucleotide depletion

Molecular Oncology, EarlyView.
Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla, Christopher Dirks, Caroline Eiden, Sonja K. Fesenmayer, Femke M. Hormann, Yolande Klootsema, Ingrid Lilienthal, Si Min Zhang, Nikolas Herold, Sean G. Rudd   +9 more
wiley   +1 more source

Dual PI3K/AKT and CDK4/6 inhibition reveals selective sensitivity in an SHH medulloblastoma stem cell model

Molecular Oncology, EarlyView.
Targeted therapy was evaluated in SHH medulloblastoma using neuroepithelial stem cell (NES) and tumor‐derived NES‐like (tNES) models in 2D monolayers and 3D spheroids. PI3K, AKT, and CDK4/6 inhibitors had minimal effects in NES but markedly reduced viability and growth and induced apoptosis in tNES cells, revealing distinct therapeutic vulnerabilities.
Monika Lukoseviciute, Madeleine Birgersson, Paolo Ceriani, Margareta Wilhelm, Ourania N Kostopoulou   +4 more
wiley   +1 more source