Results 111 to 120 of about 171,704 (286)

Covalent Inhibition of SHMT2 by Gambogic Acid Induces Ferroptosis Through Mitochondrial Collapse in Triple‐Negative Breast Cancer

Advanced Science, EarlyView.
In this study, chemoproteomics combined with genetic and functional analyses was integrated to identify SHMT2 as a covalent and functional target of gambogic acid (GA) in triple‐negative breast cancer (TNBC). Further validation demonstrated that GA selectively modifies the Cys241 site of SHMT2, triggering mitochondrial dysfunction, activating the Nrf2 ...
Tong Yang, Chong Qiu, Yulei Li, Ying Zhang, Chen Wang, Jie Zhou, Zheng Chu, Ang Ma, Ling Huang, Yin Kwan Wong, Junzhe Zhang, Peng Gao, Cui Liu, Junhua Zhang, Huan Tang, Jigang Wang   +15 more
wiley   +1 more source

Evaluation of Circulatory and Salivary Levels of Heat Shock Protein 60 in Periodontal Health and Disease [PDF]

, 2011
BACKGROUND: Self antigens such as Heat shock protein 60 (HSP 60) have recently been implicated in the periodontal disease pathogenesis. There is scant evidence regarding HSP 60 in circulation and saliva following periodontal disease and its possible ...
Ramya Nethravathy, R
core  

Detection of antihuman HSP60 antibody in patients with type 1 diabetes

Majallah-i Dānishgāh-i ̒Ulūm-i Pizishkī-i Bābul, 2003
Background and Objective: Type I diabetes is a chronic disorder of pancreas. This disorder occurs as a result of autoimmune destruction of insulin producing beta-cells. Long duration before the onset of clinical symptoms, the autoimmune reactions develop.
A Mostafa Zadeh, MB Eslami, N Schloot, P Hanifi Moghaddam, H Kolb   +4 more
doaj  

Disruption of Treg Homeostasis in Rheumatoid Arthritis via Ferroptosis‐Mediated ETC Collapse and TXK‐STAT3/PLCγ1 Activation

Advanced Science, EarlyView.
In rheumatoid arthritis, synovial Tregs accumulate but are functionally impaired due to iron overload‐induced ferroptosis. This triggers mitochondrial dysfunction and TXK tyrosine kinase‐mediated signaling, leading to Treg destabilization and inflammation.
Jingrong Chen, Xiao Guan, Kexu Xiong, Xiaoyi Shi, Luyao Wu, Chuanxin Su, Jun Zhao, Rongzhen Liang, Huimin Wang, Junlong Dang, Ye Chen, Yiding Xiong, Chi Zhou, Futao Zhao, Zhenhang Zhu, Xiaoli Fan, Li Zhou, Nancy Olsen, Yutong Jiang, Song Guo Zheng   +19 more
wiley   +1 more source

A Potential Role for Helicobacter Pylori Heat Shock Protein 60 in Gastric Tumorigenesis

, 2011
Helicobacter pylon has been found to promote the malignant process leading to gastric cancer. Heat shock protein 60 of H. pylori (HpHSP60) was previously been identified as a potent immunogene.
林辰栖;蔡女滿;楊上知;吳明賢;吳彰哲;鄭添祿;廖光文, LIN, CHEN-SI;TSAI, NU-MAN;YANG, SHANG-CHIH;WU, MING-SHIANG;WU, CHANG-JER;CHENG, TIAN-LU;LIAO, KUANG-WEN   +1 more
core   +1 more source

Redox‐Dependent Chaperoning of GBF1 Condensates Regulates Seed Germination in Arabidopsis

Advanced Science, EarlyView.
In dormant seeds (low ROS), GBF1 forms liquid condensates to repress the germination gene CathB3, and the chaperone GIP1 maintains condensate liquidity and repressive activity. Upon imbibition (high ROS), ROS oxidize GIP1 during germination, impairing its chaperone function.
Yunying Wang, Xiaofeng Fang
wiley   +1 more source

Cloning, molecular analysis and epitopics prediction of a new chaperone GroEL Brucella melitensis antigen [PDF]

Iranian Journal of Basic Medical Sciences, 2015
Objective(s):Brucellosis is a well-known domestic animal infectious disease, which is caused by Brucella bacterium. GroEL antigen increases Brucella survival and is one of the major antigens that stimulates the immune system.
Mohammad Hadi Sekhavati, Reza Majidzadeh Heravi, Mojtaba Tahmoorespur, Soheil Yousefi, Tooba Abbassi-Daloii, Rahebe Akbari   +5 more
doaj  

FGF13 Deficiency Ameliorates Paclitaxel‐Induced Neuropathic Pain by Inhibiting VASH1‐Mediated Microtubule Detyrosination to Promote Mitophagy

Advanced Science, EarlyView.
FGF13 is upregulated in DRG neurons of PIPNP model mice. DRG neuron‐specific knockout of FGF13 ameliorates PIPNP symptoms. Mechanistically, FGF13 potentiates microtubule detyrosination by promoting VASH1 binding to microtubules. FGF13 knockout suppresses VASH1‐mediated microtubule detyrosination and promotes α‐tubulin tyrosination.
Yiming Dong, Yidan Wang, Simeng Lv, Zishan Dong, Kaixi Zhi, Xiuhua Guo, Xuyan Li, Ruoxi Yu, Yiyi Zhang, Siyuan Cheng, Chuan Wang   +10 more
wiley   +1 more source

The role of heat shock protein-60 in vascular smooth muscle cell proliferation and atherosclerotic development

, 2017
This study investigated whether heat shock protein-60 (Hsp60) modulates nuclear protein import (NPI) to promote vascular smooth muscle cell (VSMC) proliferation and atherosclerotic development.
Hedley, Thomas Elliot
core  

Anti-heat shock protein 60 autoantibodies induce atherosclerosis in apolipoprotein E-deficient mice via endothelial damage

, 2005
Accumulating evidence established a positive association of anti-heat shock protein 60 (HSP60) autoantibodies and the presence of atherosclerosis in humans. However, whether these autoantibodies play a causal role in the development of atherosclerosis is
Mandal, K, Afzal, AR, Xu, Q, Foteinos, G, Jahangiri, M   +4 more
core   +1 more source