Results 1 to 10 of about 39,670 (208)

HSP60, Bax, Apoptosis and the Heart [PDF]

Journal of Cellular and Molecular Medicine, 2005
HSP60 has primarily been known as a mitochondrial protein that is important for folding key proteins after import into the mitochondria. It is now clear that a significant amount of HSP60 is also present in the extra-mitochondrial cytosol of many cells. In the heart, this cytosolic HSP60 complexes with Bax, Bak and Bcl-XL, but not with Bcl-2. Reduction
A A Knowlton
exaly   +3 more sources

HSP60 chaperone deficiency disrupts the mitochondrial matrix proteome and dysregulates cholesterol synthesis

Molecular Metabolism
Objective: Mitochondrial proteostasis is critical for cellular function. The molecular chaperone HSP60 is essential for cell function and dysregulation of HSP60 expression has been implicated in cancer and diabetes.
P Bross
exaly   +3 more sources

Aberrant mitochondrial hsp60 expression affects mitochondria homeostasis and results in muscle dystrophy and premature death [PDF]

Cell Death and Disease
Heat shock protein 60 (HSP60) plays a vital role in maintaining mitochondrial homeostasis and essential functions and requires ATP for its assembly into chaperone complexes.
Tsung-Hsien Chen, Chu-Kuang Chou, Kurt Ming-Chao Lin   +2 more
doaj   +2 more sources

HSP60 silencing promotes Warburg-like phenotypes and switches the mitochondrial function from ATP production to biosynthesis in ccRCC cells

Redox Biology, 2019
HSP60 is a major mitochondrial chaperone for maintaining mitochondrial proteostasis. Our previous studies showed that HSP60 was significantly downregulated in clear cell renal cell carcinoma (ccRCC), the most common type of kidney cancer characterized by
Haiping Tang, Wenhao Zhang, Yuling Chen   +2 more
exaly   +3 more sources

Doxorubicin anti-tumor mechanisms include Hsp60 post-translational modifications leading to the Hsp60/p53 complex dissociation and instauration of replicative senescence [PDF]

Cancer Letters, 2017
The chaperone Hsp60 is pro-carcinogenic in certain tumor types by interfering with apoptosis and with tumor cell death. In these tumors, it is not yet known whether doxorubicin anti-tumor effects include a blockage of the pro-carcinogenic action of Hsp60.
Rosario Barone, Celeste Caruso Bavisotto, Magdalena Górska   +2 more
exaly   +4 more sources

HSP60: Issues and Insights on Its Therapeutic Use as an Immunoregulatory Agent

Frontiers in Immunology, 2012
HSP60 is one of the most well studied member of the HSP family. Although found to be a target self antigen in pathological autoimmunity and HSP60-reactive T and B cells are part of immune responses in several infectious diseases, there is consistent ...
Veronica Coelho, Ana M C Faria
exaly   +3 more sources

Wide Distribution and Specific Resistance Pattern to Third-Generation Cephalosporins of Enterobacter cloacae Complex Members in Humans and in the Environment in Guadeloupe (French West Indies)

Frontiers in Microbiology, 2021
Species belonging to Enterobacter cloacae complex have been isolated in numerous environments and samples of various origins. They are also involved in opportunistic infections in plants, animals, and humans.
Matthieu Pot, Yann Reynaud, David Couvin, Célia Ducat, Séverine Ferdinand, François Gravey, Gaëlle Gruel, François Guérin, François Guérin, Edith Malpote, Sébastien Breurec, Sébastien Breurec, Sébastien Breurec, Antoine Talarmin, Stéphanie Guyomard-Rabenirina   +14 more
doaj   +1 more source

HSP60 reduction protects against diet-induced obesity by modulating energy metabolism in adipose tissue

Molecular Metabolism, 2021
Objective: Insulin regulates mitochondrial function, thereby propagating an efficient metabolism. Conversely, diabetes and insulin resistance are linked to mitochondrial dysfunction with a decreased expression of the mitochondrial chaperone HSP60.
Robert Hauffe, Michaela Rath, Mareike Schell, Katrin Ritter, Kai Kappert, Stefanie Deubel, Christiane Ott, Markus Jähnert, Wenke Jonas, Annette Schürmann, André Kleinridders   +10 more
doaj   +1 more source

HSP60 as a target of anti-ergotypic regulatory T cells. [PDF]

PLoS ONE, 2008
The 60 kDa heat shock protein (HSP60) has been reported to influence T-cell responses in two ways: as a ligand of toll-like receptor 2 signalling and as an antigen.
Francisco J Quintana, Avishai Mimran, Pnina Carmi, Felix Mor, Irun R Cohen   +4 more
doaj   +1 more source

Heat shock protein 60 expression and localisation in different tissues and testis development of male cattle (cattle-yak and yak)

Folia Morphologica, 2021
BACKGROUND: Heat shock protein 60 (Hsp60) play important roles in protecting testicular development and production of sperms. This study was conducted to investigate Hsp60 gene expression and localisation in testicular development to ascertain its ...
S. Zou, P. Liu, S. Yu, Y. Cui, J. He, S. Y. Afedo, H. Zhang, R. Niayale, K. Zhao   +8 more
doaj   +1 more source