Results 11 to 20 of about 26,329 (222)
Conserved HSP60 structure with lineage- and context-specific regulation in cnidarians [PDF]
Life Science AllianceHSP60 regulation varies across three cnidarians ( P. acuta, E. diaphana, C. xamachana ). Cross-reactive antibodies and evolutionary analyses confirm orthology with human HSP60, highlighting lineage- and context-dependent regulation underlying cnidarian ...
Saborni Chowdhury +2 more
doaj +2 more sources
Drug Target Insights, 2013 Mitochondrial functions play a central role in energy metabolism and provide survival fitness to both normal and tumor cells. Mitochondrial chaperonin Hsp60 is involved in both pro- and anti-apoptotic functions, but how Hsp60 senses the mitochondria ...
Upasana Sarangi +7 more
doaj +2 more sources
HSP60 as a target of anti-ergotypic regulatory T cells. [PDF]
PLoS ONE, 2008 The 60 kDa heat shock protein (HSP60) has been reported to influence T-cell responses in two ways: as a ligand of toll-like receptor 2 signalling and as an antigen.
Francisco J Quintana +4 more
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Hsp60 regulation of tumor cell apoptosis [PDF]
Journal of Biological Chemistry, 2014 Molecular chaperones may promote cell survival, but how this process is regulated, especially in cancer, is not well understood. Using high throughput proteomics screening, we identified the cell cycle regulator and apoptosis inhibitor survivin as a ...
Altieri, Dario C. +3 more
core +5 more sources
Molecular MetabolismObjective: Mitochondrial proteostasis is critical for cellular function. The molecular chaperone HSP60 is essential for cell function and dysregulation of HSP60 expression has been implicated in cancer and diabetes.
Elsebet Østergaard, P Bross
exaly +3 more sources
Redox Biology, 2019 HSP60 is a major mitochondrial chaperone for maintaining mitochondrial proteostasis. Our previous studies showed that HSP60 was significantly downregulated in clear cell renal cell carcinoma (ccRCC), the most common type of kidney cancer characterized by
Haiping Tang +2 more
exaly +3 more sources
Hsp60 involvement during carcinogenesis
, 2019 The implication of Hsp60 in cancer development is due to its participation in many metabolic and biomolecular mechanisms in cancer cells. Hsp60 interacts with various molecules that are responsible of apoptosis, cell proliferation and other mechanisms
Francesco Carini +2 more
core +2 more sources
Aberrant mitochondrial hsp60 expression affects mitochondria homeostasis and results in muscle dystrophy and premature death [PDF]
Cell Death and DiseaseHeat shock protein 60 (HSP60) plays a vital role in maintaining mitochondrial homeostasis and essential functions and requires ATP for its assembly into chaperone complexes.
Tsung-Hsien Chen +2 more
doaj +2 more sources
Hsp60 emerges as a multifaceted player in cancer development, participating in various biochemical and metabolic pathways within cancer cells. Its participation in key processes such as apoptosis, cell proliferation, and immune modulation contributes to ...
Rappa F. +4 more
core +2 more sources
HSP60: Issues and Insights on Its Therapeutic Use as an Immunoregulatory Agent
Frontiers in Immunology, 2012 HSP60 is one of the most well studied member of the HSP family. Although found to be a target self antigen in pathological autoimmunity and HSP60-reactive T and B cells are part of immune responses in several infectious diseases, there is consistent ...
Veronica Coelho +2 more
exaly +3 more sources