Results 41 to 50 of about 26,329 (222)

High expression of HSP60 and survivin predicts poor prognosis for oral squamous cell carcinoma patients

BMC Oral Health, 2023
Background HSP60 is a heat shock proteins (HSPs) family member and help mitochondrial protein to fold correctly. Survivin is one of the inhibitors of apoptosis protein family member, which plays a significant part in cancer progression. They were capable
Ying Zhou, Yaoxiang Tang, Jiadi Luo, Yang Yang, Hongjing Zang, Jian Ma, Songqing Fan, Qiuyuan Wen   +7 more
doaj   +1 more source

A mitochondrial unfolded protein response inhibitor suppresses prostate cancer growth in mice via HSP60

The Journal of Clinical Investigation, 2022
Mitochondrial proteostasis, regulated by the mitochondrial unfolded protein response (UPRmt), is crucial for maintenance of cellular functions and survival. Elevated oxidative and proteotoxic stress in mitochondria must be attenuated by the activation of
Rahul Kumar, Ajay K. Chaudhary, Jordan Woytash, Joseph R. Inigo, Abhiram A. Gokhale, Wiam Bshara, Kristopher Attwood, Jianmin Wang, Joseph A. Spernyak, Eva Rath, Neelu Yadav, Dirk Haller, David W. Goodrich, Dean G. Tang, Dhyan Chandra   +14 more
doaj   +1 more source

Cord blood CD4+ T cells respond to self heat shock protein 60 (HSP60). [PDF]

PLoS ONE, 2011
BACKGROUND: To prevent harmful autoimmunity most immune responses to self proteins are controlled by central and peripheral tolerance. T cells specific for a limited set of self-proteins such as human heat shock protein 60 (HSP60) may contribute to ...
Joost A Aalberse, Berber Kapitein, Sytze de Roock, Mark R Klein, Wilco de Jager, Ruurd van der Zee, Maarten O Hoekstra, Femke van Wijk, Berent J Prakken   +8 more
doaj   +1 more source

The Hsp70 and Hsp60 Chaperone Machines

Cell, 1998
B. B. thanks members of his lab and J. Reinstein for critical reading of the manuscript and C. Gassler, T. Laufen, and S. Rudiger for figure preparation. A. H. thanks Wayne Fenton for critical reading and Zhaohui Xu for figure preparation. A. H. dedicates this work to Guenter Brueckner, always an inspiration.
Bukau, Bernd, Horwich, Arthur L
openaire   +3 more sources

HSP60 inhibits DF-1 apoptosis through its mitochondrial signal peptide

Poultry Science
HSP60 is implicated in many biological functions and plays a key role in maintaining oxidative stress and preserving mitochondrial integrity. Our previous study showed that HSP60 inhibits apoptosis. In this study, we further investigated the mechanism of
Shengliang Cao, Yanlan Li, Lele Chen, Xiaojing Lei, Xiujuan Feng, Yubao Li   +5 more
doaj   +1 more source

Heat shock protein 60 overexpression is associated with the progression and prognosis in gastric cancer. [PDF]

PLoS ONE, 2014
Heat shock protein 60 (HSP60) is a chaperonin with essential functions for cell physiology and survival, and its expression correlates with prognosis in a number of malignancies. The aim of this study is to determine the relationship of HSP60 status with
Xiao-shan Li, Qing Xu, Xiang-yang Fu, Wei-sheng Luo   +3 more
doaj   +1 more source

Chlamydophila abortus Pelvic Inflammatory Disease

Emerging Infectious Diseases, 2003
We report the first documented case of an extragestational infection with Chlamydophila abortus in humans. The pathogen was identified in a patient with severe pelvic inflammatory disease (PID) by sequence analysis of the ompA gene.
Gernot Walder, Herwig Meusburger, Helmut Hotzel, Albrecht Oehme, Walter Neunteufel, Manfred P. Dierich, Reinhard Würzner   +6 more
doaj   +1 more source

Studi Pilot: Peran Heat Shock Protein 60 (Hsp60) dan Kontrol Metabolik terhadap Infeksi Tuberkulosis pada Anak dan Remaja dengan Diabetes Mellitus Tipe-1

Sari Pediatri, 2019
Latar belakang. Heat shock protein 60 (Hsp60) ditemukan pada individu dengan Diabetes Mellitus (DM) tipe-1 dan merupakan mimikri molecular Hsp65 pada mycobacterium.
Aman Bhakti Pulungan, Karina Sugih Arto, Nastiti Kaswandani   +2 more
doaj   +1 more source

Differential regulation of circulating levels of molecular chaperones in patients undergoing treatment for periodontal disease. [PDF]

, 2007
Evidence is emerging that molecular chaperones, in addition to their intracellular protein folding actions, can act as intercellular signaling proteins with an ability to modulate leukocyte function. Recent evidence has also shown that these proteins can
Alireza Shamaei-Tousi, Francesco D'Aiuto, D'Aiuto Francesco, D'Aiuto, F, Coates, ARM, Henderson Brian, Henderson, B, Donos, N, Brian Henderson, Shamaei-Tousi Alireza, Coates, AR, Nibali Luigi, Coates Anthony R. M., Donos Nikos, Mohamed Parkar, Nibali, L, Parkar, M, Parkar Mohamed, Luigi Nibali, Andrew Steptoe, Anthony R M Coates, Steptoe Andrew, Steptoe, A, Shamaei-Tousi, A, Nikos Donos   +24 more
core   +1 more source

Turning Unpredictable Biomolecule Adsorption to Controlled Corona Formation: Focus on Carbon Nanomaterials

Advanced Materials, EarlyView.
Controlling the protein corona formation onto carbon nanomaterials (CNMs) enhances their functionalities as platforms for cancer theranostics. Here, we reviewed the effects of the intrinsic and acquired properties of CNMs on protein corona formation, the consequent biological and toxicological outcomes, and the strategies to reshape corona formation ...
Yajuan Zou, Yalei Hu, Jie Yu, Naoki Komatsu, Yuta Nishina, Alberto Bianco   +5 more
wiley   +1 more source