Results 31 to 40 of about 39,699 (235)

Disease-associated mutations in the HSPD1 gene encoding the large subunit of the mitochondrial HSP60/HSP10 chaperonin complex

Frontiers in Molecular Biosciences, 2016
Heat shock protein 60 (HSP60) forms together with heat shock protein 10 (HSP10) double-barrel chaperonin complexes that are essential for folding to the native state of proteins in the mitochondrial matrix space.
Peter Bross, Paula Fernandez-Guerra
doaj   +1 more source

High expression of HSP60 and survivin predicts poor prognosis for oral squamous cell carcinoma patients

BMC Oral Health, 2023
Background HSP60 is a heat shock proteins (HSPs) family member and help mitochondrial protein to fold correctly. Survivin is one of the inhibitors of apoptosis protein family member, which plays a significant part in cancer progression. They were capable
Ying Zhou, Yaoxiang Tang, Jiadi Luo, Yang Yang, Hongjing Zang, Jian Ma, Songqing Fan, Qiuyuan Wen   +7 more
doaj   +1 more source

Humoral immune response to heat shock protein 60 of Aggregatibacter actinomycetemcomitans and cross-reactivity with malondialdehyde acetaldehyde-modified LDL.

PLoS ONE, 2020
Atherosclerosis is a chronic inflammatory disease and major cause of mortality worldwide. One of the crucial steps for atherosclerotic plaque development is oxidation of low-density lipoprotein (LDL).
Mikael Kyrklund, Mika Bildo, Ramin Akhi, Antti E Nissinen, Pirkko Pussinen, Sohvi Hörkkö, Chunguang Wang   +6 more
doaj   +1 more source

Cord blood CD4+ T cells respond to self heat shock protein 60 (HSP60). [PDF]

PLoS ONE, 2011
BACKGROUND: To prevent harmful autoimmunity most immune responses to self proteins are controlled by central and peripheral tolerance. T cells specific for a limited set of self-proteins such as human heat shock protein 60 (HSP60) may contribute to ...
Joost A Aalberse, Berber Kapitein, Sytze de Roock, Mark R Klein, Wilco de Jager, Ruurd van der Zee, Maarten O Hoekstra, Femke van Wijk, Berent J Prakken   +8 more
doaj   +1 more source

The sheep conceptus modulates proteome profiles in caruncular endometrium during early pregnancy [PDF]

, 2016
This project was funded by NHS Grampian R&D project number RG05/019Peer ...
Al-Gubory, Kaïs, Arianmanesh, Mitra, Fowler, Paul A   +2 more
core   +2 more sources

Hsp60 Inhibitors and Modulators [PDF]

Expert Opinion on Therapeutic Targets, 2019
In this chapter, we focus on the 60 KDa Heat Shock Protein (Hsp60) and discuss some of its biological, molecular and pathological features. The structural and mechanistic aspect of the Hsp60 folding cycle will be also presented. We further illustrate how Hsp60 may be involved in many diseases and therefore considered as an effective therapeutic or ...
Palumbo Piccionello, Antonio, Marzullo, Paola, Buscemi, Silvestre, Pace, Andrea   +3 more
openaire   +5 more sources

A mitochondrial unfolded protein response inhibitor suppresses prostate cancer growth in mice via HSP60

The Journal of Clinical Investigation, 2022
Mitochondrial proteostasis, regulated by the mitochondrial unfolded protein response (UPRmt), is crucial for maintenance of cellular functions and survival. Elevated oxidative and proteotoxic stress in mitochondria must be attenuated by the activation of
Rahul Kumar, Ajay K. Chaudhary, Jordan Woytash, Joseph R. Inigo, Abhiram A. Gokhale, Wiam Bshara, Kristopher Attwood, Jianmin Wang, Joseph A. Spernyak, Eva Rath, Neelu Yadav, Dirk Haller, David W. Goodrich, Dean G. Tang, Dhyan Chandra   +14 more
doaj   +1 more source

Protein translocation across mitochondrial membranes [PDF]

, 1992
Protein translocation across biological membranes is of fundamental importance for the biogenesis of organelles and in protein secretion. We will give an overview of the recent achievements in the understanding of protein translocation across ...
Arretz, Attardi, Baker, Becker, Behrens, Chen, Cheng, Chirico, Deshaies, Drygas, Dumont, Dumont, Eilers, Ellis, Hartl, Hartl, Hartl, Hawlitschek, Hines, Kang, Kellems, Kiebler, Koll, Kusakawa, Mahlke, Murakami, Murakami, Murakami, Neupert, Nicholson, Ono, Ostermann, Ostermann, Ou, Pain, Pelham, Pfaller, Pfaller, Pfanner, Pfanner, Pfanner, Pfanner, Pollock, Pon, Rassow, Rassow, Reading, Rietveld, Rothman, Scherer, Schleyer, Schneider, Schulte, Schwaiger, Steger, Stuart, Söllner, Söllner, Söllner, Vestweber, Vestweber, Wienhues, Witte   +62 more
core   +1 more source

The Hsp70 and Hsp60 Chaperone Machines

Cell, 1998
B. B. thanks members of his lab and J. Reinstein for critical reading of the manuscript and C. Gassler, T. Laufen, and S. Rudiger for figure preparation. A. H. thanks Wayne Fenton for critical reading and Zhaohui Xu for figure preparation. A. H. dedicates this work to Guenter Brueckner, always an inspiration.
Bukau, Bernd, Horwich, Arthur L
openaire   +3 more sources

Sustained inflation at birth did not alter lung injury from mechanical ventilation in surfactant-treated fetal lambs. [PDF]

, 2014
BackgroundSustained inflations (SI) are used with the initiation of ventilation at birth to rapidly recruit functional residual capacity and may decrease lung injury and the need for mechanical ventilation in preterm infants.
Hillman, Noah H, Jobe, Alan H, Kallapur, Suhas G, Kemp, Matthew W, Miura, Yuichiro   +4 more
core   +7 more sources