Results 51 to 60 of about 26,329 (222)

Hsp60 and Hsp10 as antitumour molecular agents [PDF]

Cancer Biology & Therapy, 2007
The molecular chaperones Hsp60 and Hsp10 are, according to recent reports, involved in cancer development and progression. We, for instance, have found that their expression varies with distinctive patterns in different malignancies: they are overexpressed in colorectal, exocervical and prostate carcinogenesis, and colorectal cancer progression, but ...
CAPPELLO, Francesco, CZARNECKA AM, LA ROCCA, Giampiero, DI STEFANO N, ZUMMO, Giovanni, MACARIO AJM   +5 more
openaire   +2 more sources

The Hsp60 protein of helicobacter pylori displays chaperone activity under acidic conditions

Biochemistry and Biophysics Reports, 2017
The heat shock protein, Hsp60, is one of the most abundant proteins in Helicobacter pylori. Given its sequence homology to the Escherichia coli Hsp60 or GroEL, Hsp60 from H.
Jose A. Mendoza, Kevin K. Weinberger, Matthew J. Swan   +2 more
doaj   +1 more source

Palmitic Acid Promotes Antiviral Innate Immunity via ZDHHC20‐Mediated CMPK2 Palmitoylation

Advanced Science, EarlyView.
Metabolites have important functions in innate immune activation and regulation. Wang et al. uncover metabolic regulation of antiviral immunity through CMPK2 palmitoylation, which regulates CMPK2 mitochondrial localization and is promoted by ZDHHC20 but reversed by PPT1, inhibition of which antagonizes viral infection in mice.
Yujia Wang, Zenghui Cui, Yunkai Zhang, Zhiqing Li, Xuetao Cao   +4 more
wiley   +1 more source

Humoral immune response to heat shock protein 60 of Aggregatibacter actinomycetemcomitans and cross-reactivity with malondialdehyde acetaldehyde-modified LDL.

PLoS ONE, 2020
Atherosclerosis is a chronic inflammatory disease and major cause of mortality worldwide. One of the crucial steps for atherosclerotic plaque development is oxidation of low-density lipoprotein (LDL).
Mikael Kyrklund, Mika Bildo, Ramin Akhi, Antti E Nissinen, Pirkko Pussinen, Sohvi Hörkkö, Chunguang Wang   +6 more
doaj   +1 more source

Heat Shock Protein 90: From Molecular Chaperone Function to Therapeutic Targeting in Malignancies

Advanced Science, EarlyView.
In this review, an integrated conceptual framework linking HSP90's molecular chaperone functions to its pathological roles in cancer is proposed. HSP90 serves as a central node that integrates oncogenic signaling, buffers proteotoxic stress, maintains cancer stem cell plasticity, and shapes tumor‐immune interactions, all of which converge to drive ...
Beibei Zhang, Xinxin Zou, Jiansong Zhou, Qinmiao Sun, Dahua Chen   +4 more
wiley   +1 more source

Chaperonin Hsp60 and Cancer Therapies

, 2020
The heat shock protein 60 (Hsp60) is a chaperonin belonging to the chaperoning (chaperone) system that typically contributes to protein homeostasis inside mitochondria, but also plays various non-canonical roles unrelated to protein quality control ...
Angelo Leone, Rappa, Francesca, Charbel A. Basset, Alberto J. L. Macario, Francesca Rappa, Conway de Macario, Everly, Francesco Cappello, Everly Conway de Macario, Basset, Charbel A., Cappello, Francesco, Leone, Angelo, Jurjus, Abdo R., Macario, Alberto J. L., Abdo R. Jurjus   +13 more
core   +1 more source

Immunolocalization of Hsp60 in Legionella pneumophila [PDF]

Journal of Bacteriology, 1998
ABSTRACT One of the most abundant proteins synthesized by Legionella pneumophila , particularly during growth in a variety of eukaryotic host cells, is Hsp60, a member of the GroEL family of molecular chaperones. The present study was initiated in response to a growing number of reports suggesting that for
R A, Garduño, G, Faulkner, M A, Trevors, N, Vats, P S, Hoffman   +4 more
openaire   +2 more sources

Subcellular Location of Piscirickettsia salmonis Heat Shock Protein 60 (Hsp60) Chaperone by Using Immunogold Labeling and Proteomic Analysis

Microorganisms, 2020
Piscirickettsia salmonis is the causative bacterial agent of piscirickettsiosis, a systemic fish disease that significantly impacts the Chilean salmon industry.
Cristian Oliver, Patricio Sánchez, Karla Valenzuela, Mauricio Hernández, Juan Pablo Pontigo, Maria C. Rauch, Rafael A. Garduño, Ruben Avendaño-Herrera, Alejandro J. Yáñez   +8 more
doaj   +1 more source

Chlamydia trachomatis infection and anti-Hsp60 immunity: the two sides of the coin. [PDF]

PLoS Pathogens, 2009
Chlamydia trachomatis (CT) infection is one of the most common causes of reproductive tract diseases and infertility. CT-Hsp60 is synthesized during infection and is released in the bloodstream.
Francesco Cappello, Everly Conway de Macario, Valentina Di Felice, Giovanni Zummo, Alberto J L Macario   +4 more
doaj   +1 more source

Mosaic activation of the zebrafish hsp70l heat shock promoter: Implications for interpreting transgenes

Developmental Dynamics, EarlyView.
Abstract Background The promoters and enhancers of heat shock genes, such as the 1.5‐kb promoter of the zebrafish hsp70l gene, are valuable tools for temporal activation of transgenes. It has been widely purported that heat shock treatments result in ubiquitous expression of hsp70l‐driven transgenes.
Jong‐Su Park, Xiangyun Wei
wiley   +1 more source