Results 71 to 80 of about 27,900 (188)

Chaperonotherapy for Alzheimer’s Disease: Focusing on HSP60

, 2015
This review will analyze growing evidence suggesting a convergence between two major areas of research: Alzheimer’s disease (AD) and chaperonopathies. While AD is a widely recognized medical, public health, and social problem, the chaperonopathies have ...
De Macario, Everly Conway, CAPPELLO, Francesco, Alberto J. L. Macario, Maria Grazia Ortore, MARINO GAMMAZZA, Antonella, Ortore, M., Macario, A., Francesco Cappello, PALUMBO PICCIONELLO, Antonio, Antonella Marino Gammazza, CAMPANELLA, Claudia, ORTORE, Maria Grazia, Andrea Pace, Macario, Alberto J. L., PACE, Andrea, Conway de Macario, E., Vilasi, S., Antonio Palumbo Piccionello, SAN BIAGIO, Pier Luigi, Claudia Campanella, Taglialatela, G., Pier Luigi San Biagio, Vilasi, Silvia, Everly Conway De Macario, Taglialatela, Giulio, Silvia Vilasi, Giulio Taglialatela   +26 more
core   +1 more source

HSP60: ISSUES AND INSIGHTS ON ITS THERAPEUTIC USE AS AN IMMUNOREGULATORY AGENT

Frontiers in Immunology, 2012
HSP60 is one of the most well studied member of the HSP family. Although found to be a target self antigen in pathological autoimmunity and HSP60-reactive T and B cells are part of immune responses in several infectious diseases, there is consistent ...
Veronica eCoelho, Ana Maria Caetano Faria   +1 more
doaj   +1 more source

Long non‐coding RNAs at the crossroads of inflammation, cancer and angiogenesis: Molecular mechanisms and their potential as therapeutic targets

British Journal of Pharmacology, EarlyView.
Long non‐coding RNAs (lncRNAs), a broad class of non‐protein‐coding RNAs, are characterized as new regulators of gene expression at the epigenetic, transcriptional, and post‐transcriptional level. Thus, lncRNAs are involved in the regulation of physiological processes and the development of human diseases and cancer by modulating proinflammatory ...
Charlie Leboff, Pamela Calle‐Mendoza, Maria Hatziapostolou, Christos Polytarchou   +3 more
wiley   +1 more source

Hsp60 and skeletal muscle diseases

Hsp60, a member of the chaperone system with diverse roles in health and disease, plays a crucial part in maintaining protein homeostasis inside mitochondria and has other functions outside the organelle.
Cappello, Francesco, Barone, Rosario, Macario, Alberto J. L., Conway de Macario, Everly   +3 more
core   +1 more source

Human Molecular Chaperone Hsp60 and Its Apical Domain Suppress Amyloid Fibril Formation of α-Synuclein [PDF]

Heat shock proteins play roles in assisting other proteins to fold correctly and in preventing the aggregation and accumulation of proteins in misfolded conformations.
河田, 康志, 26775, Kuroyanagi, Daichi, 26774, 26777, 溝端, 知宏, 26776, 26779, 26778, 1457, 100000563, 2225, Mizobata, Tomohiro, フクイ, ナオヤ, 26773, Adachi, Mayuka, Matsumura, Rio, 779, Hongo, Kunihiro, ミゾバタ, トモヒロ, Saiki, Eiichi, 80335504, Yamasaki, Anna, 本郷, 邦広, Kawata, Yasushi, 50263489, ホンゴ, クニヒロ, カワタ, ヤスシ, 100000572, 100000496, 26780, Fukui, Naoya, Yamamoto, Hanae, 40177697   +33 more
core   +1 more source

HSP60 critically regulates endogenous IL-1β production in activated microglia by stimulating NLRP3 inflammasome pathway

Journal of Neuroinflammation, 2018
Background Interleukin-1β (IL-1β) is one of the most important cytokine secreted by activated microglia as it orchestrates the vicious cycle of inflammation by inducing the expression of various other pro-inflammatory cytokines along with its own ...
Shalini Swaroop, Anita Mahadevan, Susarla Krishna Shankar, Yogita K. Adlakha, Anirban Basu   +4 more
doaj   +1 more source

Long‐read sequencing‐based atlas of tissue‐specific expression of DNM1L transcript variants

The FEBS Journal, EarlyView.
Targeted long‐read sequencing resolves full‐length DNM1L (Drp1) isoforms and reveals conserved, tissue‐specific expression patterns across human and mouse tissues. Functional assays show that Drp1 isoforms differ in their ability to drive mitochondrial fission, independent of abundance, with specific exons modulating activity.
Feng Yan, Jafar S. Jabbari, Naomi X. L. Ling, Anne M. Kong, Jia Q. Truong, Marnie L. Maddock, Ayeshah A. Rosdah, Christopher G. Langendorf, Lifang Zhang, Jarmon G. Lees, Sebastian Bass‐Stringer, Danise Ann Onda, Alice Pébay, Mirella Dottori, Kim Loh, Jessica K. Holien, Sean Lal, Nadia M. Davidson, Jonathan S. Oakhill, Shiang Y. Lim   +19 more
wiley   +1 more source

Hsp60 and carcinogenesis

Hsp60 emerges as a multifaceted player in cancer development, participating in various biochemical and metabolic pathways within cancer cells. Its participation in key processes such as apoptosis, cell proliferation, and immune modulation contributes to ...
Rappa F., Conway de Macario E., Cappello F., Paladino L., Macario A. J. L.   +4 more
core   +1 more source

N1-A4 recognizes HSP60 in a conformational dependent manner.

, 2022
(A) Huh7 cell lysates were immunoprecipitated with N1-A4 or goat α-HSP60, and the immunoprecipitates were detected with N1-A4 in Western blot analysis. LC, immunoglobulin light chain. (A) Huh7 cell lysates were immunoprecipitated with N1-A4 or mouse anti-
Hyun Min Lee (3609296), Min Kyu Kim (479520), Hong Seo Choi (12850975), Chun Jeih Ryu (12850978)   +3 more
core   +1 more source

Autoimmunity and Periodontitis

Journal of Periodontal Research, EarlyView.
In a microbe‐driven inflammatory environment, peptidyl‐arginine deiminase (PAD) enzymes from neutrophils and Porphyromonas gingivalis citrullinate both microbial and self‐antigens. B cell presentation of citrullinated or self‐mimicking epitopes activates T cells that assist B cells in antibody isotype switching, affinity maturation, epitope spreading ...
Massimo Costalonga, Vivek Thumbigere‐Math, Mark C. Herzberg   +2 more
wiley   +1 more source