Results 81 to 90 of about 27,900 (188)
Hsp60 in inflammation and autoimmunity
The canonical functions of the chaperone system (CS) are directed to maintaining protein homeostasis and preventing/counteracting the deleterious effects of stress.
Cappello, Francesco +4 more
core +1 more source
Periodontitis and Rheumatoid Arthritis—Mechanistic Evidence
Journal of Periodontal Research, EarlyView.Periodontitis and rheumatoid arthritis are linked via the two‐hit model whereby early periodontal inflammation can lead to autoantibody production capable of interacting with inflamed synovial tissues. Subsequent systemic inflammation can exacerbate the periodontal inflammatory response and bacterial dysbiosis leading to further autoantibody production
Mark Bartold +2 more
wiley +1 more source
The spectrum of human Hsp60 genetic variants and associated chaperonopathies
Hsp60 is one of the chief members of the chaperone system (CS) present in all organisms excepting the Archaea, with key roles in maintaining life and in resistance to the damaging effects of stressors of all types.
Cappello, Francesco +3 more
core +1 more source
Hsp60 Inhibitors and Modulators
, 2019 In this chapter, we focus on the 60 KDa Heat Shock Protein (Hsp60) and discuss some of its biological, molecular and pathological features. The structural and mechanistic aspect of the Hsp60 folding cycle will be also presented. We further illustrate how
Antonio Palumbo Piccionello +7 more
core +1 more source
Plant, Cell &Environment, EarlyView.ABSTRACT Molecular chaperones play a central role in the plant proteostasis machinery by aiding the folding of nascent proteins, preventing aggregation, and repairing or degrading damaged proteins. These functions are especially essential during abiotic and biotic stress, which can destabilise cellular proteins and disrupt metabolic homoeostasis.
Mingfang Yang +10 more
wiley +1 more source
, 2012 (A) Hsp60 levels, as measured by Hsp60 ELISA Kit (Stressgen, Ann Arbor, MI, USA), are shown for plasma samples from 20 HIV-infected patients before and after cART, and for plasma samples from 25 individuals seeking non-occupational post-exposure ...
Richard Brown (130157) +5 more
core +1 more source
Heat shock protein 60 in vascular biology [PDF]
Scripta MedicaThe response of heat shock proteins (HSPs) to stress-induced stimuli is now well documented and understood. Specific HSPs like HSP70 play an important role in vascular diseases like atherosclerosis and hypertension. However, the involvement of other HSPs
Hedley Thomas E. +3 more
doaj +1 more source
Periodontology 2000, EarlyView.Abstract Background Extracellular vesicles (EVs), especially exosomes, are nanoparticles increasingly recognized as key regulators of intercellular communication in both physiological and pathological aspects. Despite rapid progress, inconsistencies in nomenclature, isolation, and characterization continue to restrict translational advancement.
Paras Ahmad +6 more
wiley +1 more source
One day of environment‐induced heat stress causes injury to the murine kidney
Experimental Physiology, EarlyView.Abstract Environment‐induced heat stress (EIHS) results from sustained body temperature elevation owing to prolonged exposure to heat and humidity. We hypothesized that EIHS would cause kidney injury and cellular dysfunction. To test this hypothesis, female C57 mice were exposed to EIHS (n = 14; 37.6°C, 42.0% relative humidity) or thermoneutral (TN ...
Melissa Roths +3 more
wiley +1 more source
Localization of N-SMase2, Hsp60 and N-SMase2/Hsp60 complex.
, 2013 HEK-293 cells were seeded and transfected with N-SMase2 in 35-mm confocal dishes. After 24 h, (A) Cells were fixed and stained with wheat germ agglutinin (green), anti-N-SMase2 (red) and anti-HSP60 (blue) as described under ‘Materials and Methods’.
Kyong-Hoon Ahn (423974) +9 more
core +1 more source