Results 101 to 110 of about 27,900 (188)

Molecular and Proteomic Profiling of Human Cerebral Organoid‑Derived Small Extracellular Vesicles

Developmental Neurobiology, Volume 86, Issue 4, October 2026.
ABSTRACT Organoids are self‐organized, in vitro 3D structures derived from progenitor or pluripotent stem cells. During culture, these tissues secrete small extracellular vesicles (sEVs)—functional bioactive molecules—into their microenvironment. Here, we differentiated iPSC‐derived cerebral organoids (COs) under three culture conditions (static ...
Elifsu Polatlı, Burak Kahveci, Çağla Kiser, Nurhan Özlü, Gökhan Karakülah, Şermin Genç, Sinan Güven   +6 more
wiley   +1 more source

Interaction between HSP60 and beta-catenin promotes metastasis

, 2014
Heat shock protein 60 (HSP60) plays an essential role in assisting many newly synthesized proteins to reach their native forms. Increased HSP60 expression is observed in different types of human cancers with metastasis (e.g.
Huang, C.H., Tsai, Y.P., Teng, S.C., Liu, C.J., Chang, S.Y., Yang, M.H., Chen, P.M., Wu, K.J.   +7 more
core   +1 more source

Helicobacter pylori Outer Membrane Vesicles Engage TLR2 Through NapA to Promote Epithelial Association and Inflammatory Signalling

Journal of Extracellular Vesicles, Volume 15, Issue 10, October 2026.
ABSTRACT Helicobacter pylori infection is characterized by chronic gastric inflammation driven by persistent activation of innate immune signalling pathways. Outer membrane vesicles (OMVs) released by H. pylori are important mediators of host–pathogen interactions. Although several mechanisms of OMV internalization have been described, how specific OMV‐
Mariaignacia Rubilar, Rosy Brito, Annegrett Palavecino, Joan Villena, Marco Mellado, María I. Silva, Manuel Valenzuela‐Valderrama   +6 more
wiley   +1 more source

Early Dapagliflozin and Melatonin Treatment Ameliorated LV Fibrosis via Suppressing TGF‐β1/Smads and Activating Nrf2‐ARE Signaling in MI Rodent

The Kaohsiung Journal of Medical Sciences, Volume 42, Issue 10, October 2026.
ABSTRACT This study tested whether combined dapagliflozin (DAPA) and melatonin (Mel) therapy was superior to merely one for ameliorating the left ventricular (LV) fibrosis/remodeling and improving LV ejection fraction (LVEF) in rats after acute myocardial infarction (AMI). In vitro study demonstrated that DAPA treatment significantly suppressed the TGF‐
Jiunn‐Jye Sheu, Jui‐Ning Yeh, Han‐Tan Chai, John Y. Chiang, Chi‐Ruei Huang, Jun Guo, Hon‐Kan Yip   +6 more
wiley   +1 more source

Aberrant mitochondrial hsp60 expression affects mitochondria homeostasis and results in muscle dystrophy and premature death

Cell Death and Disease
Heat shock protein 60 (HSP60) plays a vital role in maintaining mitochondrial homeostasis and essential functions and requires ATP for its assembly into chaperone complexes.
Tsung-Hsien Chen, Chu-Kuang Chou, Kurt Ming-Chao Lin   +2 more
doaj   +1 more source

Mycobacterium intracellulare M.i.198—A Promising Strain for Studying Pathogenesis of Nontuberculous Mycobacterial Pulmonary Disease (NTM‐PD)

Microbiology and Immunology, Volume 70, Issue 10, Page 493-503, October 2026.
ABSTRACT In this review, we introduce a promising strain for studying pathogenesis of nontuberculous mycobacterial pulmonary disease (NTM‐PD), Mycobacterium intracellulare M.i.198. M.i.198 was isolated from a patient with progressive Mycobacterium avium‐intracellulare complex pulmonary disease (MAC‐PD) in whom surgical operation was required to ...
Yoshitaka Tateishi, Ryoji Maekura, Yukiko Nishiuchi, Sohkichi Matsumoto   +3 more
wiley   +1 more source

Does Hsp60 Provide a Link between Mitochondrial Stress and Inflammation in Diabetes Mellitus?

Journal of Diabetes Research, 2016
The focus of this review is to summarise the known relationships between the expression of heat shock protein 60 (Hsp60) and its association with the pathogenesis of Type 1 and Type 2 diabetes mellitus.
Joshua Juwono, Ryan D. Martinus
doaj   +1 more source

Microfluidic Intracytoplasmic Sperm Injection (MICSI): A Novel Platform for Sperm Isolation, Selection, and Injection Into Oocytes

Andrology, Volume 14, Issue 7, Page 2252-2261, October 2026.
ABSTRACT Background Infertility is a pressing global health concern, affecting one in six couples worldwide. The failure rate for assisted reproductive technologies (ART) cycles remains at approximately 78%, with limited improvements often attributed to a lack of technological innovation.
Mehran Dabiri, Dale Mark Goss, Steven Alexander Vasilescu, Majid Ebrahimi Warkiani   +3 more
wiley   +1 more source

Regulation und Funktionalität des Hitzeschockproteins HSP60 in Prostatakarzinomzellen [PDF]

, 2014
Tumorbiologie und molekulare Mechanismen der Progression des Prostatakarzinoms (PCa) sind komplex und bisher nur unzureichend verstanden. Trotz einiger medikamentöser Ansätze zur Therapie des PCa mit teilweise neuartigen Wirkstoffen spielen primäre und ...
Streitbörger, Andreas
core   +1 more source

Molecular characterization of the yeast gene HSP60

, 1990
In all organisms studied, heat shock or other stressful stimuli lead to profound changes in gene expression. During heat shock, a small group of evolutionarily conserved proteins, termed heat shock proteins (hsps), are synthesized in abunDance; Several ...
Reading, Donald
core   +1 more source