Results 91 to 100 of about 27,900 (188)

Elongated Flexuous Plant Virus-Derived Nanoparticles Functionalized for Autoantibody Detection

Nanomaterials, 2019
Nanoparticles derived from the elongated flexuous capsids of Turnip mosaic virus (TuMV) have been shown to be efficient tools for antibody sensing with a very high sensitivity if adequately functionalized with the corresponding epitopes. Taking advantage
Carmen Yuste-Calvo, Mercedes López-Santalla, Lucía Zurita, César F. Cruz-Fernández, Flora Sánchez, Marina I. Garín, Fernando Ponz   +6 more
doaj   +1 more source

Placental mitochondrial metabolic adaptation maintains cellular energy balance in pregnancy complicated by gestational hypoxia

The Journal of Physiology, EarlyView.
Abstract figure legend Placental mitochondrial adaptation to gestational hypoxia. Hypoxic pregnancy in sheep increases placental insulin like growth factor 2 (IGF2) signalling (1), which is associated with a shift in capacity away from β‐oxidation (2) and complex I‐mediated respiration (3), while maintaining total oxidative phosphorylation capacity (4).
Wen Tong, Beth J. Allison, Kirsty L. Brain, Olga V. Patey, Youguo Niu, Kimberley J. Botting, Sage G. Ford, Tess A. Garrud, Peter F. B. Wooding, Qiang Lyu, Lin Zhang, Jin Ma, Alice P. Sowton, Katie A. O'Brien, Tereza Cindrova‐Davies, Hong Wa Yung, Graham J. Burton, Andrew J. Murray, Dino A. Giussani   +18 more
wiley   +1 more source

SAXS profiles of GroEL and Hsp60.

, 2014
SAXS profiles of GroEL (red) and naïve Hsp60 (green). GroEL is at c = 52.5 µM, while Hsp60 is at c = 79.5 µM. Experimental curves are scaled for the sake of clarity.
Donatella Bulone (23133), Rita Carrotta (564713), Gabriella Pocsfalvi (564718), Silvia Vilasi (348324), Giovanni Zummo (314374), Annalisa Vilasi (564717), Fabio Librizzi (564714), Vincenzo Martorana (179179), Everly Conway de Macario (85293), Davide Corona (564719), Antonio Palumbo Piccionello (564720), Pier Luigi San Biagio (23136), Loredana Randazzo (564715), Francesco Cappello (55681), Giosalba Burgio (270345), Alberto J. L. Macario (314376), Maria Rosalia Mangione (179172), Claudia Campanella (314361), Antonella Marino Gammazza (451303), Maria Grazia Ortore (564716)   +19 more
core   +1 more source

The role of extracellular vesicles in cell–cell crosstalk in cardiotoxicity

The Journal of Physiology, EarlyView.
Abstract figure legend Administration of a pharmacological agent can result in off‐target cardiotoxicity which can be driven by cell–cell crosstalk between healthy and dysfunctional cardiac cells. Extracellular vesicles (EVs) are lipid bilayer structures that can move biological cargo between cells, facilitating cell–cell crosstalk.
Gabriella Bachynskyj‐Bilas, Debbie J. Otto, Daniel Stratton, Katja Rietdorf, Daniel M. Johnson, Calum J. McMullen   +5 more
wiley   +1 more source

Hsp60 Locations and Functions.

, 2013
Hsp60 Locations and Functions.
Francesco Cappello (55681), Valentina Di Felice (370801), Giovanni Zummo (314374), Alberto J. L. Macario (314376), Everly Conway de Macario (85293)   +4 more
core   +1 more source

Dichloroacetate Improves Animal Survival, Growth, Neuromuscular Activity, Mitochondrial Stress and Physiology, and Elevated Lactate in C. elegans pdha‐1 and dld‐1 RNAi Models of Pyruvate Dehydrogenase Complex Deficiency (PDCD)

Journal of Inherited Metabolic Disease, Volume 49, Issue 6, November 2026.
ABSTRACT Pyruvate dehydrogenase complex (PDHc) deficiency (PDCD) is a primary mitochondrial disorder characterized by neurodevelopmental disability, altered intermediary metabolism, and early mortality. Dichloroacetate (DCA), a pyruvate analog, activates PDHc and remains under clinical investigation for treatment of PDCD.
Cristina Remes, Neal D. Mathew, Victoria Miranda, Suraiya Haroon, Tyler O'Hara, Vernon E. Anderson, Manuela Lavorato, Kelsey Keith, Rui Xiao, Eiko Nakamaru‐Ogiso, Marni J. Falk   +10 more
wiley   +1 more source

Physical and biochemical properties of the molecular chaperone Hsp60

In cellular development, differentiation, and survival, the chaperone system (CS) takes center stage. The chief components of the CS are the molecular chaperones, some of which are called heat shock protein (Hsp).
Cappello, Francesco, D'Amico, Giuseppa, Caruso Bavisotto, Celeste, Bulone, Donatella, Vitale, Alessandra Maria, Campanella, Claudia, San Biagio, Pier Luigi, Macario, Alberto J. L., Conway de Macario, Everly   +8 more
core   +1 more source

Reactivity of Ehrlichia Hsp60 antibody.

, 2013
The Ehrlichia Hsp60 43–63 peptide was sensitive in detecting different dilutions of the Ehrlichia Hsp60 antibody. The Ehrlichia Hsp60 (250ng) was probed with different dilutions of Ehrlichia Hsp60 specific sera or sera from naïve mice.
David H. Walker (175085), Bruce A. Luxon (132655), Sunil Thomas (86994), Nagaraja R. Thirumalapura (339282), Patricia A. Crocquet-Valdes (339284)   +4 more
core   +1 more source

Mitochondrial Metabolic Reprogramming in Glioma: Mechanisms of Tumorigenesis and Implications for Clinical Therapy

CNS Neuroscience &Therapeutics, Volume 32, Issue 10, October 2026.
In gliomas, mitochondria integrate glucose, lipid, protein, and nucleotide metabolism to support proliferation, invasion, treatment resistance, and adaptation, with D‐2‐hydroxyglutarate‐driven remodeling in IDH‐mutant tumors and diverse metabolic states in IDH wild‐type glioblastomas.
Liangqi Jiang, Mingrui Li, Zhen Li, Qing Liu, Yang Li   +4 more
wiley   +1 more source

Hsp60 chaperonopathies and chaperonotherapy: targets and agents. [PDF]

, 2014
Introduction: Hsp60 (Cpn60) assembles into a tetradecamer that interacts with the co-chaperonin Hsp10 (Cpn10) to assist client polypeptides to fold, but it also has other roles, including participation in pathogenic mechanisms.
Antonio Palumbo Piccionello, Claudia Campanella, CAPPELLO, Francesco, MARINO GAMMAZZA, Antonella, Macario, AJ, Francesco Cappello, PALUMBO PICCIONELLO, Antonio, Everly Conway de Macario, Antonella Marino Gammazza, CAMPANELLA, Claudia, Andrea Pace, Alberto JL Macario, PACE, Andrea, Conway de Macario, E   +13 more
core   +1 more source