Results 91 to 100 of about 22,722 (186)

Clinicopathologic significance of heat shock protein 60 as a survival predictor in breast carcinoma

Frontiers in Oncology
BackgroundWhile Heat Shock Protein 60 (HSP60) has been linked to human tumor, its clinic significance specifically in breast carcinoma is unclear. This investigation aims to retrospectively evaluate how HSP60 protein levels relate to survival outcomes ...
Qing Wang, Shengzhou Chen, Zhihong Wu, Jungang Ni   +3 more
doaj   +1 more source

Identification and Clinical Validation of High HSP60 Expression Predicts Poor Prognosis in Patients with Ovarian Cancer

International Journal of General Medicine
Min Zheng,1,* Shaoxing Li,1,* Jie Deng,1 Chaolin Huang,1 Hua Zhang2 1Department of Gynecology and Obstetrics, Clinical Medical College and The First Affiliated Hospital of Chengdu Medical College, Chengdu, People’s Republic of China; 2Department ...
Zheng M, Li S, Deng J, Huang C, Zhang H
doaj  

Expression of the 60 and 70 kDa Family of Heat Shock Proteins in Trachea Epithelium Cells of Poults Experiencing Bordetellosis

Poultry
Heat shock protein (HSP) gene families are known to be expressed preferentially over normal cellular proteins when poultry cells are exposed to environmental stressors.
Frank W. Edens
doaj   +1 more source

HSP60 Reduction Causes an Abnormal Genotype and Sex Distribution and Impairs Mitochondrial Activity in Mouse Spermatozoa

Reproductive Medicine
Background/Objective: Fertility relies on efficient energy metabolism in gametes, which is largely determined by mitochondrial activity. The mitochondrial chaperone complex HSP60/HSP10 folds the majority of mitochondrial matrix proteins and thus enables ...
Robert Hauffe, Michaela Rath, Simran Chopra, Karin Müller, André Kleinridders   +4 more
doaj   +1 more source

Bioinformatics and Molecular Characterization Study of the HSP60 Gene of Pomacea canaliculata (Lamarck, 1822)

مجلة ديالى للعلوم الزراعية
A freshwater Pomacea canaliculata snail is widely spread across countries, including Iraq, and has the possibility for habitat alterations and lives under unusual conditions.
Sarmad Awad Mozan AL-Asadi, Noor J. A. Jouda, Sahar M. A. AL-Mothafer, Muhammed J. Al-Emara, Ali AL-Ali   +4 more
doaj   +1 more source

Pathogenic mutation impairs functional dynamics of Hsp60 in mono- and oligomeric states

Nature Communications
Mitochondrial chaperonin Heat Shock Protein 60 kDa (Hsp60) oversees the correct folding of client proteins in cooperation with Hsp10. Hsp60 monomers M first form 7-meric Single rings (S), which then pair into 14-meric Double rings (D) that accommodate ...
Luca Torielli, Federica Guarra, Hao Shao, Jason E. Gestwicki, Stefano A. Serapian, Giorgio Colombo   +5 more
doaj   +1 more source

Cellular Stress and Immune Activation in Celiac Disease: Is the Chaperone System a Key Player? [PDF]

Biology (Basel)
Vergilio G, Vultaggio G, Gagliardo R, Paladino L, Rappa F.   +4 more
europepmc   +1 more source

Heat Shock Proteins 60 and 70, Ki67 and Caspase 3 Are Differentially Expressed in the Canine Pregnant and Non-Pregnant Uterus and Ovaries. [PDF]

Vet Sci
Sabine SS, Firdevs B, Duygu K, Muhammed Ali K, Serhan A, Murat F, Selim A.   +6 more
europepmc   +1 more source

TRPM4 modulates endothelial inflammation and pyroptosis via the HSP60-NF-κB axis. [PDF]

Front Pharmacol
Shen M, Zhao Y, Zhang Y, Tong T, Cui Y, Guo X, Liang W, Ma Z, Jin J, Xiong L, Tang K, Gao K, Zhang J, Lv H, Huo R, Ban T.   +15 more
europepmc   +1 more source

HSP60 as a Drug Target

HSP60 as a Drug Target
Heat shock proteins (HSPs) are ubiquitous and evolutionary conserved proteins induced by cell stress. HSP60, in particular, is a typical mitochondrial molecular chaperone that is known to assist nascent polypeptides to reach a native conformation. HSP60 is also known to interact with HSP10.
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