Results 131 to 140 of about 352,389 (290)

Clinicopathologic Significance of Heat Shock Protein 60 as a Survival Predictor in Colorectal Cancer. [PDF]

Cancers (Basel), 2023
Kang M, Jeong S, An J, Park S, Nam S, Kwon KA, Sahoo D, Ghosh P, Kim JH.   +8 more
europepmc   +1 more source

Interplay between pleiotropy and secondary selection determines rise and fall of mutators in stress response [PDF]

, 2009
Dramatic rise of mutators has been found to accompany adaptation of bacteria in response to many kinds of stress. Two views on the evolutionary origin of this phenomenon emerged: the pleiotropic hypothesis positing that it is a byproduct of environmental
A Giraud, A Sali, AC Shaver, B Li, CS Wylie, DK Klimov, E Dekel, E Denamur, E Denamur, E Shakhnovich, E Shakhnovich, EI Shakhnovich, EI Shakhnovich, EJ Deeds, ES Slechta, Eugene I. Shakhnovich, F Taddei, G Feng, GM Suel, HC Tsui, I Bjedov, I Matic, IN Berezovsky, JAGM de Visser, JB Andre, JD Bloom, JM Raser, JW Drake, KB Zeldovich, KB Zeldovich, KB Zeldovich, KK Yan, KL Huisinga, KP Bjornson, L Lopez-Maury, M Heo, M Wrande, MB Elowitz, MJ Schofield, ML Mendillo, Muyoung Heo, N Rosenfeld, O Tenaillon, O Tenaillon, PD Sniegowski, PD Sniegowski, PJ Gerrish, PL Foster, R Du, RE Lenski, RR Iyer, RS Galhardo, RS Harris, Rustom Antia, S Maslov, S Miyazawa, WA Rosche, WJ Blake   +57 more
core   +5 more sources

Vm–MSI: a Vancomycin–Antimicrobial Peptide Conjugate Combating Resistant Bacteria and Broadening the Antimicrobial Spectrum

Advanced Science, EarlyView.
A series of vancomycin‐antimicrobial peptide conjugates is synthesized and evaluated to identify the optimal combination. Vm‐MSI, selected from multiple candidates, exhibited potent activity against vancomycin‐resistant and Gram‐negative bacteria by disrupting membranes and inducing oxidative stress, thereby expanding vancomycin's antibacterial ...
Shuangyu Li, Kang Wang, Wenzhuang Shi, Xu Wang, Duxin Li, Yanli Liu, Peng Zhang, Yipeng Wang   +7 more
wiley   +1 more source

The proteomics analysis of extracellular vesicles revealed the possible function of heat shock protein 60 in Helicobacter pylori infection. [PDF]

Cancer Cell Int, 2023
Li Y, Cao H, Qiu D, Wang N, Wang Y, Wen T, Wang J, Zhu H.   +7 more
europepmc   +1 more source

Aging cellular networks: chaperones as major participants

, 2006
We increasingly rely on the network approach to understand the complexity of cellular functions. Chaperones (heat shock proteins) are key "networkers", which have among their functions to sequester and repair damaged protein. In order to link the network
Agoston, Barabasi, Blais, Borodina, C. Sőti, Chan, Cherian, Cowen, Csermely, Csermely, Csermely, Csermely, Donaldson, Dorogovtsev, Dukan, Fares, Ferrarini, Gavin, Goldberger, Hayflick, He, Herndon, Heydari, Himmelstein, Imai, Irish, Macario, Morimoto, Mukai, Nardai, Nardai, Nollen, P. Csermely, Paulsson, Promislow, Pál, Queitsch, Rual, Rutherford, Schwarzer, Song, Stadtman, Stelzl, Sőti, Sőti, Sőti, Sőti, von Mering, Werner-Washburne, Westerheide, White, Yam, Young, Young, Zhao, Zhu, Zou   +56 more
core   +1 more source

Delta Opioid Receptors within the Cortico‐Thalamic Circuitry Underlie Hyperactivity Induced by High‐Dose Morphine

Advanced Science, EarlyView.
Morphine activates the excitatory cingulate cortex–intermediate rostrocaudal division of zona incerta (Cg‐ZIm) pathway to drive hyperlocomotion in mice. Inhibiting the Cg‐ZIm pathway attenuates both acute and chronic morphine‐induced hyperlocomotion, while its activation mimics morphine's motor effects.
Chun‐Yue Li, Huiqian Huang, Xiao‐Fan Shen, Ke‐Lei Cao, Di Zheng, Yi Zhu, Shi‐Ze Xie, Xiao‐Dan Yu, Hao Wang, Jia‐Dong Chen, Jie Shi, Yue Li, Min Yan, Xiao‐Ming Li   +13 more
wiley   +1 more source

The Roles of Heat Shock Protein-60 and 70 and Inflammation in Obesity-Related Kidney Disease. [PDF]

Cureus, 2022
Yıldırım Ö, Tatar E.
europepmc   +1 more source

Midbrain PAG Astrocytes Modulate Mouse Defensive and Panic‐Like Behaviors

Advanced Science, EarlyView.
Astrocytes in the midbrain periaqueductal gray (PAG) dynamically encode threat intensity and shape defensive action selection in mice. Real‐time Ca2+ imaging reveals robust astrocytic activation during predator odor and CO2 exposure. Aberrant astrocytic Ca2+ overactivation disrupts goal‐directed escape, biases behavior toward freezing, and induces ...
Ellane Barcelon, Kyungchul Noh, Minkyu Hwang, Yoon‐Jung Kim, Unjin Lee, Yeon Joo Ryu, Je‐Kyung Ryu, Sang Beom Jun, Se‐Young Choi, Woo‐Hyun Cho, Sung Joong Lee   +10 more
wiley   +1 more source

Strongyloides ratti : Identification, isolation and characterisation of Heat Shock Protein 10 and Heat Shock Protein 60

, 2009
S. stercoralis and S. ratti are intestinal parasitic nematodes infecting humans and rats. Both nematodes present extraordinary life cycles, comprising a free-living generation in addition to parasitic stages. To better understand the parasite?host relationship, the study of host defence?modulating molecules in parasitic systems may likely reveal new ...
Tazir, Yasmina, Justus Liebig University Giessen   +1 more
openaire   +3 more sources

Hyperandrogenemia Induces Trophoblast Ferroptosis and Early Pregnancy Loss in Patients With PCOS via CMA‐Dependent FTH1 Degradation

Advanced Science, EarlyView.
In PCOS patients with hyperandrogenemia, decreased ferritin heavy chain 1 (FTH1) causes Fe2⁺ overload and ferroptosis in trophoblasts. Androgens induce FTH1 protein degradation via AR‐LAMP2A‐mediated chaperone‐mediated autophagy pathway, leading to placental development disruption and early pregnancy loss. Metformin mitigates androgen‐induced placental
Hanjing Zhou, Weijie Yang, Na Liu, Qing Liu, Jiamin Jin, Chenqiong Zhao, Xiaoying Jin, Miao Gui, Haiyan Zhu, Songying Zhang, Yinli Zhang   +10 more
wiley   +1 more source