Results 101 to 110 of about 2,047,625 (245)

Co‐Delivery of Sustained Release Chondroitinase ABC‐37 With Human iPSC‐Derived Neural Progenitors Promotes Transplant Survival and Functional Recovery in a Rodent Model of Stroke

Advanced Science, EarlyView.
A regenerative strategy for stroke combines human stem cell–derived neural progenitor cells with sustained release of a matrix‐modifying, thermostable chondroitinase ABC‐37 enzyme. In a rat model of stroke, co‐delivery enhanced transplanted cell survival and neuronal differentiation, degraded inhibitory extracellular matrix components, and improved ...
Nitzan Letko Khait, David Xinzheyang Li, Keyi Guo, Hong Cui, Quinton Sirianni, Dhana Abdo, Cindi M. Morshead, Molly S. Shoichet   +7 more
wiley   +1 more source

Performance and analysis of a 4-stroke multi-cylinder gasoline engine with CAI combustion [PDF]

, 2002
Copyright © 2002 SAE International. This paper is posted on this site with permission from SAE International. Further use of this paper is not permitted without permission from SAEControlled Auto-Ignition (CAI) combustion was realised in a production ...
Ma, T, Ladommatos, N, Li, J, Zhao, H
core   +2 more sources

Falls after stroke: results from the Auckland Regional Community Stroke (ARCOS) study 2002-2003

, 2008
Background and Purpose— Falls are an important issue in older people. We aimed to determine the incidence, circumstances, and predictors of falls in patients with recent acute stroke.
Anderson, CS, Feigin, VL, McNaughton, HK, Parag, V, Bennett, DA, Kerse, NM, Hackett, ML   +6 more
core  

Smart Nanotechnologies for Multimodal Neuromodulation and Brain Interfacing

Advanced Science, EarlyView.
Recent advances in smart nanotechnologies are expanding the toolbox for brain interfacing, from wireless neuromodulation and high‐resolution sensing to targeted delivery within the central nervous system. By combining responsive nanomaterials with bioinspired design, these platforms enable multimodal interactions with neurons and glia, while also ...
Tommaso Curiale, Marie Celine Lefevre, Alessio Carmignani, Maria Cristina Ceccarelli, Matteo Battaglini, Attilio Marino, Gianni Ciofani   +6 more
wiley   +1 more source

Heme oxygenase 1-mediated ferroptosis in Kupffer cells initiates liver injury during heat stroke

Acta Pharmaceutica Sinica B
With the escalating prevalence of global heat waves, heat stroke has become a prominent health concern, leading to substantial liver damage. Unlike other forms of liver injury, heat stroke-induced damage is characterized by heat cytotoxicity and ...
Ru Li, Riqing Wei, Chenxin Liu, Keying Zhang, Sixiao He, Zhifeng Liu, Junhao Huang, Youyong Tang, Qiyuan An, Ligen Lin, Lishe Gan, Liying Zhao, Xiaoming Zou, Fudi Wang, Yuan Ping, Qiang Ma   +15 more
doaj   +1 more source

Molecular Editing Reveals a Bilobalide Chemotype that Attenuates Prolyl Endopeptidase (PREP)‐Linked Neuroinflammation

Advanced Science, EarlyView.
Molecular editing of bilobalide uncovers BB56, a PREP‐engaging chemotype with enhanced anti‐inflammatory activity in microglia. Integrated CETSA‐MS, SAR, and pathway analyses link BB56 to attenuation of p38 MAPK/NF‐κB and NLRP3‐associated inflammatory signaling, highlighting bilobalide editing as a strategy for developing neuroinflammation‐modulating ...
Chanin Sillapachaiyaporn, Wenjing Wang, Yao Qin, Lili Yan, Stephan Scheeff, Xu He, Qiong Wu, Yue Lin, Jinsai Shang, Xin Ye, Jing Liu, Kailei Sun, Chun Wai Yeung, Junzhe Huang, Zhenghui Chen, Xiaodong Liu, Yiqun Geng, Shannon Wing Ngor Au, Bonaventure Y. Ip, Ho Ko, Billy Wai‐Lung Ng   +20 more
wiley   +1 more source

Increased Risk of Stroke Associated with Nonsteroidal Anti-Inflammatory Drugs a Nationwide Case-Crossover Study

, 2011
Background and Purpose-Limited studies assessed cerebrovascular safety of individual nonsteroidal anti- inflammatory drugs (NSAIDs). We evaluated the risk of ischemic and hemorrhagic stroke associated with short-term use of selective and nonselective ...
張家勳;邵文逸;郭垂文;陳淑廷;賴美淑, CHANG, CHIA-HSUIN;SHAU, WEN-YI;KUO, CHUEI-WEN;CHEN, SHU-TING;LAI, MEI-SHU   +1 more
core   +1 more source

Organoid Brain‐Machine‐Interface Devices for Central Nervous System Repair

Advanced Science, EarlyView.
We envision organoid brain‐machine‐interface (Organoid‐BMI) devices as new biohybrid bidirectional communication pathways to connect the human CNS and the external world for personalized CNS repair and regeneration. ABSTRACT Central nervous system (CNS) repair and regeneration suffer from tremendous clinical challenges due to current limitations in ...
Yantao Xing, Yang Yang, Zichen Hong, Chunhui Tian, Huiyu Chu, Susanne Clara Prokop, Hongwei Cai, Mingxia Gu, Jason Tchieu, Ken Mackie, Feng Guo   +10 more
wiley   +1 more source

A Portable Soft Robotic Glove with Fully Functional Thumb Assistance for Complex Dexterous Fine Motor Skills

Advanced Science, EarlyView.
A portable, sensorized, and controlled dexterous thumb‐enhanced glove helps stroke survivors swipe phones, twist caps, and perform other tasks. It is based on a powerful continuously, segmented origami dual chamber actuator to achieve active thumb CMC and MCP joint assistance and passively extend the IP joint.
Disheng Xie, Zhen Wang, Zhongping Ye, Minghao Liu, Xiangqian Shi, Shuk Fan Tong, Jianbin Liu, Chuanbin Mao, Thomas W. Leung, Haitao Liu, Raymond Kai‐yu Tong   +10 more
wiley   +1 more source

Single-cell sequencing-based study of ferroptosis mechanisms in heat stroke: identification of key biomarkers and dynamic analysis of the immune microenvironment

BMC Medical Genomics
Background Heat stroke, caused by excessive heat production or impaired dissipation, often results from prolonged heat exposure or strenuous activity. Ferroptosis, a novel form of programmed cell death, has been implicated in its pathogenesis, though its
Defeng Yin, Qin Guo, Hao Jiang, Yonglan Hu, Lu Liu, Xiang Li, Chenglin Wang, Shilin Li, Kaiyu Jin, Yingchun Hu   +9 more
doaj   +1 more source