Results 101 to 110 of about 12,345,819 (252)
Mutant p53R273H disrupts PDPK1 homodimerization and contributes to PDPK1 activation
Molecular Oncology, EarlyView.How mutant p53R273H drives AKT signaling is unclear. We show that p53R273H, but not wild‐type, directly binds PDPK1 via a mutation‐dependent conformational change. This interaction disrupts inhibitory PDPK1 homodimerization and enhances AKT phosphorylation.
Mei Chee Lim +11 more
wiley +1 more source
Preventing failures in heat-supply systems
Problems on decreasing the number of failures in heat-supply systems are discussed. An analysis is made of existing designs of dampers and present-day equipment for damping wave processes in pipeline systems, that is, in pressure stabilizers.
Spiridonov S.V., Nizamov Kh.N.
core
Targeting the EpCAM‐AXL axis to overcome drug resistance in lung cancer
Molecular Oncology, EarlyView.Lung cancer cells often evade therapy by hijacking signaling pathways. We reveal that cleaved EpCAM (sEpCAM) stabilizes the oncogenic protein AXL, driving NF‐κB and STAT3‐mediated chemoresistance. This EpCAM‐AXL axis identifies a high‐risk patient subset with poor prognosis.
Alexa Guerrero‐Alba +5 more
wiley +1 more source
Efficiency of systems of heat supply with introduction of automated individual heating substations
, 2019 Article is devoted to increasing efficiency of heat supply systems. We demonstrate research results and an analysis of dependences of overall heat supply system performance indicators at various levels of equipment of consumers with the automated ...
A. V. Moryashev +5 more
core +1 more source
Molecular Oncology, EarlyView.This paper shows that size‐exclusion chromatography and sequential centrifugation applied to seminal plasma enrich for different populations of extracellular vesicles. This may significantly affect the detection and analysis of extracellular vesicle‐associated cancer biomarkers.
Elen Telumyan +8 more
wiley +1 more source
EnergiesIn the context of sustainable development and global challenges such as climate change and energy security, this paper conducts a bibliometric analysis of scientific journals on multi-criteria decision-making (MCDM) methods with an emphasis on their ...
Paweł Kut, Katarzyna Pietrucha-Urbanik
doaj +1 more source
Tumour‐proximal deep serum proteomics identifies biomarkers associated with ovarian cancer
Molecular Oncology, EarlyView.New biomarkers are needed for early ovarian cancer detection. Ovarian (tumour‐proximal) and peripheral vein serum from healthy women and patients with benign or malignant tumours underwent nanoparticle‐enriched deep proteomics. Ovarian serum yielded more protein identifications and revealed tumour‐reflective signatures.
Darren Lau +9 more
wiley +1 more source
Problems of energy efficiency of heat supply systems
, 2019 The main task of energy-efficient heat supply is to ensure full compliance between the produced and consumed thermal power, subject to a minimum of reduced costs. To achieve this goal, various methods of central and local regulation are applied. Analysis
Tatyana Rafalskaya
core +1 more source
Raman‐based label‐free microscopic analysis of the pancreas in living zebrafish larvae
FEBS Open Bio, EarlyView.Forward stimulated Raman scattering (F‐SRS) and epi coherent anti‐Stokes Raman scattering (E‐CARS) allow label‐free discrimination of distinct subcellular structures in the pancreas of living zebrafish larvae. Given the straightforward applicability, we anticipate broad implementation of Raman microscopy in other organs and across various biomedical ...
Noura Faraj +3 more
wiley +1 more source
Energy efficiency and energy saving in heat supply systems [PDF]
Строительство уникальных зданий и сооружений, 2013 The issue of necessity of clear reasoning behind the indicators of efficiency operation of heat supply systems is discussed in the research. The issue of finding out the main methods of improvement of efficiency operation of heat supply systems was ...
Anastasiia Dmitrievna Avsiukevich
doaj