Results 91 to 100 of about 1,960,790 (351)
Molecular Oncology, EarlyView.A mouse model for vascular normalization and a human breast cancer cohort were studied to understand the relationship between vascular leakage and tumor immune suppression. For this, endothelial and immune cell RNAseq, staining for vascular function, and immune cell profiling were employed.
Liqun He +8 more
wiley +1 more source
Energies, 2014 The circulation pump in an organic Rankine cycle (ORC) increases the pressure of the liquid working fluid from low condensing pressure to high evaporating pressure, and the expander utilizes the pressure difference to generate work.
Yu-Ting Wu +6 more
doaj +1 more source
Effect of surfactant on flow boiling heat transfer of ethylene glycol/water mixtures in a mini-tube [PDF]
, 2014 This paper was presented at the 4th Micro and Nano Flows Conference (MNF2014), which was held at University College, London, UK. The conference was organised by Brunel University and supported by the Italian Union of Thermofluiddynamics, IPEM, the ...
4th Micro and Nano Flows Conference (MNF2014) +4 more
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Molecular Oncology, EarlyView.HDAC4 is degraded by the E3 ligase FBXW7. In colorectal cancer, FBXW7 mutations prevent HDAC4 degradation, leading to oxaliplatin resistance. Forced degradation of HDAC4 using a PROTAC compound restores drug sensitivity by resetting the super‐enhancer landscape, reprogramming the epigenetic state of FBXW7‐mutated cells to resemble oxaliplatin ...
Vanessa Tolotto +13 more
wiley +1 more source
Exploiting metabolic adaptations to overcome dabrafenib treatment resistance in melanoma cells
Molecular Oncology, EarlyView.We show that dabrafenib‐resistant melanoma cells undergo mitochondrial remodeling, leading to elevated respiration and ROS production balanced by stronger antioxidant defenses. This altered redox state promotes survival despite mitochondrial damage but renders resistant cells highly vulnerable to ROS‐inducing compounds such as PEITC, highlighting redox
Silvia Eller +17 more
wiley +1 more source
Modelling linered engine blocks [PDF]
, 1991 Factors that affect heat transfer in the linered aluminium engine block are examined to determine their importance. Conduction is found to be the dominant mode of heat transfer, and the interface is characterised as imperfect contact if there are no ...
Ha, J.
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Molecular Oncology, EarlyView.The LINC01116 long noncoding RNA is induced by hypoxia and associated with poor prognosis and high recurrence rates in two cohorts of lung adenocarcinoma patients. Here, we demonstrate that besides its expression in cancer cells, LINC01116 is markedly expressed in lymphatic endothelial cells of the tumor stroma in which it participates in hypoxia ...
Marine Gautier‐Isola +12 more
wiley +1 more source
Passive heat transfer control [PDF]
, 1970 Model maintains a preselected temperature in the near vicinity of a variable source of thermal energy. Heat input is controlled by a variable transformer and a voltage drop across the heater is used to calculate power ...
Fitz, F. A.
core +1 more source
Molecular Oncology, EarlyView.Nanosecond infrared laser (NIRL) low‐volume sampling combined with shotgun lipidomics uncovers distinct lipidome alterations in oropharyngeal squamous cell carcinoma (OPSCC) of the palatine tonsil. Several lipid species consistently differentiate tumor from healthy tissue, highlighting their potential as diagnostic markers.
Leonard Kerkhoff +11 more
wiley +1 more source
, 2011 We demonstrate the possibility of achieving enhanced frequency-selective near-field radiative heat transfer between patterned (photonic crystal) slabs at designable frequencies and separations, exploiting a general numerical approach for computing heat ...
Alejandro W. Rodriguez +8 more
core +1 more source