Results 51 to 60 of about 398,956 (258)
Cell surface interactome analysis identifies TSPAN4 as a negative regulator of PD‐L1 in melanoma
Molecular Oncology, EarlyView.Using cell surface proximity biotinylation, we identified tetraspanin TSPAN4 within the PD‐L1 interactome of melanoma cells. TSPAN4 negatively regulates PD‐L1 expression and lateral mobility by limiting its interaction with CMTM6 and promoting PD‐L1 degradation.
Guus A. Franken +7 more
wiley +1 more source
Литьë и металлургия, 2006 The system of measuring of the temperature fields distributing, constructed on the basis of digital camera-recorder, is considered. It is shown that the system has advantages as compared to traditional thermal-imaging sets on receivers, operating in ...
I. V. Fain +3 more
doaj
Nanomaterials, 2020 The cooling of electronic elements is one of the most important problems in the development of architecture in electronic technology. One promising developing cooling method is heat sinks based on the phase change materials (PCMs) enhanced by nano-sized ...
Nadezhda S. Bondareva +2 more
doaj +1 more source
Molecular Oncology, EarlyView.Pharmacologic ascorbate (vitamin C) increases ROS, disrupts cellular metabolism, and induces DNA damage in CRPC cells. These effects sensitize tumors to PARP inhibition, producing synergistic growth suppression with olaparib in vitro and significantly delayed tumor progression in vivo. Pyruvate rescue confirms ROS‐dependent activity.
Nicolas Gordon +13 more
wiley +1 more source
COMPLEX INVESTIGATIONS OF THERMALPHYSIC AND INFRA-RED CHARACTERISTICS AT THE PHASE INVERSIONS
Литьë и металлургия, 2005 The complex methods of investigation of heat exchange at crystallization and melting of selectively transparent materials in terms of changing of external heat influences, which include calorimetry of IK-currents, temperature taking, the heat conduction ...
V. L. Dragun +3 more
doaj
Molecular Oncology, EarlyView.Nanosecond infrared laser (NIRL) low‐volume sampling combined with shotgun lipidomics uncovers distinct lipidome alterations in oropharyngeal squamous cell carcinoma (OPSCC) of the palatine tonsil. Several lipid species consistently differentiate tumor from healthy tissue, highlighting their potential as diagnostic markers.
Leonard Kerkhoff +11 more
wiley +1 more source
Energies, 2016 Knowledge concerning the complicated changes of mass and heat transfer is desired to improve the performance and durability of unitized regenerative fuel cells (URFCs).
Hong Xiao +3 more
doaj +1 more source
Peroxidasin enables melanoma immune escape by inhibiting natural killer cell cytotoxicity
Molecular Oncology, EarlyView.Peroxidasin (PXDN) is secreted by melanoma cells and binds the NK cell receptor NKG2D, thereby suppressing NK cell activation and cytotoxicity. PXDN depletion restores NKG2D signaling and enables effective NK cell–mediated melanoma killing. These findings identify PXDN as a previously unrecognized immune evasion factor and a potential target to improve
Hsu‐Min Sung +17 more
wiley +1 more source
Molecular Oncology, EarlyView.Methods to improve antibody–drug conjugate (ADC) treatment durability in cancer therapy are needed. We utilized ADCs and immune‐stimulating antibody conjugates (ISACs), which are made from two non‐competitive antibodies, to enhance the entry of toxic payloads into cancer cells and deliver immunostimulatory agents into immune cells.
Tiexin Wang +3 more
wiley +1 more source
Energies, 2014 The circulation pump in an organic Rankine cycle (ORC) increases the pressure of the liquid working fluid from low condensing pressure to high evaporating pressure, and the expander utilizes the pressure difference to generate work.
Yu-Ting Wu +6 more
doaj +1 more source