Results 91 to 100 of about 1,436,346 (346)

Combining antibody conjugates with cytotoxic and immune‐stimulating payloads maximizes anti‐cancer activity

Molecular Oncology, EarlyView.
Methods to improve antibody–drug conjugate (ADC) treatment durability in cancer therapy are needed. We utilized ADCs and immune‐stimulating antibody conjugates (ISACs), which are made from two non‐competitive antibodies, to enhance the entry of toxic payloads into cancer cells and deliver immunostimulatory agents into immune cells.
Tiexin Wang, Dong Jun Koo, Peter M. Tessier, Greg M. Thurber   +3 more
wiley   +1 more source

RaMBat: Accurate identification of medulloblastoma subtypes from diverse data sources with severe batch effects

Molecular Oncology, EarlyView.
To integrate multiple transcriptomics data with severe batch effects for identifying MB subtypes, we developed a novel and accurate computational method named RaMBat, which leveraged subtype‐specific gene expression ranking information instead of absolute gene expression levels to address batch effects of diverse data sources.
Mengtao Sun, Jieqiong Wang, Shibiao Wan
wiley   +1 more source

Condensation Heat Transfer Characteristics of Moist Air Outside Hydrophilic and Super-hydrophobic 3D Pin Fin Tube

Chemical Engineering Transactions, 2019
Three dimensional pin fin tube is an effective heat transfer element. It has been widely used in industry process. However, condensation heat transfer characteristic of moist air outside it has not been experimentally studied.
Yuheng Gu, Yudong Ding, Qiang Liao, Qian Fu, Xun Zhu, Hong Wang   +5 more
doaj   +1 more source

Genetic attenuation of ALDH1A1 increases metastatic potential and aggressiveness in colorectal cancer

Molecular Oncology, EarlyView.
Aldehyde dehydrogenase 1A1 (ALDH1A1) is a cancer stem cell marker in several malignancies. We established a novel epithelial cell line from rectal adenocarcinoma with unique overexpression of this enzyme. Genetic attenuation of ALDH1A1 led to increased invasive capacity and metastatic potential, the inhibition of proliferation activity, and ultimately ...
Martina Poturnajova, Zuzana Kozovska, Ondrej Pos, Kristina Pavlov, Sachin Gulati, Peter Makovicky, Kristina Jakic, Monika Burikova, Eva Sedlackova, Barbora Svitkova, Silvia Tyciakova, Vojtech Bystry, Nicolas Blavet, Boris Tichy, Matej Hrnciar, Jaroslav Budis, Miroslav Tomas, Peter Dubovan, Georgina Kolnikova, Veronika Repaska, Nikoleta Mojzesova, Eva Zomborska, Daniel Pindak, Michal Mego, Tomas Szemes, Miroslava Matuskova   +25 more
wiley   +1 more source

Experimental investigation on flow boiling heat transfer of R1233zd(E) in a variable width parallel microchannel

Zhileng xuebao
In this study, the subcooled flow boiling heat transfer of R1233zd(E) in uniform width microchannel and variable width parallel microchannel was experimentally investigated. The flow boiling curves, heat transfer coefficients and pressure drop of the two
CAI Huayu, FANG Yidong, LU Di, JIANG Chenhan   +3 more
doaj   +2 more sources

Conjugate Heat Transfer Characteristics in a Highly Thermally Loaded Film Cooling Configuration with TBC in Syngas

Aerospace, 2019
Future power equipment tends to take hydrogen or middle/low heat-value syngas as fuel for low emission. The heat transfer of a film-cooled turbine blade shall be influenced more by radiation.
Jing Ren, Xueying Li, Hongde Jiang
doaj   +1 more source

Evaluation of Evaporative Heat Transfer Characteristics of Helmets.

APPLIED HUMAN SCIENCE Journal of Physiological Anthropology, 1997
The prime purpose of a safety helmet is to protect against occupational hazards. However, thermal comfort is one important ergonomics requirement for a helmet to be accepted by its wearer. To design and manufacture a thermally comfortable helmet, a method for testing and evaluating the thermal properties is essential.
X, Liu, I, Holmér
openaire   +3 more sources

ATG4B is required for mTORC1‐mediated anabolic activity and is associated with clinical outcomes in non‐small cell lung cancer

FEBS Open Bio, EarlyView.
The relationship between anabolic and catabolic processes governing lung cancer cell growth is nuanced. We show that ATG4B, an autophagy regulator, is elevated in lung cancer and that high ATG4B is associated with worse patient outcomes. Targeting ATG4B in cells reduces growth, protein synthesis, and mTORC1 activity, demonstrating a new relationship ...
Patrick J. Ryan, Bethany C. Guerra, Selina Uranga, Jessica M. Cardin, Steven E. Riechman, Mariana Janini Gomes, James D. Fluckey   +6 more
wiley   +1 more source

The photoswitchable cannabinoid azo‐HU308 enables optical control of Ca2+ dynamics in INS‐1 β‐cells via off‐target effects on TRPC channels

FEBS Open Bio, EarlyView.
Light activation of the photoswitchable cannabinoid ligand azo‐HU308 triggers Ca2+ influx in pancreatic β‐cells through TRPC channels, independent of CB2 cannabinoid receptors. This reveals a non‐GPCR pathway for cannabinoid modulation of β‐cell Ca2+ dynamics and establishes azo‐HU308 as an optical tool to study cannabinoid signaling through TRP ...
Alexander E. G. Viray, James A. Frank
wiley   +1 more source

Flow and Convective Heat Transfer of Cylinder Misaligned from Aerodynamic Axis of Cyclone Flow

Известия высших учебных заведений и энергетических объединенний СНГ: Энергетика, 2008
The paper provides and analyzes results of experimental investigations on physical specific features of hydrodynamics and convective heat transfer of a cyclone flow with a group of round cylinders located symmetrically relative to its aerodynamic axis ...
I. L. Leukhin, E. N. Sаbourov, I. A. Usachov, V. Gаrеn   +3 more
doaj