Results 81 to 90 of about 122,906 (266)

Aquaporin‐3 and aquaporin‐5 impact the development of pancreatic ductal adenocarcinoma spheroids

FEBS Open Bio, EarlyView.
Schematic representation of the role of aquaporin‐3 (AQP3) and aquaporin‐5 (AQP5) in pancreatic ductal adenocarcinoma (PDAC). Both proteins are upregulated in PDAC and are associated with tumor progression and metastatic potential. Silencing AQP3 or AQP5 in PDAC spheroids results in decreased diameter, area, and overall growth, underscoring their key ...
Catarina Pimpão, Diogo M. Engrácia, Graça Soveral, Filipa Mendes   +3 more
wiley   +1 more source

Importin 7 mediates the nuclear import of HIV‐1 integrase via a specific interacting interface

FEBS Open Bio, EarlyView.
HIV‐1 integrase enables viral DNA integration into the host genome. By binding to the core domain of the host protein Importin 7 via its C‐terminal domain, the integrase is transported across the nuclear membrane into the nucleus, where integration of the viral genome into host DNA takes place. This translocation is a critical step for subsequent viral
Juana Bana, Avigail Yariv, Tal Oppenheim, Hadar Amartely, Dana Reichmann, Oded Livnah   +5 more
wiley   +1 more source

Dose‐dependent hepatotoxicity of hydrogen peroxide in HepG2 cells and its modulation by CYP450 induction

FEBS Open Bio, EarlyView.
NMR metabolomics revealed concentration‐dependent metabolic perturbations in HepG2 cells exposed to H2O2. Rifampicin pretreatment enhanced metabolic competence, attenuated toxin‐induced alterations and produced metabolite profiles more consistent with human liver physiology, supporting the use of CYP450‐induced HepG2 models for improved in vitro ...
Maren Jinks, Garth L. Maker, Emily C. Davies, Berin A. Boughton, Samantha Lodge   +4 more
wiley   +1 more source

Influence of insoluble aerosols on the heat-exchanging characteristics of the SPHR CV in the case of severe accidents

MATEC Web of Conferences, 2017
Analysis of the processes in severe accidents at nuclear power plants has allowed distinguishing four characteristic stages of the accident, which differ in condensation rates, concentration and composition of aerosols (table 1) [1]. The released aerosol
Nigay Aleksandr, Ivanova Natalya
doaj   +1 more source

Evolution‐guided yeast complementation reveals functional differences in human PSPH variants

FEBS Open Bio, EarlyView.
Ancient genomes can help guide which human genetic variants are tested experimentally. This study applies that idea to PSPH, a gene involved in serine biosynthesis, and uses high‐throughput yeast complementation to compare variant function. The findings reveal measurable differences among selected alleles and illustrate the value of evolution‐guided ...
Mauricio Campa‐Álvarez, Diana Ascencio, Miguel Vallebueno‐Estrada, Eduardo González‐Orozco, Christian Eduardo Martínez‐Guerrero, Rafael Montiel, Alexander DeLuna   +6 more
wiley   +1 more source

An Experimental Study on the Thermal Behavior of PCM Plaster-Lined Model House Walls During a Whole Spring Season Influenced by Their Orientation

Thermo
This study investigates how an internal PCM–gypsum plaster lining modifies orientation-dependent heat transfer through lightweight model house envelopes over a full spring season.
Mónika Ferencz, Barna Nagy, János Gyenis, Tivadar Feczkó   +3 more
doaj   +1 more source

Research on heat transfer characteristics of eccentric

Journal of Hebei University of Science and Technology, 2023
In order to explore the influence of eccentric structure on the heat transfer performance of carbon dioxide tubular the air cooler, the concentric rectangular spiral casing and eccentric rectangular spiral casing air cooler were established based on Fluent software, the temperature nephogram, velocity nephogram and specific heat capacity nephogram ...
Xinyue ZHANG, Haiting CUI, Liangrui ZHANG, Chao WANG   +3 more
openaire   +1 more source

Identifying and characterising a plant GH1 β‐glucosidase that exhibits hydrolytic activity on N‐linked glucopyranoside

FEBS Open Bio, EarlyView.
We report the first β‐glucosidase with demonstrated hydrolytic activity on an N‐linked glycopyranoside. The enzyme, native to maize, was biochemically characterised for this novel reaction, and structural modelling of the enzyme–substrate complex revealed several clues to the underlying reduced catalytic rate relative to its native O‐glycopyranoside ...
Hani Gharabli, Carlotta Chiesa, Maher Abou Hachem, Ditte Hededam Welner   +3 more
wiley   +1 more source

Experimental investigation on flow boiling heat transfer of R1233zd(E) in a variable width parallel microchannel

Zhileng xuebao
In this study, the subcooled flow boiling heat transfer of R1233zd(E) in uniform width microchannel and variable width parallel microchannel was experimentally investigated. The flow boiling curves, heat transfer coefficients and pressure drop of the two
CAI Huayu, FANG Yidong, LU Di, JIANG Chenhan   +3 more
doaj  

Simulation study on heat and mass transfer characteristics within tubular moving bed heat exchangers

Case Studies in Thermal Engineering
In the field of waste heat recovery, tubular moving bed heat exchangers (MBHEs) hold great promise as equipment capable of effectively handling large-sized granular materials with high temperature.
Weiqin Lu, Zhihan Li, Xueyu Tang, Dinghe Liu, Xiwei Ke, Tuo Zhou   +5 more
doaj   +1 more source