Results 101 to 110 of about 157,809 (262)

Neurochemical Endpoints to Inform Early‐Stage Trials of Spinocerebellar Ataxia 2 and 3 in a Multisite Setting

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Neurochemical levels measured by brain MR spectroscopy (MRS) have been proposed as endpoints for clinical trials in early‐stage spinocerebellar ataxia (SCA) trials. We tested their trial‐readiness by quantifying neurochemicals in three affected brain regions in early‐stage cohorts of SCA2 and SCA3, examining their reproducibility in ...
James M. Joers, Yaqiao Wei, Dinesh K. Deelchand, Adam Berrington, Young Woo Park, Guita Banan, Michal Povazan, Jens T. Rosenberg, André J. W. van der Kouwe, Tetsuo Ashizawa, Khalaf O. Bushara, Chiadi U. Onyike, Sub H. Subramony, Jeremy D. Schmahmann, Brian J. Soher, Peter B. Barker, Thomas H. Mareci, Eva‐Maria Ratai, Lynn E. Eberly, Gülin Öz   +19 more
wiley   +1 more source

Baseline Neuroinflammation Stratifies TSPO‐PET Response to Disease‐Modifying Therapy in Multiple Sclerosis

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective To investigate which baseline clinical and imaging characteristics best predict TSPO‐PET‐measurable reduction in glial activation following treatment of multiple sclerosis (MS), to utilize this information for designing more efficient biomarker‐based clinical trials targeting glial activation.
Marlene T. Morch, Markus Matilainen, Giulia N. Baldrighi, Marjo Nylund, Maija Saraste, Laura Airas   +5 more
wiley   +1 more source

Study on Forming Mechanism of Condensate Film of Steam-gas Mixed Fluid

Zhileng xuebao, 2013
In the condensation heat transfer process of steam-gas mixed fluid, the liquid film formed by the condensation has a great effect to heat transfer; so the discussion of the changes of the liquid film thickness along the wall was conducive to the ...
Li Huijun, Guan Xiuhong, Gao Lisha
doaj  

THE EFFECT of the USE of DIFFERENT NANOFLUIDS on the HEAT TRANSFER PERFORMANCE of a HEAT EXCHANGER

, 2022
The most important problem of heating and cooling systems is the removal of heat from the system. Heat exchangers are the most critical equipment of such systems. However, the use of nanofluids has increased significantly in recent years due to the design limitation of heat exchangers. In this study, the effect of using different nanofluids on the heat
openaire   +3 more sources

Integrated PANoptosis Profiling Identifies Immunosuppressive Subtypes and a Prognostic Signature With Functional Validation of MLKL in Glioblastoma

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective The prognosis of glioblastoma (GBM) remains highly unfavorable, largely due to high tumor heterogeneity and an immunosuppressive microenvironment. However, the functional role of PANoptosis in this context is poorly understood. Methods Patients were stratified via K‐means clustering. A risk score model was constructed using prognosis‐
Langfei Tian, Minghui Zhao, Yuanbo Hu, Kaiyue Wang, Haiguang Liu, Zetong Bai, Kebin Zheng   +6 more
wiley   +1 more source

Heat Transfer Performance of Axially Grooved Heat Pipes

Heat Transfer Performance of Axially Grooved Heat Pipes
This paper describes experiments and analysis of the heat transport capability of axially grooved heat pipes. The heat pipes were made of aluminum axially grooved extruded pipes and the working fluid was R11. The effects of fluid inventory and inclination angle on the capillary pumping limit were investigated.
openaire  

Characterization of Defect Distribution in an Additively Manufactured AlSi10Mg as a Function of Processing Parameters and Correlations with Extreme Value Statistics

Advanced Engineering Materials, EarlyView.
Predicting extreme defects in additive manufacturing remains a key challenge limiting its structural reliability. This study proposes a statistical framework that integrates Extreme Value Theory with advanced process indicators to explore defect–process relationships and improve the estimation of critical defect sizes. The approach provides a basis for
Muhammad Muteeb Butt, Varma Kvvssn, Hossein Laieghi, Zia Uddin, Peyman Ansari, E. Kıvanç Sadak, Can Barış Toprak, Hüseyin Kızıl, Enrico Salvati   +8 more
wiley   +1 more source

Study of ultrasonic influence on heat transfer and resistance performance of round tube with twisted belt

Open Physics
In this study, ultrasonic technology is combined with twisted belts to explore the comprehensive performance, and this study also investigated the effect of different Reynolds numbers, ultrasonic frequencies, and number of transducers on the performance ...
Yang Yuxi, Liu Hongyan, Yu Chulin, Wang Wenqing, Lv Xiaohan, Zhang Haiqing   +5 more
doaj   +1 more source

Evolution Law of Structural Form and Heat Transfer Performance of Thermal Insulation System. [PDF]

Materials (Basel), 2023
Zhou SX, Li JX, Bao SF, Ding Y, Wei YQ, She AM, Guo ZZ, Dong JL.   +7 more
europepmc   +1 more source

Thermomechanical Fatigue and Creep–Fatigue Interaction of Inconel 718 Additively Manufactured by Laser Beam Powder Bed Fusion

Advanced Engineering Materials, EarlyView.
Thermomechanical fatigue tests of laser beam powder bed fusion (PBF‐LB) Inconel 718 show that the additively manufactured material reaches almost the lifetimes of conventionally‐rolled material under no‐dwell conditions. Introducing dwell times at the maximum temperature markedly reduces the lifetimes due to pronounced grain boundary sliding associated
Stefan Guth, Tomáš Babinský, Jan Lars Riedel, Wen Hao Kan, Aijun Huang, Martin Heilmaier, Ivo Šulák   +6 more
wiley   +1 more source